Sökning: WFRF:(Levin Simon) > Oxygen targets and ...
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001 | oai:lup.lub.lu.se:4949a1e5-f4a6-4606-88ef-9290ff027aee | |
003 | SwePub | |
008 | 221124s2022 | |||||||||||000 ||eng| | |
009 | oai:DiVA.org:liu-189768 | |
009 | oai:prod.swepub.kib.ki.se:150994898 | |
009 | oai:gup.ub.gu.se/322298 | |
024 | 7 | a https://lup.lub.lu.se/record/4949a1e5-f4a6-4606-88ef-9290ff027aee2 URI |
024 | 7 | a https://doi.org/10.1186/s13054-022-04186-82 DOI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1897682 URI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1509948982 URI |
024 | 7 | a https://gup.ub.gu.se/publication/3222982 URI |
040 | a (SwePub)lud (SwePub)liud (SwePub)kid (SwePub)gu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Robba, Chiarau University of Genoa,San Martino Policlin Hosp, Italy; Univ Genoa, Italy4 aut |
245 | 1 0 | a Oxygen targets and 6-month outcome after out of hospital cardiac arrest : a pre-planned sub-analysis of the targeted hypothermia versus targeted normothermia after Out-of-Hospital Cardiac Arrest (TTM2) trial |
264 | c 2022-10-21 | |
264 | 1 | b Springer Science and Business Media LLC,c 2022 |
500 | a Funding Agencies|Swedish Research Council [Vetenskapsradet]; Swedish Heart-Lung Foundation; Knutsson Foundation; Stig and Ragna Gorthon Foundation; Laerdal Foundation; Hans-Gabriel and Alice Trolle-Wachtmeister Foundation for Medical Research; Regional Research Support in Region Skane); Swedish National Health Service | |
520 | a Background: Optimal oxygen targets in patients resuscitated after cardiac arrest are uncertain. The primary aim of this study was to describe the values of partial pressure of oxygen values (PaO2) and the episodes of hypoxemia and hyperoxemia occurring within the first 72 h of mechanical ventilation in out of hospital cardiac arrest (OHCA) patients. The secondary aim was to evaluate the association of PaO2 with patients’ outcome. Methods: Preplanned secondary analysis of the targeted hypothermia versus targeted normothermia after OHCA (TTM2) trial. Arterial blood gases values were collected from randomization every 4 h for the first 32 h, and then, every 8 h until day 3. Hypoxemia was defined as PaO2 < 60 mmHg and severe hyperoxemia as PaO2 > 300 mmHg. Mortality and poor neurological outcome (defined according to modified Rankin scale) were collected at 6 months. Results: 1418 patients were included in the analysis. The mean age was 64 ± 14 years, and 292 patients (20.6%) were female. 24.9% of patients had at least one episode of hypoxemia, and 7.6% of patients had at least one episode of severe hyperoxemia. Both hypoxemia and hyperoxemia were independently associated with 6-month mortality, but not with poor neurological outcome. The best cutoff point associated with 6-month mortality for hypoxemia was 69 mmHg (Risk Ratio, RR = 1.009, 95% CI 0.93–1.09), and for hyperoxemia was 195 mmHg (RR = 1.006, 95% CI 0.95–1.06). The time exposure, i.e., the area under the curve (PaO2-AUC), for hyperoxemia was significantly associated with mortality (p = 0.003). Conclusions: In OHCA patients, both hypoxemia and hyperoxemia are associated with 6-months mortality, with an effect mediated by the timing exposure to high values of oxygen. Precise titration of oxygen levels should be considered in this group of patients. Trial registration: clinicaltrials.gov NCT02908308, Registered September 20, 2016. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Anestesi och intensivvård0 (SwePub)302012 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Anesthesiology and Intensive Care0 (SwePub)302012 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng |
653 | a Cardiac arrest | |
653 | a Hyperoxemia | |
653 | a Hypoxemia | |
653 | a Mortality | |
653 | a Neurological outcome | |
653 | a Cardiac arrest; Hypoxemia; Hyperoxemia; Mortality; Neurological outcome | |
653 | a arterial oxygen | |
653 | a carbon-dioxide | |
653 | a hyperoxia | |
653 | a resuscitation | |
653 | a association | |
653 | a cardiopulmonary | |
653 | a survival | |
653 | a care | |
653 | a prognostication | |
653 | a epidemiology | |
653 | a General & Internal Medicine | |
700 | 1 | a Lilja, Giselau Lund University,Lunds universitet,Centrum för hjärtstopp,Forskargrupper vid Lunds universitet,Brain Injury After Cardiac Arrest,Center for cardiac arrest,Lund University Research Groups,Skåne University Hospital,Lund Univ, Sweden4 aut0 (Swepub:lu)med-gal |
700 | 1 | a Friberg, Hansu Lund University,Lunds universitet,Centrum för hjärtstopp,Forskargrupper vid Lunds universitet,SWECRIT,Center for cardiac arrest,Lund University Research Groups,Lund Univ, Sweden4 aut0 (Swepub:lu)efor-hfr |
700 | 1 | a Chew, Michelle S.u Linköpings universitet,Linköping University,Avdelningen för klinisk kemi och farmakologi,Medicinska fakulteten,Region Östergötland, ANOPIVA US,Skåne University Hospital4 aut0 (Swepub:lu)med-ss16 |
700 | 1 | a Unden, Johanu Lund University,Lunds universitet,Anestesiologi och intensivvård,Forskargrupper vid Lunds universitet,Anaesthesiology and Intensive Care Medicine,Lund University Research Groups,Halmstad County Hospital,Lund Univ, Sweden; Lund Univ, Sweden,Helsingborg Hospital4 aut0 (Swepub:lu)neur-jun |
700 | 1 | a Dankiewicz, Josefu Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital,Lund Univ, Sweden4 aut0 (Swepub:lu)med-jfd |
700 | 1 | a Nielsen, Niklasu Lund University,Lunds universitet,Centrum för hjärtstopp,Forskargrupper vid Lunds universitet,SEBRA Sepsis and Bacterial Resistance Alliance,Center for cardiac arrest,Lund University Research Groups,Helsingborg Hospital,Lund Univ, Sweden4 aut0 (Swepub:lu)med-nni |
700 | 1 | a Ebner, Florianu Lund University,Lunds universitet,Anestesiologi och intensivvård,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Kliniska Vetenskaper, Helsingborg,Institutionen för kliniska vetenskaper, Lund,Anesthesiology and Intensive Care,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Clinical Sciences, Helsingborg,Department of Clinical Sciences, Lund,Helsingborg Hospital,Lund Univ, Sweden4 aut0 (Swepub:lu)med-foe |
700 | 1 | a Pelosi, Paolou University of Genoa,San Martino Policlin Hosp, Italy; Univ Genoa, Italy4 aut |
700 | 1 | a Cronberg, Tobiasu Lund University,Lunds universitet,Centrum för hjärtstopp,Forskargrupper vid Lunds universitet,Brain Injury After Cardiac Arrest,Center for cardiac arrest,Lund University Research Groups4 cre0 (Swepub:lu)efor-tcr |
700 | 1 | a Erlinge, Davidu Lund University,Lunds universitet,Molekylär kardiologi,Forskargrupper vid Lunds universitet,Molecular Cardiology,Lund University Research Groups4 cre0 (Swepub:lu)kard-der |
700 | 1 | a Levin, Helenau Lund University,Lunds universitet,Centrum för hjärtstopp,Forskargrupper vid Lunds universitet,Center for cardiac arrest,Lund University Research Groups4 cre0 (Swepub:lu)ores-hal |
700 | 1 | a Nordberg, Peru Lund University,Lunds universitet,Kliniska Vetenskaper, Helsingborg,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Clinical Sciences, Helsingborg,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine4 cre0 (Swepub:lu)pe5482no |
700 | 1 | a Ullén, Susannu Lund University,Lunds universitet,Kliniska Vetenskaper, Helsingborg,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Clinical Sciences, Helsingborg,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine4 cre0 (Swepub:lu)su7040ul |
700 | 1 | a Palmér, Karolinau Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups4 cre0 (Swepub:lu)med-klc |
700 | 1 | a Karlsson, Ulla Brittu Lund University,Lunds universitet,Kliniska Vetenskaper, Helsingborg,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Clinical Sciences, Helsingborg,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine4 cre0 (Swepub:lu)med-ukn |
700 | 1 | a Heissler, Simonu Lund University,Lunds universitet,Kliniska Vetenskaper, Helsingborg,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Clinical Sciences, Helsingborg,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine4 cre0 (Swepub:lu)med-shi |
700 | 1 | a Ceric, Ameldinau Helsingborg Hospital4 cre0 (Swepub:lu)am1280bi |
700 | 1 | a Haxhija, Zanau Helsingborg Hospital4 cre0 (Swepub:lu)za1517ha |
700 | 1 | a Düring, Joachimu Skåne University Hospital4 cre0 (Swepub:lu)jo3421du |
700 | 1 | a Bergström, Mattiasu Skåne University Hospital4 cre0 (Swepub:lu)ma2685be |
700 | 1 | a Bohm, Mattiasu Skåne University Hospital4 cre0 (Swepub:lu)ma7548bo |
700 | 1 | a Didriksson, Ingridu Skåne University Hospital4 cre0 (Swepub:lu)in5403di |
700 | 1 | a Frid, Petreau Skåne University Hospital4 cre0 (Swepub:lu)med-ptf |
700 | 1 | a Heimburg, Katarinau Skåne University Hospital4 cre0 (Swepub:lu)ka7876he |
700 | 1 | a Lundberg, Oscaru Skåne University Hospital4 cre0 (Swepub:lu)os0356lu |
700 | 1 | a Hau, Stefan Olssonu Skåne University Hospital4 cre0 (Swepub:lu)med-sos |
700 | 1 | a Schmidbauer, Simonu Skåne University Hospital4 cre0 (Swepub:lu)med-ss16 |
700 | 1 | a Borgquist, Olau Skåne University Hospital4 cre0 (Swepub:lu)med-oab |
700 | 1 | a Bjärnroos, Annau Skåne University Hospital4 cre0 (Swepub:lu)an3572bj |
700 | 1 | a Blennow Nordström, Eriku Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital4 cre0 (Swepub:lu)er0251bl |
700 | 1 | a Dragancea, Irinau Skåne University Hospital4 cre0 (Swepub:lu)med-idn |
700 | 1 | a Kander, Thomasu Skåne University Hospital4 cre0 (Swepub:lu)med-tkn |
700 | 1 | a Lybeck, Annau Skåne University Hospital4 cre0 (Swepub:lu)med-aly |
700 | 1 | a Mattiasson, Gustavu Skåne University Hospital4 cre0 (Swepub:lu)efor-gma |
700 | 1 | a Rundgren, Malinu Skåne University Hospital4 cre0 (Swepub:lu)med-mrg |
700 | 1 | a Westhall, Eriku Skåne University Hospital4 cre0 (Swepub:lu)med-erw |
700 | 1 | a Annborn, Martinu Helsingborg Hospital,Lund Univ, Sweden4 cre0 (Swepub:lu)med-ma2 |
700 | 1 | a Andertun, Sarau Helsingborg Hospital4 cre0 (Swepub:lu)sa7042an |
700 | 1 | a Johnsson, Jesperu Karolinska Institutet4 cre0 (Swepub:lu)eng06jjo |
700 | 1 | a Unden, Johanu Helsingborg Hospital4 cre0 (Swepub:lu)neur-jun |
700 | 1 | a Wijdicks, Eelco F. M.4 cre |
700 | 1 | a Badenes, Rafaelu Univ Valencia, Spain; Univ Valencia, Spain4 aut |
700 | 1 | a Battaglini, Deniseu San Martino Policlin Hosp, Italy; Univ Barcelona, Spain4 aut |
700 | 1 | a Ball, Lorenzou San Martino Policlin Hosp, Italy; Univ Genoa, Italy4 aut |
700 | 1 | a Sanfilippo, Filippou AOU Policlin San Marco, Italy4 aut |
700 | 1 | a Brunetti, Ioleu San Martino Policlin Hosp, Italy4 aut |
700 | 1 | a Jakobsen, Janus Christianu Copenhagen Univ Hosp, Denmark; Univ Southern Denmark, Denmark4 aut |
700 | 1 | a Wendel-Garcia, Pedro Davidu Univ Hosp Zurich, Switzerland4 aut |
700 | 1 | a Eastwood, Glennu Monash Univ, Australia; Austin Hosp, Australia4 aut |
700 | 1 | a Thomas, Matthewu Univ Hosp Bristol NHS Fdn Trust, England4 aut |
700 | 1 | a Joannidis, Michaelu Med Univ Innsbruck, Austria4 aut |
700 | 1 | a Nichol, Alistairu Monash Univ, Australia4 aut |
700 | 1 | a Lundin, Andreasu Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för anestesiologi och intensivvård,Institute of Clinical Sciences, Department of Anesthesiology and Intensive care4 aut0 (Swepub:gu)xlandz |
700 | 1 | a Hollenberg, Jacobu Karolinska Inst, Sweden4 aut |
700 | 1 | a Hammond, Naomiu UNSW Sydney, Australia4 aut |
700 | 1 | a Saxena, Manoju St George Hosp, Australia4 aut |
700 | 1 | a Solar, Miroslavu Charles Univ Prague, Czech Republic; Univ Hosp Hradec Kralove, Czech Republic4 aut |
700 | 1 | a Taccone, Fabio Silviou Univ Libre Bruxelles, Belgium4 aut |
700 | 1 | a Grejs, Anders Mortenu Aarhus Univ Hosp, Denmark; Aarhus Univ, Denmark4 aut |
710 | 2 | a University of Genoab San Martino Policlin Hosp, Italy; Univ Genoa, Italy4 org |
710 | 2 | a TTM2 Trial collaborators |
773 | 0 | t Critical Cared : Springer Science and Business Media LLCg 26, s. 1-13q 26<1-13x 1364-8535x 1466-609X |
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856 | 4 8 | u https://lup.lub.lu.se/record/4949a1e5-f4a6-4606-88ef-9290ff027aee |
856 | 4 8 | u https://doi.org/10.1186/s13054-022-04186-8 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-189768 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:150994898 |
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