Childhood asthma and smoking exposures before conception - a three-generational cohort study.

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Fältnamn	Indikatorer	Metadata
000		04199naa a2200421 4500
001		oai:DiVA.org:umu-145533
003		SwePub
008		180309s2018 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1455332 URI
024	7	a https://doi.org/10.1111/pai.128832 DOI
040		a (SwePub)umu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Bråbäck, Lennartu Umeå universitet,Yrkes- och miljömedicin4 aut0 (Swepub:umu)lebr0005
245	1 0	a Childhood asthma and smoking exposures before conception - a three-generational cohort study.
264		c 2018-04-15
264	1	b Wiley,c 2018
338		a print2 rdacarrier
520		a BACKGROUND: Some human and animal studies have recently shown that maternal grandmother's smoking during pregnancy increases the risk of asthma in the grandchildren. We have investigated whether sex of the exposed parent and/or grandchild modifies the association between grandmaternal smoking and grandchild asthma.METHODS: We formed a cohort study based on linkage of national registries with prospectively collected data over three generations. Smoking habits in early pregnancy were registered since 1982 and purchases of prescribed medication since 2005. In all, 10329 children born since 2005 had information on maternal and grandmaternal smoking on both sides and were followed from birth up to 6 years of age. Ages when medication was purchased were used to classify the cohort into never, early transient (0-3 years), early persistent (0-3 and 4-6 years) and late-onset (4-6 years) phenotypes of childhood asthma.RESULTS: Maternal grandmother's smoking was associated with an increased odds of early persistent asthma after adjustment for maternal smoking and other confounders (odds ratio 1.29, 95% confidence interval 1.10-1.51). Grandchild sex did not modify the association. Paternal grandmother's smoking was not associated with any of the asthma phenotypes.CONCLUSION: Maternal but not paternal exposure to nicotine before conception was related to an increased risk of early persistent childhood asthma, but not other asthma phenotypes. Our findings are possibly consistent with a sex specific mode of epigenetic transfer.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Lungmedicin och allergi0 (SwePub)302192 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Respiratory Medicine and Allergy0 (SwePub)302192 hsv//eng
653		a childhood asthma
653		a grandmother
653		a multigenerational study
653		a pregnancy
653		a tobacco smoke
700	1	a Lowe, Adrian Ju Umeå universitet,Yrkes- och miljömedicin,Allergy and Lung Health Unit, Melbourne School of Population and Global Health, University of Melbourne, Australia. Murdoch Children's Research Institute, Royal Children's Hospital, Melbourne, Australia.4 aut0 (Swepub:umu)load0001
700	1	a Lodge, Caroline Ju Umeå universitet,Yrkes- och miljömedicin,Allergy and Lung Health Unit, Melbourne School of Population and Global Health, University of Melbourne, Australia. Murdoch Children's Research Institute, Royal Children's Hospital, Melbourne, Australia.4 aut0 (Swepub:umu)calo0020
700	1	a Dharmage, Shyamali Cu Allergy and Lung Health Unit, Melbourne School of Population and Global Health, University of Melbourne, Australia. Murdoch Children's Research Institute, Royal Children's Hospital, Melbourne, Australia.4 aut
700	1	a Olsson, Davidu Umeå universitet,Yrkes- och miljömedicin4 aut0 (Swepub:umu)daol0005
700	1	a Forsberg, Bertilu Umeå universitet,Yrkes- och miljömedicin4 aut0 (Swepub:umu)befo0001
710	2	a Umeå universitetb Yrkes- och miljömedicin4 org
773	0	t Pediatric Allergy and Immunologyd : Wileyg 29:4, s. 361-368q 29:4<361-368x 0905-6157x 1399-3038
856	4	u http://minerva-access.unimelb.edu.au/bitstream/11343/283698/1/https%20onlinelibrary.wiley.com%20doi%20am-pdf%2010.1111%20pai.12883.pdf
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-145533
856	4 8	u https://doi.org/10.1111/pai.12883

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Av författaren/redakt...: Bråbäck, Lennart; Lowe, Adrian J; Lodge, Caroline ...; Dharmage, Shyama ...; Olsson, David; Forsberg, Bertil

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Lungmedicin och ...

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Av lärosätet: Umeå universitet

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