Tumor Subtyping : Making Sense of Heterogeneity with a Goal Toward Treatment

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Meeks, Joshua J.Northwestern University,Jesse Brown VA Medical Center (författare)

Tumor Subtyping : Making Sense of Heterogeneity with a Goal Toward Treatment

Artikel/kapitelEngelska2021

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2021
11 s.

Nummerbeteckningar

LIBRIS-ID:oai:lup.lub.lu.se:f4868346-de57-40ce-a744-ff4df1e1342a
https://lup.lub.lu.se/record/f4868346-de57-40ce-a744-ff4df1e1342aURI
https://doi.org/10.3233/BLC-200306DOI

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Språk:engelska
Sammanfattning på:engelska

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Ämneskategori:ref swepub-contenttype

Anmärkningar

BACKGROUND: Bladder cancers have high total mutation burdens resulting in genomic diversity and intra-and inter-tumor heterogeneity that may impact the diversity of gene expression, biologic aggressiveness, and potentially response to therapy. To compare bladder cancers among patients, an organizational structure is necessary that describes the tumor at the histologic and molecular level. These 'molecular subtypes', or 'expression subtypes' of bladder cancer were originally described in 2010 and continue to evolve secondary to next generation sequencing (NGS) and an increasing public repository of well-annotated cohorts. OBJECTIVE: To review the history and methodology of expression-based subtyping of non-muscle invasive (NMIBC) and muscle invasive bladder cancer (MIBC). METHODS: A literature review was performed of primary papers from PubMed that described subtyping methods and their descriptive feature including search terms of 'subtype', and 'bladder cancer'. RESULTS: 21 papers were identified for review. Tumor subtyping developed from N = 2 to N = 6 subtyping schemes with most subtypes comprised of at least luminal and basal tumors. Most NMIBCs are luminal cancers and luminal MIBCs may be associated with less aggressive features, while one study of basal tumors identified a better clinical outcome with systemic chemotherapy. Tumors with a P53-like may have intrinsic resistance to chemotherapy. The heterogeneity of tumors, which is likely derived from stromal components and immune cell infiltration, affect subtype calls. CONCLUSION: Subtyping, while still evolving, is ready for testing in clinical trials. Improved patient selection with tumor subtyping may help with tumor classification and potentially match patient or tumor to therapy.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Cancer och onkologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Cancer and Oncology hsv//eng
Bladder cancer
expression-based subtyping
immunology
stroma
systemic therapy

Biuppslag (personer, institutioner, konferenser, titlar ...)

Sjödahl, GottfridLund University,Lunds universitet,Genomiska analyser av urinblåscancer,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Urothelial Cancer Genomics,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments(Swepub:lu)med-gsj (författare)
Lerner, Seth P.Baylor College of Medicine (författare)
Das, ArighnoUniversity of Wisconsin-Madison (författare)
McConkey, David J.Johns Hopkins University (författare)
Black, Peter C.University of British Columbia (författare)
Northwestern UniversityJesse Brown VA Medical Center (creator_code:org_t)

Sammanhörande titlar

Ingår i:Bladder Cancer7:1, s. 1-112352-3727

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Bladder Cancer (Sök värdpublikationen i LIBRIS)

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Av författaren/redakt...: Meeks, Joshua J.; Sjödahl, Gottfri ...; Lerner, Seth P.; Das, Arighno; McConkey, David ...; Black, Peter C.

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Cancer och onkol ...

Artiklar i publikationen: Bladder Cancer

Av lärosätet: Lunds universitet

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