SwePub
Sök i LIBRIS databas

  Utökad sökning

WFRF:(Nagorny Cecilia)
 

Sökning: WFRF:(Nagorny Cecilia) > Metabolomic analysi...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005143naa a2200481 4500
001oai:lup.lub.lu.se:bb2c4e80-7277-49c6-a350-94596136f527
003SwePub
008160401s2010 | |||||||||||000 ||eng|
009oai:slubar.slu.se:48454
0247 a https://lup.lub.lu.se/record/15883012 URI
0247 a https://doi.org/10.1007/s11306-009-0177-z2 DOI
0247 a https://res.slu.se/id/publ/484542 URI
040 a (SwePub)lud (SwePub)slu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Spégel, Peteru Lund University,Lunds universitet,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,Department of Experimental Medical Science,Faculty of Medicine4 aut0 (Swepub:lu)tekn-psp
2451 0a Metabolomic analysis of a human oral glucose tolerance test reveals fatty acids as reliable indicators of regulated metabolism
264 c 2009-09-01
264 1b Springer Science and Business Media LLC,c 2010
520 a Gas chromatography/mass spectrometry-based metabolomics was applied to investigate dynamic changes in the plasma metabolome upon an oral glucose tolerance test (OGTT). The OGTT is a frequently used diagnostic test of glucose homeostasis and diabetes. Diabetes is diagnosed either when glucose levels a parts per thousand yen7.0 mM in the fasting state or a parts per thousand yen11.0 mM at 2 h after oral glucose intake. The accuracy of the OGTT would, however, most likely improve if additional variables could be identified. In the present study, plasma samples were drawn every 15 min for 2 h after an oral glucose load of 75 g preceded by an overnight fast in healthy individuals. Blood plasma levels of more than 200 putative metabolites were measured. Multivariate modelling was used to distinguish metabolic regulation due to the glucose challenge from that of other variability. Two data scaling methods were applied, yielding similar results when evaluated by appropriate diagnostic tools. Fatty acid levels were found to be strongly decreased during the OGTT. Also, the levels of amino acids were shown to decrease. However, technical and uninduced biological variations were found to affect the amino acid levels to a greater extent than the fatty acid levels, making the fatty acids more reliable as indicators of metabolic regulation. Levels of several metabolites correlated with the quadratic glucose profile and two were found having an inverse correlation. Raw data plots of all identified significantly altered metabolites confirmed the excellent performance of the multivariate models. Using this approach, a better understanding of the metabolic response to an OGTT can be achieved, paving the way for inclusion of other variables describing appropriate metabolic control.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
653 a Gas chromatography
653 a tolerance test
653 a Oral glucose
653 a Metabolomics
653 a Orthogonal projections to latent structures
653 a Mass spectrometry
7001 a Danielsson, Andersu Lund University,Lunds universitet,Diabetes - klinisk obesitasforskning,Forskargrupper vid Lunds universitet,Diabetes - Clinical Obesity,Lund University Research Groups4 aut0 (Swepub:lu)tekn-ada
7001 a Bacos, Karlu Lund University,Lunds universitet,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,Department of Experimental Medical Science,Faculty of Medicine4 aut0 (Swepub:lu)medk-kb0
7001 a Nagorny, Ceciliau Lund University,Lunds universitet,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,Department of Experimental Medical Science,Faculty of Medicine4 aut0 (Swepub:lu)med-cnn
7001 a Moritz, Thomasu Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för skoglig genetik och växtfysiologi,Department of Forest Genetics and Plant Physiology4 aut0 (Swepub:slu)49634
7001 a Mulder, Hindriku Lund University,Lunds universitet,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,Department of Experimental Medical Science,Faculty of Medicine4 aut0 (Swepub:lu)medk-hmu
7001 a Filipsson, Karinu Lund University,Lunds universitet,Diabetes - molekylär metabolism,Forskargrupper vid Lunds universitet,Diabetes - Molecular Metabolism,Lund University Research Groups4 aut0 (Swepub:lu)med-kfp
7102 a Institutionen för experimentell medicinsk vetenskapb Medicinska fakulteten4 org
7102 a Sveriges lantbruksuniversitet
7730 t Metabolomicsd : Springer Science and Business Media LLCg 6:1, s. 56-66q 6:1<56-66x 1573-3882x 1573-3890
8564 u http://dx.doi.org/10.1007/s11306-009-0177-zy FULLTEXT
8564 8u https://lup.lub.lu.se/record/1588301
8564 8u https://doi.org/10.1007/s11306-009-0177-z
8564 8u https://res.slu.se/id/publ/48454

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy