WFRF:(Quiros J R)
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 09974naa a2201177 4500 | |
| 001 | oai:gup.ub.gu.se/297800 | |
| 003 | SwePub | |
| 008 | 240528s2021 | |||||||||||000 ||eng| | |
| 009 | oai:DiVA.org:umu-174900 | |
| 009 | oai:lup.lub.lu.se:09c34782-6bfd-446b-b2b5-8bde853b96df | |
| 024 | 7 | a https://gup.ub.gu.se/publication/2978002 URI |
| 024 | 7 | a https://doi.org/10.1002/ijc.332362 DOI |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1749002 URI |
| 024 | 7 | a https://lup.lub.lu.se/record/09c34782-6bfd-446b-b2b5-8bde853b96df2 URI |
| 040 | a (SwePub)gud (SwePub)umud (SwePub)lu | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Stepien, M.u International Agency for Research on Cancer, World Health Organization4 aut |
| 245 | 1 0 | a Metabolic perturbations prior to hepatocellular carcinoma diagnosis: Findings from a prospective observational cohort study |
| 264 | c 2020-08-28 | |
| 264 | 1 | b Wiley,c 2021 |
| 520 | a Hepatocellular carcinoma (HCC) development entails changes in liver metabolism. Current knowledge on metabolic perturbations in HCC is derived mostly from case-control designs, with sparse information from prospective cohorts. Our objective was to apply comprehensive metabolite profiling to detect metabolites whose serum concentrations are associated with HCC development, using biological samples from within the prospective European Prospective Investigation into Cancer and Nutrition (EPIC) cohort (>520 000 participants), where we identified 129 HCC cases matched 1:1 to controls. We conducted high-resolution untargeted liquid chromatography-mass spectrometry-based metabolomics on serum samples collected at recruitment prior to cancer diagnosis. Multivariable conditional logistic regression was applied controlling for dietary habits, alcohol consumption, smoking, body size, hepatitis infection and liver dysfunction. Corrections for multiple comparisons were applied. Of 9206 molecular features detected, 220 discriminated HCC cases from controls. Detailed feature annotation revealed 92 metabolites associated with HCC risk, of which 14 were unambiguously identified using pure reference standards. Positive HCC-risk associations were observed forN1-acetylspermidine, isatin,p-hydroxyphenyllactic acid, tyrosine, sphingosine,l,l-cyclo(leucylprolyl), glycochenodeoxycholic acid, glycocholic acid and 7-methylguanine. Inverse risk associations were observed for retinol, dehydroepiandrosterone sulfate, glycerophosphocholine, gamma-carboxyethyl hydroxychroman and creatine. Discernible differences for these metabolites were observed between cases and controls up to 10 years prior to diagnosis. Our observations highlight the diversity of metabolic perturbations involved in HCC development and replicate previous observations (metabolism of bile acids, amino acids and phospholipids) made in Asian and Scandinavian populations. These findings emphasize the role of metabolic pathways associated with steroid metabolism and immunity and specific dietary and environmental exposures in HCC development. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaper0 (SwePub)3012 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicine0 (SwePub)3012 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Gastroenterologi0 (SwePub)302132 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Gastroenterology and Hepatology0 (SwePub)302132 hsv//eng |
| 653 | a hepatocellular carcinoma | |
| 653 | a prospective observational cohort | |
| 653 | a untargeted | |
| 653 | a metabolomics | |
| 653 | a body-mass index | |
| 653 | a cancer prevention | |
| 653 | a androgen receptor | |
| 653 | a alpha-tocopherol | |
| 653 | a beta-carotene | |
| 653 | a breast-cancer | |
| 653 | a liver-disease | |
| 653 | a bile-acids | |
| 653 | a vitamin-e | |
| 653 | a serum | |
| 653 | a Oncology | |
| 653 | a hepatocellular carcinoma | |
| 653 | a untargeted metabolomics | |
| 700 | 1 | a Keski-Rahkonen, P.u International Agency for Research on Cancer, World Health Organization4 aut |
| 700 | 1 | a Kiss, A.u International Agency for Research on Cancer, World Health Organization4 aut |
| 700 | 1 | a Robinot, N.u International Agency for Research on Cancer, World Health Organization4 aut |
| 700 | 1 | a Duarte-Salles, T.u Institut Universitari d’Investigació en Atenció Primària Jordi Gol,International Agency for Research on Cancer, World Health Organization4 aut |
| 700 | 1 | a Murphy, N.u International Agency for Research on Cancer, World Health Organization4 aut |
| 700 | 1 | a Perlemuter, G.u Antoine-Béclère Hospital,Inflammation, Chimiokines et Immunopathologie (Inserm Umr 996),University of Paris-Saclay4 aut |
| 700 | 1 | a Viallon, V.u International Agency for Research on Cancer, World Health Organization4 aut |
| 700 | 1 | a Tjonneland, A.u Danish Cancer Society4 aut |
| 700 | 1 | a Rostgaard-Hansen, A. L.u Danish Cancer Society4 aut |
| 700 | 1 | a Dahm, C. C.u Aarhus University4 aut |
| 700 | 1 | a Overvad, K.u Aarhus University,Aalborg University Hospital4 aut |
| 700 | 1 | a Boutron-Ruault, M. C.u Centre for Research in Epidemiology and Population Health (CESP),Institut Gustave Roussy4 aut |
| 700 | 1 | a Mancini, F. R.u Institut Gustave Roussy,Centre for Research in Epidemiology and Population Health (CESP)4 aut |
| 700 | 1 | a Mahannat-Saleh, Y.u Centre for Research in Epidemiology and Population Health (CESP),Institut Gustave Roussy4 aut |
| 700 | 1 | a Aleksandrova, K.u German Institute of Human Nutrition4 aut |
| 700 | 1 | a Kaaks, R.u German Cancer Research Centre4 aut |
| 700 | 1 | a Kühn, Tilmanu German Cancer Research Centre4 aut0 (Swepub:lu)extLU-26 |
| 700 | 1 | a Trichopoulou, A.u National and Kapodistrian University of Athens,Hellenic Health Foundation, Athens4 aut |
| 700 | 1 | a Karakatsani, A.u Hellenic Health Foundation, Athens,National and Kapodistrian University of Athens4 aut |
| 700 | 1 | a Panico, S.u University of Naples Federico II4 aut |
| 700 | 1 | a Tumino, R.u Provincial Health Authority (ASP) Ragusa4 aut |
| 700 | 1 | a Palli, D.u Cancer Research and Prevention Institute (ISPO)4 aut |
| 700 | 1 | a Tagliabue, G.u Istituto Nazionale dei Tumori4 aut |
| 700 | 1 | a Naccarati, A.u Italian Institute for Genomic Medicine (IIGM)4 aut |
| 700 | 1 | a Vermeulen, R. C. H.u Utrecht University4 aut |
| 700 | 1 | a Bueno-de-Mesquita, H. B.u National Institute for Public Health and the Environment (RIVM),University Medical Center Utrecht,University of Malaya,Imperial College London4 aut |
| 700 | 1 | a Weiderpass, E.u International Agency for Research on Cancer, World Health Organization4 aut |
| 700 | 1 | a Skeie, G.u UiT The Arctic University of Norway, Tromsø4 aut |
| 700 | 1 | a Quiros, J. R.u Public Health Directorate4 aut |
| 700 | 1 | a Ardanaz, Evau Health Research Institute of Navarra (IDISNA),CIBER Epidemiology and Public Health (CIBERESP)4 aut0 (Swepub:lu)extLU-05 |
| 700 | 1 | a Mokoroa, O.u Biodonostia Health Research Institute,CIBER Epidemiology and Public Health (CIBERESP)4 aut |
| 700 | 1 | a Sala, N.u Catalan Institute of Oncology4 aut |
| 700 | 1 | a Sanchez, M. J.u University of Granada,CIBER Epidemiology and Public Health (CIBERESP),International Agency for Research on Cancer, World Health Organization4 aut |
| 700 | 1 | a Huerta, J. M.u CIBER Epidemiology and Public Health (CIBERESP),Murcia Regional Health Council4 aut |
| 700 | 1 | a Winkvist, Anna,d 1962u Umeå University,Umeå universitet,Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine,Avdelningen för hållbar hälsa,The Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden4 aut0 (Swepub:umu)anwi0332 |
| 700 | 1 | a Harlid, Sophia,d 1978-u Umeå University,Umeå universitet,Onkologi4 aut0 (Swepub:lu)mikr-sha |
| 700 | 1 | a Ohlsson, Bodilu Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)kir-boh |
| 700 | 1 | a Sjöberg, Klasu Lund University,Lunds universitet,Gastroenterologi,Forskargrupper vid Lunds universitet,Gastroenterology,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)medf-ksj |
| 700 | 1 | a Schmidt, J. A.u University of Oxford4 aut |
| 700 | 1 | a Wareham, N.u University of Cambridge4 aut |
| 700 | 1 | a Khaw, K. T.u University of Cambridge4 aut |
| 700 | 1 | a Ferrari, P.u International Agency for Research on Cancer, World Health Organization4 aut |
| 700 | 1 | a Rothwell, J. A.u Institut Gustave Roussy,International Agency for Research on Cancer, World Health Organization4 aut |
| 700 | 1 | a Gunter, M.u International Agency for Research on Cancer, World Health Organization4 aut |
| 700 | 1 | a Riboli, E.u Imperial College London4 aut |
| 700 | 1 | a Scalbert, A.u International Agency for Research on Cancer, World Health Organization4 aut |
| 700 | 1 | a Jenab, M.4 aut |
| 710 | 2 | a International Agency for Research on Cancer, World Health Organizationb Institut Universitari d’Investigació en Atenció Primària Jordi Gol4 org |
| 773 | 0 | t International Journal of Cancerd : Wileyg 148:3, s. 609-625q 148:3<609-625x 0020-7136x 1097-0215 |
| 856 | 4 | u http://dx.doi.org/10.1002/ijc.33236y FULLTEXT |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/297800 |
| 856 | 4 8 | u https://doi.org/10.1002/ijc.33236 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-174900 |
| 856 | 4 8 | u https://lup.lub.lu.se/record/09c34782-6bfd-446b-b2b5-8bde853b96df |
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