Effect of gastric bypass on spontaneous growth hormone and ghrelin release profiles

Mancini, M. C. (författare)

Costa, A. P. (författare)

de Melo, M. E. (författare)

Cercato, C. (författare)

Giannella-Neto, D. (författare)

Garrido, A. B., Jr. (författare)

Rosberg, Sten, 1945 (författare): Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences

Albertsson-Wikland, Kerstin, 1947 (författare): Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences

Villares, S. M. (författare)

Halpern, A. (författare)

(creator_code:org_t)

Abstract Ämnesord

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OBJECTIVE: The purpose of this study was to analyze growth hormone (GH) concentrations in obese women before and after Roux-en-Y gastric bypass (RYGBP) and how resulting changes in weight, fat mass, ghrelin levels, and insulin sensitivity affect GH secretion. RESEARCH METHODS AND PROCEDURES: Blood was sampled at 20-minute intervals for 24 hours in 10 non-diabetic premenopausal severely obese women before and 6 months after RYGBP. GH concentrations were measured in all samples, and serum ghrelin was collected at five time-points. RESULTS: After a 27% BMI drop (55.9 +/- 6.2 to 40.7 +/- 5.8 kg/m(2)), blunted GH profiles underwent partial recovery. Basal, postprandial, and mean ghrelin concentrations were not changed. A negative correlation was found between mean GH levels and insulin and homeostasis model assessment (p < 0.01). BMI accounted for 54% of GH variation. DISCUSSION: Partial recovery of GH secretion after RYGBP-induced weight loss suggests that a blunted secretion is not a causal factor of obesity but a consequence of the obese state and does not seem to be ghrelin-level dependent.

Av författaren/redakt...: Mancini, M. C.; Costa, A. P.; de Melo, M. E.; Cercato, C.; Giannella-Neto, ...; Garrido, A. B., ...; visa fler...; Rosberg, Sten, 1 ...; Albertsson-Wikla ...; Villares, S. M.; Halpern, A.; visa färre...

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