Sökning: WFRF:(Savitcheva irina) > Longitudinal uncoup...
Fältnamn | Indikatorer | Metadata |
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000 | 05459naa a2200805 4500 | |
001 | oai:DiVA.org:su-157809 | |
003 | SwePub | |
008 | 180724s2018 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:138275554 | |
009 | oai:DiVA.org:uu-337704 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-1578092 URI |
024 | 7 | a https://doi.org/10.1016/j.jalz.2017.11.0082 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1382755542 URI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3377042 URI |
040 | a (SwePub)sud (SwePub)kid (SwePub)uu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Leuzy, Antoineu Karolinska Institutet4 aut |
245 | 1 0 | a Longitudinal uncoupling of cerebral perfusion, glucose metabolism, and tau deposition in Alzheimer's disease |
264 | c 2017-12-18 | |
264 | 1 | b Wiley,c 2018 |
338 | a print2 rdacarrier | |
520 | a Introduction: Cross-sectional findings using the tau tracer [F-18] THK5317 (THK5317) have shown that [F-18]fluorodeoxyglucose (FDG) positron emission tomography (PET) data can be approximated using perfusion measures (early-frame standardized uptake value ratio; ratio of tracer delivery in target to reference regions). In this way, a single PET study can provide both functional and molecular information. Methods: We included 16 patients with Alzheimer's disease who completed follow-up THK5317 and FDG studies 17 months after baseline investigations. Linear mixed-effects models and annual percentage change maps were used to examine longitudinal change. Results: Limited spatial overlap was observed between areas showing declines in THK5317 perfusion measures and FDG. Minimal overlap was seen between areas showing functional change and those showing increased retention of THK5317. Discussion: Our findings suggest a spatiotemporal offset between functional changes and tau pathology and a partial uncoupling between perfusion and metabolism, possibly as a function of Alzheimer's disease severity. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Geriatrik0 (SwePub)302222 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Geriatrics0 (SwePub)302222 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Radiologi och bildbehandling0 (SwePub)302082 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Radiology, Nuclear Medicine and Medical Imaging0 (SwePub)302082 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Läkemedelskemi0 (SwePub)301032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medicinal Chemistry0 (SwePub)301032 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng |
653 | a Positron emission tomography (PET) | |
653 | a Tau imaging | |
653 | a THK5317 | |
653 | a Neurofibrillary tangles | |
653 | a FDG | |
653 | a Hypometabolism | |
653 | a Perfusion imaging | |
653 | a R-1 | |
653 | a Perfusion SUVR | |
653 | a Alzheimer's disease | |
653 | a Prodromal Alzheimer's disease | |
653 | a Alzheimer's disease dementia | |
653 | a Mild cognitive impairment | |
653 | a Longitudinal study | |
653 | a Psychology | |
653 | a psykologi | |
700 | 1 | a Rodriguez-Vieitez, Elenau Karolinska Institutet4 aut |
700 | 1 | a Saint-Aubert, Laure4 aut |
700 | 1 | a Chiotis, Konstantinosu Karolinska Institutet4 aut |
700 | 1 | a Almkvist, Oveu Stockholms universitet,Biologisk psykologi,Karolinska Institutet, Sweden; Karolinska University Hospital, Sweden4 aut0 (Swepub:su)almkv |
700 | 1 | a Savitcheva, Irina4 aut |
700 | 1 | a Jonasson, Myu Uppsala universitet,Radiologi,Department of Medical Physics, Uppsala University Hospital, Uppsala, Sweden4 aut0 (Swepub:uu)myajo391 |
700 | 1 | a Lubberink, Marku Uppsala universitet,Radiologi,Department of Medical Physics, Uppsala University Hospital, Uppsala, Sweden4 aut0 (Swepub:uu)marklubb |
700 | 1 | a Wall, Andersu Uppsala universitet,Radiologi,Institutionen för läkemedelskemi4 aut0 (Swepub:uu)andewall |
700 | 1 | a Antoni, Gunnaru Uppsala universitet,Institutionen för läkemedelskemi4 aut0 (Swepub:uu)gunnarat |
700 | 1 | a Nordberg, Agnetau Karolinska Institutet4 aut |
710 | 2 | a Karolinska Institutetb Biologisk psykologi4 org |
773 | 0 | t Alzheimer's & Dementiad : Wileyg 14:5, s. 652-663q 14:5<652-663x 1552-5260x 1552-5279 |
856 | 4 | u https://doi.org/10.1016/j.jalz.2017.11.008y Fulltext |
856 | 4 | u https://doi.org/10.1016/j.jalz.2017.11.008 |
856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:1170574/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-157809 |
856 | 4 8 | u https://doi.org/10.1016/j.jalz.2017.11.008 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:138275554 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-337704 |
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