WFRF:(Trollfors B.)
Sökning: WFRF:(Trollfors B.) > The diphtheria and ...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03110naa a2200469 4500 | |
| 001 | oai:gup.ub.gu.se/52822 | |
| 003 | SwePub | |
| 008 | 240528s2005 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://gup.ub.gu.se/publication/528222 URI |
| 040 | a (SwePub)gu | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Robbins, J. B.4 aut |
| 245 | 1 0 | a The diphtheria and pertussis components of diphtheria-tetanus toxoids-pertussis vaccine should be genetically inactivated mutant toxins |
| 264 | 1 | c 2005 |
| 520 | a Replacement of cellular with acellular pertussis (aP) vaccines has considerably reduced the systemic reactions observed with diphtheria-tetanus toxoids-pertussis vaccine but has not eliminated the extensive swelling (sometimes involving an entire limb) observed after the fifth injection of diphtheria-tetanus toxoids-aP (DTaP) vaccine. This local reaction, which is likely an Arthus hypersensitivity reaction caused by high levels of antibodies reacting with DTaP vaccine, could discourage its use in adults, who serve as the major reservoir of pertussis for infants. That a critical level of antibodies to pertussis toxin is both essential and sufficient to prevent infection with Bordetella pertussis is derived from data from animal and clinical studies, including data showing the similarities between the immunity induced by diphtheria and pertussis toxoids. The genetically inactivated diphtheria and pertussis mutant toxins are more immunogenic and, therefore, induce comparable levels of antitoxin at lower protein levels than do the formalin-treated native toxins. Replacement of the diphtheria and aP components with these improved antigens will reduce the amount of protein in DTaP vaccine and, most likely, the incidence and severity of local reactions in teenagers and adults. | |
| 653 | a Adult | |
| 653 | a Arthus Reaction/etiology | |
| 653 | a Child | |
| 653 | a Clinical Trials | |
| 653 | a Diphtheria/prevention & control | |
| 653 | a Diphtheria Toxin/*genetics/immunology | |
| 653 | a Diphtheria-Tetanus-acellular Pertussis Vaccines/*adverse | |
| 653 | a effects/*immunology | |
| 653 | a Humans | |
| 653 | a Infant | |
| 653 | a Mutation | |
| 653 | a Pertussis Toxin/*genetics/immunology | |
| 653 | a Tetanus/prevention & control | |
| 653 | a Vaccination | |
| 653 | a Whooping Cough/epidemiology/prevention & control | |
| 700 | 1 | a Schneerson, R.4 aut |
| 700 | 1 | a Trollfors, Birger,d 1947u Gothenburg University,Göteborgs universitet,Institutionen för kvinnors och barns hälsa, Avdelningen för pediatrik,Institute for the Health of Women and Children, Dept of Paediatrics4 aut0 (Swepub:gu)xtrobi |
| 700 | 1 | a Sato, H.4 aut |
| 700 | 1 | a Sato, Y.4 aut |
| 700 | 1 | a Rappuoli, R.4 aut |
| 700 | 1 | a Keith, J. M.4 aut |
| 710 | 2 | a Göteborgs universitetb Institutionen för kvinnors och barns hälsa, Avdelningen för pediatrik4 org |
| 773 | 0 | t J Infect Disg 191:1, s. 81-8q 191:1<81-8x 0022-1899 |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/52822 |
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