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  • Wadstrom, KarinRheumatology, Department of Clinical Sciences, Lund University, Malmö, Sweden; Center for Rheumatology, Academic Specialist Center, Region Stockholm, Stockholm, Sweden (författare)

Associations between plasma metabolism-associated proteins and future development of giant cell arteritis: results from a prospective study

  • Artikel/kapitelEngelska2024

Förlag, utgivningsår, omfång ...

  • Oxford University Press,2024

Nummerbeteckningar

  • LIBRIS-ID:oai:gup.ub.gu.se/335940
  • https://gup.ub.gu.se/publication/335940URI
  • https://doi.org/10.1093/rheumatology/keae073DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-66280URI

Kompletterande språkuppgifter

  • Språk:engelska

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Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Objective: The aim of this study was to investigate the relationship between biomarkers associated with metabolism and subsequent development of GCA. Method Participants in the population-based Malmo Diet Cancer Study (MDCS; N = 30 447) who were subsequently diagnosed with GCA were identified in a structured process. Matched: GCA-free controls were selected from the study cohort. Baseline plasma samples were analysed using the antibody-based OLINK proteomics metabolism panel (92 metabolic proteins). Analyses were pre-designated as hypothesis-driven or hypothesis-generating. In the latter, principal component analysis was used to identify groups of proteins that explained the variance in the proteome. Results: There were 95 cases with a confirmed incident diagnosis of GCA (median 12.0 years after inclusion). Among biomarkers with a priori hypotheses, adhesion G protein-coupled receptor E2 (ADGRE2) was positively associated [odds ratio (OR) per S.D. 1.67; 95% CI 1.08-2.57], and fructose-1,6-bisphosphatase 1 (FBP1) was negatively associated (OR per S.D. 0.59; 95% CI 0.35-0.99) with GCA. In particular, ADGRE2 levels were associated with subsequent GCA in the subset sampled <8.5 years before diagnosis. For meteorin-like protein (Metrnl), the highest impact on the risk of GCA was observed in those patients sampled closest to diagnosis, with a decreasing trend with longer time to GCA (P = 0.03). In the hypothesis-generating analyses, elevated levels of receptor tyrosine-like orphan receptor 1 (ROR1) were associated with subsequent GCA. Conclusion: Biomarkers identified years before clinical diagnosis indicated a protective role of gluconeogenesis (FBP1) and an association with macrophage activation (ADGRE2 and Metrnl) and proinflammatory signals (ROR1) for development of GCA.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Jacobsson, Lennart T. H.,1954Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research,Rheumatology, Department of Clinical Sciences, Lund University, Malmö, Sweden; Department of Rheumatology & Inflammation Research, Institute of Medicine, The Sahlgrenska Academy, University of Gotherburg, Gothenburg, Sweden(Swepub:gu)xjacle (författare)
  • Mohammad, Aladdin J.Department of Rheumatology, Skåne University Hospital, Malmö, Sweden; Department of Medicine, University of Cambridge, Cambridge, UK (författare)
  • Warrington, Kenneth J.Division of Rheumatology, Mayo Clinic College of Medicine and Science, Rochester, Minnesota, USA (författare)
  • Matteson, Eric L.Division of Rheumatology, Mayo Clinic College of Medicine and Science, Rochester, Minnesota, USA (författare)
  • Jakobsson, Magnus EMalmö universitet,Institutionen för biomedicinsk vetenskap (BMV),Biofilms Research Center for Biointerfaces(Swepub:mau)ao5667 (författare)
  • Turesson, CarlRheumatology, Department of Clinical Sciences, Lund University, Malmö, Sweden; Department of Rheumatology, Skåne University Hospital, Malmö, Sweden (författare)
  • Rheumatology, Department of Clinical Sciences, Lund University, Malmö, Sweden; Center for Rheumatology, Academic Specialist Center, Region Stockholm, Stockholm, SwedenInstitutionen för medicin, avdelningen för reumatologi och inflammationsforskning (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:RHEUMATOLOGY: Oxford University Press1462-03241462-0332

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