The Clinical Pharmacogenomics Implementation Consortium: CPIC Guideline for SLCO1B1 and Simvastatin-Induced Myopathy

The Clinical Pharmacogenomics Implementation Consortium : CPIC Guideline for SLCO1B1 and Simvastatin-Induced Myopathy

Cholesterol reduction from statin therapy has been one of the greatest public health successes in modern medicine. Simvastatin is among the most commonly used prescription medications. A non-synonymous coding single-nucleotide polymorphism (SNP), rs4149056, in SLCO1B1 markedly increases systemic exposure to simvastatin and the risk of muscle toxicity. This guideline explores the relationship between rs4149056 (c.521T>C, p.V174A) and clinical outcome for all statins. The strength of the evidence is high for myopathy with simvastatin. We limit our recommendations accordingly.

Ramsey, L. B. (author)
Johnson, S. G. (author)
Maxwell, W. D. (author)
McLeod, H. L. (author)
Voora, D. (author)
Krauss, R. M. (author)
Roden, D. M. (author)
Feng, Q. (author)
Cooper-DeHoff, R. M. (author)
Gong, L. (author)
Klein, T. E. (author)
Wadelius, MiaUppsala universitet,Klinisk farmakogenomik och osteoporos(Swepub:uu)miawadel (author)
Niemi, M. (author)
Uppsala universitetKlinisk farmakogenomik och osteoporos (creator_code:org_t)

In:Clinical Pharmacology and Therapeutics: Springer Science and Business Media LLC92:1, s. 112-1170009-92361532-6535

By the author/editor: Wilke, R. A.; Ramsey, L. B.; Johnson, S. G.; Maxwell, W. D.; McLeod, H. L.; Voora, D.; show more...; Krauss, R. M.; Roden, D. M.; Feng, Q.; Cooper-DeHoff, R ...; Gong, L.; Klein, T. E.; Wadelius, Mia; Niemi, M.; show less...

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