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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003655naa a2200493 4500
001oai:gup.ub.gu.se/335488
003SwePub
008240528s2023 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:153829828
0247 a https://gup.ub.gu.se/publication/3354882 URI
0247 a https://doi.org/10.3390/ijms2418143312 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1538298282 URI
040 a (SwePub)gud (SwePub)ki
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Bachar-Wikstrom, Ettyu Karolinska Institutet4 aut
2451 0a Identification of Novel Glycans in the Mucus Layer of Shark and Skate Skin
264 1c 2023
520 a The mucus layer covering the skin of fish has several roles, including protection against pathogens and mechanical damage. While the mucus layers of various bony fish species have been investigated, the composition and glycan profiles of shark skin mucus remain relatively unexplored. In this pilot study, we aimed to explore the structure and composition of shark skin mucus through histological analysis and glycan profiling. Histological examination of skin samples from Atlantic spiny dogfish (Squalus acanthias) sharks and chain catsharks (Scyliorhinus retifer) revealed distinct mucin-producing cells and a mucus layer, indicating the presence of a functional mucus layer similar to bony fish mucus albeit thinner. Glycan profiling using liquid chromatography-electrospray ionization tandem mass spectrometry unveiled a diverse repertoire of mostly O-glycans in the mucus of the two sharks as well as little skate (Leucoraja erinacea). Elasmobranch glycans differ significantly from bony fish, especially in being more sulfated, and some bear resemblance to human glycans, such as gastric mucin O-glycans and H blood group-type glycans. This study contributes to the concept of shark skin having unique properties and provides a foundation for further research into the functional roles and potential biomedical implications of shark skin mucus glycans.
650 7a NATURVETENSKAPx Biologix Biokemi och molekylärbiologi0 (SwePub)106022 hsv//swe
650 7a NATURAL SCIENCESx Biological Sciencesx Biochemistry and Molecular Biology0 (SwePub)106022 hsv//eng
653 a elasmobranchs
653 a sharks
653 a skin
653 a mucus layer
653 a mucin
653 a glycans
653 a glycoproteins
653 a O-glycans
653 a N-glycans
653 a mass spectrometry
7001 a Thomsson, Kristina A,d 1969u Gothenburg University,Göteborgs universitet,Core Facilities, Proteomics,Core Facilities, Proteomics4 aut0 (Swepub:gu)xthokr
7001 a Sihlbom, Carina,d 1973u Gothenburg University,Göteborgs universitet,Core Facilities, Proteomics,Core Facilities, Proteomics4 aut0 (Swepub:gu)xsihca
7001 a Abbo, Lisa4 aut
7001 a Tartor, Haitham4 aut
7001 a Lindén, Sara K.,d 1974u Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology4 aut0 (Swepub:gu)xlisar
7001 a Wikstrom, Jakob D.4 aut
7102 a Karolinska Institutetb Core Facilities, Proteomics4 org
7730 t INTERNATIONAL JOURNAL OF MOLECULAR SCIENCESg 24:18q 24:18x 1661-6596x 1422-0067
8564 8u https://gup.ub.gu.se/publication/335488
8564 8u https://doi.org/10.3390/ijms241814331
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:153829828

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