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Sökning: WFRF:(Amos K.) > (2015-2019) > Aspirin, NSAIDs, an...

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FältnamnIndikatorerMetadata
00004425naa a2200601 4500
001oai:DiVA.org:umu-158972
003SwePub
008190527s2019 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1589722 URI
0247 a https://doi.org/10.1158/1055-9965.EPI-18-07022 DOI
040 a (SwePub)umu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Amirian, E. Susan4 aut
2451 0a Aspirin, NSAIDs, and Glioma Risk :b Original Data from the Glioma International Case-Control Study and a Meta-analysis
264 1b American Association for Cancer Research (AACR),c 2019
338 a print2 rdacarrier
520 a Background: There have been few studies of sufficient size to address the relationship between glioma risk and the use of aspirin or NSAIDs, and results have been conflicting. The purpose of this study was to examine the associations between glioma and aspirin/NSAID use, and to aggregate these findings with prior published studies using meta-analysis.Methods: The Glioma International Case-Control Study (GICC) consists of 4,533 glioma cases and 4,171 controls recruited from 2010 to 2013. Interviews were conducted using a standardized questionnaire to obtain information on aspirin/NSAID use. We examined history of regular use for ≥6 months and duration-response. Restricted maximum likelihood meta-regression models were used to aggregate site-specific estimates, and to combine GICC estimates with previously published studies.Results: A history of daily aspirin use for ≥6 months was associated with a 38% lower glioma risk, compared with not having a history of daily use [adjusted meta-OR = 0.62; 95% confidence interval (CI), 0.54–0.70]. There was a significant duration-response trend (P = 1.67 × 10−17), with lower ORs for increasing duration of aspirin use. Duration-response trends were not observed for NSAID use. In the meta-analysis aggregating GICC data with five previous studies, there was a marginally significant association between use of aspirin and glioma (mOR = 0.84; 95% CI, 0.70–1.02), but no association for NSAID use.Conclusions: Our study suggests that aspirin may be associated with a reduced risk of glioma.Impact: These results imply that aspirin use may be associated with decreased glioma risk. Further research examining the association between aspirin use and glioma risk is warranted.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Arbetsmedicin och miljömedicin0 (SwePub)303032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Occupational Health and Environmental Health0 (SwePub)303032 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi0 (SwePub)303022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Public Health, Global Health, Social Medicine and Epidemiology0 (SwePub)303022 hsv//eng
7001 a Ostrom, Quinn T.4 aut
7001 a Armstrong, Georgina N.4 aut
7001 a Lai, Rose K.4 aut
7001 a Gu, Xiangjun4 aut
7001 a Jacobs, Daniel I.4 aut
7001 a Jalali, Ali4 aut
7001 a Claus, Elizabeth B.4 aut
7001 a Barnholtz-Sloan, Jill S.4 aut
7001 a Il'yasova, Dora4 aut
7001 a Schildkraut, Joellen M.4 aut
7001 a Ali-Osman, Francis4 aut
7001 a Sadetzki, Siegal4 aut
7001 a Jenkins, Robert B.4 aut
7001 a Lachance, Daniel H.4 aut
7001 a Olson, Sara H.4 aut
7001 a Bernstein, Jonine L.4 aut
7001 a Merrell, Ryan T.4 aut
7001 a Wrensch, Margaret R.4 aut
7001 a Johansen, Christoffer4 aut
7001 a Houlston, Richard S.4 aut
7001 a Scheurer, Michael E.4 aut
7001 a Shete, Sanjay4 aut
7001 a Amos, Christopher I.4 aut
7001 a Melin, Beatrice S.u Umeå universitet,Onkologi4 aut0 (Swepub:umu)bema0010
7001 a Bondy, Melissa L.4 aut
7102 a Umeå universitetb Onkologi4 org
7730 t Cancer Epidemiology, Biomarkers and Preventiond : American Association for Cancer Research (AACR)g 28:3, s. 555-562q 28:3<555-562x 1055-9965x 1538-7755
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-158972
8564 8u https://doi.org/10.1158/1055-9965.EPI-18-0702

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