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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00006741naa a2200889 4500
001oai:DiVA.org:uu-76843
003SwePub
008070308s2005 | |||||||||||000 ||eng|
009oai:DiVA.org:umu-13360
009oai:lup.lub.lu.se:a9b43f55-e5e9-46b0-95d9-2eb7d231fc22
009oai:prod.swepub.kib.ki.se:111440049
009oai:DiVA.org:liu-33260
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-768432 URI
0247 a https://doi.org/10.1136/ard.2004.0332412 DOI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-133602 URI
0247 a https://lup.lub.lu.se/record/2246632 URI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1114400492 URI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-332602 URI
040 a (SwePub)uud (SwePub)umud (SwePub)lud (SwePub)kid (SwePub)liu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Askling, Ju Karolinska Institutet4 aut
2451 0a Haematopoietic malignancies in rheumatoid arthritis :b lymphoma risk and characteristics after exposure to tumour necrosis factor antagonists
264 1b BMJ,c 2005
338 a print2 rdacarrier
520 a BACKGROUND:Patients with rheumatoid arthritis (RA) are at increased risk of malignant lymphomas, and maybe also of leukaemia and multiple myeloma. The effect of tumour necrosis factor (TNF) antagonists on lymphoma risk and characteristics is unclear.OBJECTIVE:To assess expected rates and relative risks of haematopoietic malignancies, especially those associated with TNF antagonists, in large population based cohorts of patients with RA.METHODS:A population based cohort study was performed of patients with RA (one prevalent cohort (n = 53,067), one incident cohort (n = 3703), and one TNF antagonist treated cohort 1999 through 2003 (n = 4160)), who were linked with the Swedish Cancer Register. Additionally, the lymphoma specimens for the 12 lymphomas occurring in patients with RA exposed to TNF antagonists in Sweden 1999 through 2004 were reviewed.RESULTS:Study of almost 500 observed haematopoietic malignancies showed that prevalent and incident patients with RA were at increased risk of lymphoma (SIR = 1.9 and 2.0, respectively) and leukaemia (SIR = 2.1 and 2.2, respectively) but not of myeloma. Patients with RA treated with TNF antagonists had a tripled lymphoma risk (SIR = 2.9) compared with the general population. After adjustment for sex, age, and disease duration, the lymphoma risk after exposure to TNF antagonists was no higher than in the other RA cohorts. Lymphomas associated with TNF antagonists had characteristics similar to those of other RA lymphomas.CONCLUSION:Overall, patients with RA are at equally increased risks for lymphomas and leukaemias. Patients with RA treated with TNF antagonists did not have higher lymphoma risks than other patients with RA. Prolonged observation is needed to determine the long term effects of TNF antagonists on lymphoma risk.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reumatologi och inflammation0 (SwePub)302102 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Rheumatology and Autoimmunity0 (SwePub)302102 hsv//eng
653 a Adolescent
653 a Adult
653 a Aged
653 a Antirheumatic Agents/*adverse effects/therapeutic use
653 a Arthritis; Rheumatoid/*drug therapy/epidemiology
653 a Biological Response Modifiers/*adverse effects/therapeutic use
653 a Epidemiologic Methods
653 a Female
653 a Hematologic Neoplasms/*chemically induced/epidemiology
653 a Humans
653 a Leukemia/chemically induced/epidemiology
653 a Lymphoma/chemically induced/epidemiology
653 a Male
653 a Middle Aged
653 a Research Support; Non-U.S. Gov't
653 a Sweden/epidemiology
653 a Tumor Necrosis Factor-alpha/*antagonists & inhibitors
653 a MEDICINE
7001 a Fored, C Mu Karolinska Institutet4 aut
7001 a Baecklund, Evau Uppsala universitet,Reumatologi4 aut0 (Swepub:uu)evaba786
7001 a Brandt, Lu Karolinska Institutet4 aut
7001 a Backlin, Carinu Uppsala universitet,Institutionen för genetik och patologi4 aut0 (Swepub:uu)kariback
7001 a Ekbom, Au Karolinska Institutet4 aut
7001 a Sundström, Christeru Uppsala universitet,Molekylär och morfologisk patologi4 aut0 (Swepub:uu)chrisund
7001 a Bertilsson, L4 aut
7001 a Cöster, Lars,d 1945-u Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Reumatologi,Länskliniken för Reumatologi i Östergötland4 aut0 (Swepub:liu)larco79
7001 a Geborek, Pierreu Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)reum-pge
7001 a Jacobsson, L T4 aut
7001 a Lindblad, Su Karolinska Institutet4 aut
7001 a Lysholm, J4 aut
7001 a Rantapää-Dahlqvist, Solbrittu Umeå universitet,Reumatologi4 aut0 (Swepub:umu)sora0001
7001 a Saxne, Toreu Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)reum-tsa
7001 a Klareskog, Lu Karolinska Institutet4 aut
7001 a Feltelius, Nu Uppsala universitet,Reumatologi4 aut
7102 a Karolinska Institutetb Reumatologi4 org
7730 t Annals of the Rheumatic Diseasesd : BMJg 64:10, s. 1414-1420q 64:10<1414-1420x 0003-4967x 1468-2060
8564 u https://ard.bmj.com/content/64/10/1414.full.pdf
8564 u http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=15843454&dopt=Citation
8564 u http://dx.doi.org/10.1136/ard.2004.033241x freey FULLTEXT
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-76843
8564 8u https://doi.org/10.1136/ard.2004.033241
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-13360
8564 8u https://lup.lub.lu.se/record/224663
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:111440049
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-33260

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