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Accelerometer-measu...
Accelerometer-measured sedentary behavior patterns, brain structure, and cognitive function in dementia-free older adults : a population-based study
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- Han, Xiaolei (författare)
- Department of Neurology, Shandong Provincial Hospital, Shandong First Medical University, Jinan, Shandong, China; Department of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China
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- Song, Lin (författare)
- Department of Neurology, Shandong Provincial Hospital, Shandong First Medical University, Jinan, Shandong, China; Department of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China
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- Li, Yuanjing (författare)
- Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI)
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- Dong, Yi (författare)
- Department of Neurology, Shandong Provincial Hospital, Shandong First Medical University, Jinan, Shandong, China; Department of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China
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- Liu, Rui (författare)
- Department of Neurology, Shandong Provincial Hospital, Shandong First Medical University, Jinan, Shandong, China; Department of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China
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- Han, Qi (författare)
- Department of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China
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- Wang, Xiaojie (författare)
- Department of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China
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- Mao, Ming (författare)
- Department of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China
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- Cong, Lin (författare)
- Department of Neurology, Shandong Provincial Hospital, Shandong First Medical University, Jinan, Shandong, China; Department of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China
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- Tang, Shi (författare)
- Department of Neurology, Shandong Provincial Hospital, Shandong First Medical University, Jinan, Shandong, China; Department of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China
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- Hou, Tingting (författare)
- Department of Neurology, Shandong Provincial Hospital, Shandong First Medical University, Jinan, Shandong, China; Department of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China
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- Zhang, Qinghua (författare)
- Department of Neurology, Shandong Provincial Hospital, Shandong First Medical University, Jinan, Shandong, China; Department of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China
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- Liu, Cuicui (författare)
- Karolinska Institutet
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- Han, Xiaodong (författare)
- Department of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China
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- Shi, Lin (författare)
- BrainNow Research Institute, Shenzhen, Guangdong, China; Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Hong Kong, Hong Kong
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- Nyberg, Lars, 1966- (författare)
- Umeå universitet,Diagnostisk radiologi
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- Launer, Lenore J. (författare)
- Intramural Research Program, Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, MD, Baltimore, United States
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- Wang, Yongxiang (författare)
- Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Shandong First Medical University, China; Shandong Academy of Medical Sciences, China
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- Du, Yifeng (författare)
- Department of Neurology, Shandong Provincial Hospital, Shandong First Medical University, Jinan, Shandong, China; Department of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China
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- Qiu, Chengxuan (författare)
- Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Shandong First Medical University, China; Shandong Academy of Medical Sciences, China
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(creator_code:org_t)
- IOS Press, 2023
- 2023
- Engelska.
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Ingår i: Journal of Alzheimer's Disease. - : IOS Press. - 1387-2877 .- 1875-8908. ; 96:2, s. 657-668
- Relaterad länk:
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https://doi.org/10.3...
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https://umu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.3...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
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- Background: Sedentary behavior is associated with cognitive impairment, but the neuropathological mechanisms underlying their associations are poorly understood.Objective: To investigate the associations of accelerometer-measured sedentary behavior patterns with brain structure and cognition, and further to explore the potential mechanisms.Methods: This community-based study included 2,019 older adults (age≥60 years, 59% women) without dementia derived from participants in the baseline examination of MIND-China (2018-2020). We assessed sedentary parameters using an accelerometer and cognitive function using a neuropsychological test battery. Structural brain markers were assessed on the structural brain MRI scans in a subsample (n = 1,009). Data were analyzed using the general linear, isotemporal substitution, and mediation models.Results: In the total sample (n = 2,019), adjusting for multiple covariates and moderate-to-vigorous-intensity physical activity, longer mean sedentary bout duration was linearly related with lower z-scores of global cognition, verbal fluency, and memory (ptrend < 0.05), whereas greater total sedentary time was linearly associated with lower z-scores of global cognition, verbal fluency, and memory only among individuals with long sedentary time (>10 h/day) (ptrend < 0.05); Breaking up sedentary time with same amount of light-intensity physical activity was significantly associated with higher verbal fluency and memory z-scores (p < 0.05). In the MRI subsample (n = 1,009), separately entering structural brain MRI markers into the mediation models substantially attenuated the associations of mean sedentary bout duration with global cognition, verbal fluency, and memory z-scores.Conclusion: Prolonged uninterrupted sedentary time is associated with poor global cognition, memory, and verbal fluency among rural older adults, and structural brain markers could partially mediate the association.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Geriatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Geriatrics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Annan medicin och hälsovetenskap -- Gerontologi, medicinsk/hälsovetenskaplig inriktning (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Other Medical and Health Sciences -- Gerontology, specialising in Medical and Health Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- Accelerometer
- Alzheimer's disease
- brain aging
- cognition
- magnetic resonance imaging
- population-based study
- sedentary behavior patterns
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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- Av författaren/redakt...
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Han, Xiaolei
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Song, Lin
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Li, Yuanjing
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Dong, Yi
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Liu, Rui
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Han, Qi
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Wang, Xiaojie
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Mao, Ming
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Cong, Lin
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Tang, Shi
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Hou, Tingting
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Zhang, Qinghua
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Liu, Cuicui
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Han, Xiaodong
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Shi, Lin
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Nyberg, Lars, 19 ...
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Launer, Lenore J ...
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Wang, Yongxiang
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Du, Yifeng
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Qiu, Chengxuan
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- MEDICIN OCH HÄLSOVETENSKAP
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och Geriatrik
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Neurologi
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Annan medicin oc ...
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och Gerontologi medi ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Neurovetenskaper
- Artiklar i publikationen
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Journal of Alzhe ...
- Av lärosätet
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Umeå universitet
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Stockholms universitet
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Karolinska Institutet