Rationale, design and baseline characteristics of the effect of ticagrelor on health outcomes in diabetes mellitus patients Intervention study

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Fältnamn	Indikatorer	Metadata
000		08828naa a2201501 4500
001		oai:DiVA.org:uu-387294
003		SwePub
008		190624s2019 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3872942 URI
024	7	a https://doi.org/10.1002/clc.231642 DOI
040		a (SwePub)uu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Bhatt, Deepak L.u Harvard Med Sch, Brigham & Womens Hosp, Heart & Vasc Ctr, 75 Francis St, Boston, MA 02115 USA4 aut
245	1 0	a Rationale, design and baseline characteristics of the effect of ticagrelor on health outcomes in diabetes mellitus patients Intervention study
264		c 2019-04-09
264	1	b Wiley,c 2019
338		a electronic2 rdacarrier
520		a In the setting of prior myocardial infarction, the oral antiplatelet ticagrelor added to aspirin reduced the risk of recurrent ischemic events, especially, in those with diabetes mellitus. Patients with stable coronary disease and diabetes are also at elevated risk and might benefit from dual antiplatelet therapy. The Effect of Ticagrelor on Health Outcomes in diabEtes Mellitus patients Intervention Study (THEMIS, NCT01991795) is a Phase 3b randomized, double-blinded, placebo-controlled trial of ticagrelor vs placebo, on top of low dose aspirin. Patients >= 50 years with type 2 diabetes receiving anti-diabetic medications for at least 6 months with stable coronary artery disease as determined by a history of previous percutaneous coronary intervention, bypass grafting, or angiographic stenosis of >= 50% of at least one coronary artery were enrolled. Patients with known prior myocardial infarction (MI) or stroke were excluded. The primary efficacy endpoint is a composite of cardiovascular death, myocardial infarction, or stroke. The primary safety endpoint is Thrombolysis in Myocardial Infarction major bleeding. A total of 19 220 patients worldwide have been randomized and at least 1385 adjudicated primary efficacy endpoint events are expected to be available for analysis, with an expected average follow-up of 40 months (maximum 58 months). Most of the exposure is on a 60 mg twice daily dose, as the dose was lowered from 90 mg twice daily partway into the study. The results may revise the boundaries of efficacy for dual antiplatelet therapy and whether it has a role outside acute coronary syndromes, prior myocardial infarction, or percutaneous coronary intervention.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
653		a antiplatelet therapy
653		a clinical trials
653		a diabetes mellitus
653		a general clinical cardiology
653		a adult
653		a ischemic heart disease
700	1	a Fox, Kimu Imperial Coll, Natl Heart & Lung Inst, London, England;Royal Brompton Hosp, London, England4 aut
700	1	a Harrington, Robert A.u Stanford Univ, Dept Med, SCCR, Stanford, CA 94305 USA4 aut
700	1	a Leiter, Lawrence A.u Univ Toronto, St Michaels Hosp, Li Ka Shing Knowledge Inst, Toronto, ON, Canada4 aut
700	1	a Mehta, Shamir R.u Hamilton Hlth Sci, Populat Hlth Res Inst, Hamilton, ON, Canada;McMaster Univ, Hamilton, ON, Canada4 aut
700	1	a Simon, Tabassomeu Sorbonne Univ Paris, Hop St Antoine, AP HP, Dept Clin Pharmacol URCEST, Paris, France4 aut
700	1	a Andersson, Marielleu AstraZeneca Gothenburg, Dept Cardiovasc Renal & Metab, Molndal, Sweden4 aut
700	1	a Himmelmann, Andersu AstraZeneca Gothenburg, Dept Cardiovasc Renal & Metab, Molndal, Sweden4 aut
700	1	a Ridderstrale, Wilhelmu AstraZeneca Gothenburg, Dept Cardiovasc Renal & Metab, Molndal, Sweden4 aut
700	1	a Held, Claes,d 1956-u Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kardiologi,Uppsala Univ, Uppsala Clin Res Ctr, Dept Med Sci, Cardiol, Uppsala, Sweden4 aut0 (Swepub:uu)clahe947
700	1	a Steg, Philippe Gabrielu Univ Paris Diderot, Hop Bichat, AP HP, Dept Hosp Univ FIRE,F CRIN Network,FACT, Paris, France;Univ Paris Diderot, Hop Bichat, AP HP, Dept Hosp Univ FIRE,INSERM,U 1148, Paris, France;Imperial Coll, Royal Brompton Hosp, NHLI, London, England4 aut
700	1	a Steg, Gabriel4 aut
700	1	a Diaz, Rafael4 aut
700	1	a Amerena, John4 aut
700	1	a Huber, Kurt4 aut
700	1	a Sinnaeve, Peter4 aut
700	1	a Nicolau, Jose Carlos4 aut
700	1	a Kerr Saraiva, Jose Francisco4 aut
700	1	a Petrov, Ivo4 aut
700	1	a Corbalan, Ramon4 aut
700	1	a Ge, Junbo4 aut
700	1	a Zhao, Qiang4 aut
700	1	a Botero, Rodrigo4 aut
700	1	a Widimsky, Petr4 aut
700	1	a Kristensen, Steen Dalby4 aut
700	1	a Hartikainen, Juha4 aut
700	1	a Danchin, Nicolas4 aut
700	1	a Darius, Harald4 aut
700	1	a Fat, Tse Hung4 aut
700	1	a Kiss, Robert Gabor4 aut
700	1	a Pais, Prem4 aut
700	1	a Lev, Eli4 aut
700	1	a De Luca, Leonardo4 aut
700	1	a Goto, Shinya4 aut
700	1	a Ramos Lopez, Gabriel Arturo4 aut
700	1	a Cornel, Jan Hein4 aut
700	1	a Kontny, Frederic4 aut
700	1	a Medina, Felix4 aut
700	1	a Babilonia, Noe4 aut
700	1	a Opolski, Grzegorz4 aut
700	1	a Vinereanu, Dragos4 aut
700	1	a Zateyshchikov, Dmitry4 aut
700	1	a Ruda, Mikhail4 aut
700	1	a Elamin, Omer4 aut
700	1	a Kovar, Frantisek4 aut
700	1	a Dalby, Anthony John4 aut
700	1	a Jeong, Myung Ho4 aut
700	1	a Bueno, Hector4 aut
700	1	a James, Stefan4 aut
700	1	a Chiang, Chern-En4 aut
700	1	a Tresukosol, Damras4 aut
700	1	a Ongen, Zeki4 aut
700	1	a Ray, Kausik4 aut
700	1	a Parkhomenko, Alexander4 aut
700	1	a McGuire, Darren4 aut
700	1	a Kosiborod, Mikhail4 aut
700	1	a Nguyen, Tuan Quang4 aut
700	1	a Wallentin, Lars4 aut
700	1	a Fox, Keith A. A.4 aut
700	1	a Eikelboom, John W.4 aut
700	1	a Tuomilehto, Jaakko4 aut
700	1	a Lee, Kerry L.4 aut
700	1	a Al-Khalidi, Hussein R.4 aut
700	1	a Ellis, Stephen J.4 aut
700	1	a Hagström, Emilu Uppsala universitet,Uppsala kliniska forskningscentrum (UCR)4 aut0 (Swepub:uu)emhag677
700	1	a Holmgren, Pernillau Uppsala universitet,Uppsala kliniska forskningscentrum (UCR)4 aut0 (Swepub:uu)perde159
700	1	a Heldestad, Ulrikau Uppsala universitet,Uppsala kliniska forskningscentrum (UCR)4 aut
700	1	a Hallberg, Theresau Uppsala universitet,Uppsala kliniska forskningscentrum (UCR)4 aut0 (Swepub:uu)theha265
700	1	a Renlund Grausne, Karinu Uppsala universitet,Uppsala kliniska forskningscentrum (UCR)4 aut0 (Swepub:uu)kargr743
700	1	a Alm, Cristinau Uppsala universitet,Uppsala kliniska forskningscentrum (UCR)4 aut0 (Swepub:uu)crial718
700	1	a Michelgård Palmquist, Åsa,d 1973-u Uppsala universitet,Uppsala kliniska forskningscentrum (UCR)4 aut0 (Swepub:uu)asmic254
700	1	a Svanberg, Camillau Uppsala universitet,Uppsala kliniska forskningscentrum (UCR)4 aut0 (Swepub:uu)camsv695
700	1	a Capell, Warren H.4 aut
700	1	a Nehler, Mark R.4 aut
700	1	a Hiatt, William R.4 aut
700	1	a Bonaca, Marc P.4 aut
700	1	a Houser, Stacey4 aut
700	1	a Bachler, Susie4 aut
700	1	a Jaeger, Nicole4 aut
700	1	a Aunes, Maria4 aut
700	1	a Brusehed, Asa4 aut
700	1	a Chen, Jersey4 aut
700	1	a Dahlof, Bjorn4 aut
700	1	a Dolezalova, Jitka4 aut
700	1	a Domzol, Maciej4 aut
700	1	a Findley, Magdalena4 aut
700	1	a Holmberg, Niclas4 aut
700	1	a Jahreskog, Marianne4 aut
700	1	a Knutsson, Mikael4 aut
700	1	a Kruszewski, Jakub4 aut
700	1	a Leonsson-Zachrisson, Maria4 aut
700	1	a Stark, Maj4 aut
700	1	a Winder, Elin4 aut
710	2	a Harvard Med Sch, Brigham & Womens Hosp, Heart & Vasc Ctr, 75 Francis St, Boston, MA 02115 USAb Imperial Coll, Natl Heart & Lung Inst, London, England;Royal Brompton Hosp, London, England4 org
773	0	t Clinical Cardiologyd : Wileyg 42:5, s. 498-505q 42:5<498-505x 0160-9289x 1932-8737
856	4	u https://doi.org/10.1002/clc.23164y Fulltext
856	4	u https://uu.diva-portal.org/smash/get/diva2:1329025/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
856	4	u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/clc.23164
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-387294
856	4 8	u https://doi.org/10.1002/clc.23164

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Av författaren/redakt...: Bhatt, Deepak L.; Fox, Kim; Harrington, Robe ...; Leiter, Lawrence ...; Mehta, Shamir R.; Simon, Tabassome; visa fler...; Andersson, Marie ...; Himmelmann, Ande ...; Ridderstrale, Wi ...; Held, Claes, 195 ...; Steg, Philippe G ...; Steg, Gabriel; Diaz, Rafael; Amerena, John; Huber, Kurt; Sinnaeve, Peter; Nicolau, Jose Ca ...; Kerr Saraiva, Jo ...; Petrov, Ivo; Corbalan, Ramon; Ge, Junbo; Zhao, Qiang; Botero, Rodrigo; Widimsky, Petr; Kristensen, Stee ...; Hartikainen, Juh ...; Danchin, Nicolas; Darius, Harald; Fat, Tse Hung; Kiss, Robert Gab ...; Pais, Prem; Lev, Eli; De Luca, Leonard ...; Goto, Shinya; Ramos Lopez, Gab ...; Cornel, Jan Hein; Kontny, Frederic; Medina, Felix; Babilonia, Noe; Opolski, Grzegor ...; Vinereanu, Drago ...; Zateyshchikov, D ...; Ruda, Mikhail; Elamin, Omer; Kovar, Frantisek; Dalby, Anthony J ...; Jeong, Myung Ho; Bueno, Hector; James, Stefan; Chiang, Chern-En; Tresukosol, Damr ...; Ongen, Zeki; Ray, Kausik; Parkhomenko, Ale ...; McGuire, Darren; Kosiborod, Mikha ...; Nguyen, Tuan Qua ...; Wallentin, Lars; Fox, Keith A. A.; Eikelboom, John ...; Tuomilehto, Jaak ...; Lee, Kerry L.; Al-Khalidi, Huss ...; Ellis, Stephen J ...; Hagström, Emil; Holmgren, Pernil ...; Heldestad, Ulrik ...; Hallberg, Theres ...; Renlund Grausne, ...; Alm, Cristina; Michelgård Palmq ...; Svanberg, Camill ...; Capell, Warren H ...; Nehler, Mark R.; Hiatt, William R ...; Bonaca, Marc P.; Houser, Stacey; Bachler, Susie; Jaeger, Nicole; Aunes, Maria; Brusehed, Asa; Chen, Jersey; Dahlof, Bjorn; Dolezalova, Jitk ...; Domzol, Maciej; Findley, Magdale ...; Holmberg, Niclas; Jahreskog, Maria ...; Knutsson, Mikael; Kruszewski, Jaku ...; Leonsson-Zachris ...; Stark, Maj; Winder, Elin; visa färre...

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