Sökning: WFRF:(Dencker L.) > (2005-2009) > Cadmium-induced gen...
Fältnamn | Indikatorer | Metadata |
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000 | 02956naa a2200445 4500 | |
001 | oai:DiVA.org:uu-93851 | |
003 | SwePub | |
008 | 051128s2006 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-938512 URI |
024 | 7 | a https://doi.org/10.1016/j.reprotox.2006.05.0072 DOI |
040 | a (SwePub)uu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Kultima, Kimu Uppsala universitet,Avdelningen för toxikologi4 aut0 (Swepub:uu)kikul535 |
245 | 1 0 | a Cadmium-induced gene expression changes in the mouse embryo, and the influence of pretreatment with zinc |
264 | 1 | b Elsevier BV,c 2006 |
338 | a print2 rdacarrier | |
520 | a Cadmium (Cd) administered to female C57BL/6 mice on gestation day 8 induces a high incidence of anterior neural tube defects (exencephaly). This adverse effect can be attenuated by maternal pretreatment with zinc (Zn). In this study we used replicated microarray analysis and real-time PCR to investigate gene expression changes induced in the embryo 5 and 10h after maternal Cd exposure in the absence or presence of Zn pretreatment. We report nine genes with a transcriptional response induced by Cd, none of which was influenced by Zn pretreatment, and two genes induced only by combined matemal Cd exposure and Zn pretreatment. We discuss the results in relation to the possibility that Cd is largely excluded from the embryo, that the teratogenic effects of Cd may be secondary to toxicity in extraembryonic tissues, and that the primary protective role of Zn may not be to reverse Cd-induced transcription in the embryo. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Farmaceutiska vetenskaper0 (SwePub)301012 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Pharmaceutical Sciences0 (SwePub)301012 hsv//eng |
653 | a cadmium | |
653 | a exencephaly | |
653 | a microarray | |
653 | a mouse embryo | |
653 | a neural tube defects | |
653 | a toxicogenomics | |
653 | a zinc | |
653 | a PHARMACY | |
653 | a FARMACI | |
700 | 1 | a Fernández, Estíbaliz L.u Uppsala universitet,Avdelningen för toxikologi4 aut |
700 | 1 | a Scholz, Birgeru Uppsala universitet,Avdelningen för toxikologi4 aut0 (Swepub:uu)bisch677 |
700 | 1 | a Gustafson, Anne-Lee4 aut |
700 | 1 | a Dencker, Lennartu Uppsala universitet,Avdelningen för toxikologi4 aut0 (Swepub:uu)lenndenc |
700 | 1 | a Stigson, Michaelu Uppsala universitet,Avdelningen för toxikologi4 aut0 (Swepub:uu)michstig |
710 | 2 | a Uppsala universitetb Avdelningen för toxikologi4 org |
773 | 0 | t Reproductive Toxicologyd : Elsevier BVg 22:4, s. 636-646q 22:4<636-646x 0890-6238x 1873-1708 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-93851 |
856 | 4 8 | u https://doi.org/10.1016/j.reprotox.2006.05.007 |
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