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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004429naa a2200469 4500
001oai:lup.lub.lu.se:79ef5c8a-b0e1-4d71-ba6d-27cc3e00a042
003SwePub
008210716s2021 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/79ef5c8a-b0e1-4d71-ba6d-27cc3e00a0422 URI
0247 a https://doi.org/10.1089/neu.2020.73172 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Karlsson, Michaelu Lund University,Lunds universitet,Mitokondriell Medicin,Forskargrupper vid Lunds universitet,Mitochondrial Medicine,Lund University Research Groups,Copenhagen University Hospital,Cochin Hospital4 aut0 (Swepub:lu)med-mck
2451 0a Evaluation of Diffusion Tensor Imaging and Fluid Based Biomarkers in a Large Animal Trial of Cyclosporine in Focal Traumatic Brain Injury
264 1b Mary Ann Liebert Inc,c 2021
300 a 9 s.
520 a All phase III trials evaluating medical treatments for traumatic brain injury (TBI), performed to date, have failed. To facilitate future success there is a need for novel outcome metrics that can bridge pre-clinical studies to clinical proof of concept trials. Our objective was to assess diffusion tensor imaging (DTI) and biofluid-based biomarkers as efficacy outcome metrics in a large animal study evaluating the efficacy of cyclosporine in TBI. This work builds on our previously published study that demonstrated a reduced volume of injury by 35% with cyclosporine treatment based on magnetic resonance imaging (MRI) results. A focal contusion injury was induced in piglets using a controlled cortical impact (CCI) device. Cyclosporine in a novel Cremophor/Kolliphor EL-free lipid emulsion, NeuroSTAT, was administered by continuous intravenous infusion for 5 days. The animals underwent DTI on day 5. Glial fibrillary acidic protein (GFAP), as a measure of astroglia injury, and neurofilament light (NF-L), as a measure of axonal injury, were measured in blood on days 1, 2, and 5, and in cerebrospinal fluid (CSF) on day 5 post-injury. Normalized fractional anisotropy (FA) was significantly (p = 0.027) higher in in the treatment group, indicating preserved tissue integrity with treatment. For the biomarkers, we observed a statistical trend of a decreased level of NF-L in CSF (p = 0.051), in the treatment group relative to placebo, indicating less axonal injury. Our findings suggest that DTI, and possibly CSF NF-L, may be feasible as translational end-points assessing neuroprotective drugs in TBI.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng
653 a biomarkers
653 a cyclosporine
653 a diffusion tensor imaging
653 a traumatic brain injury
7001 a Yang, Zhihuiu Florida Museum Natural History4 aut
7001 a Chawla, Sanjeevu Cochin Hospital4 aut
7001 a Delso, Nileu Cochin Hospital4 aut
7001 a Pukenas, Bryanu Cochin Hospital4 aut
7001 a Elmér, Eskilu Lund University,Lunds universitet,Mitokondriell Medicin,Forskargrupper vid Lunds universitet,Mitochondrial Medicine,Lund University Research Groups,Abliva AB4 aut0 (Swepub:lu)expb-eel
7001 a Hugerth, Matildau Abliva AB4 aut
7001 a Margulies, Susan S.u Georgia Institute of Technology4 aut
7001 a Ehinger, Johannesu Lund University,Lunds universitet,Mitokondriell Medicin,Forskargrupper vid Lunds universitet,Mitochondrial Medicine,Lund University Research Groups4 aut0 (Swepub:lu)med-jeg
7001 a Hansson, Magnus J.u Lund University,Lunds universitet,Mitokondriell Medicin,Forskargrupper vid Lunds universitet,Mitochondrial Medicine,Lund University Research Groups,Abliva AB4 aut0 (Swepub:lu)expb-mha
7001 a Wang, Kevin K.W.u Florida Museum Natural History4 aut
7001 a Kilbaugh, Todd J.u Cochin Hospital4 aut
7102 a Mitokondriell Medicinb Forskargrupper vid Lunds universitet4 org
7730 t Journal of Neurotraumad : Mary Ann Liebert Incg 38:13, s. 1870-1878q 38:13<1870-1878x 0897-7151x 1557-9042
8564 u http://dx.doi.org/10.1089/neu.2020.7317y FULLTEXT
8564 8u https://lup.lub.lu.se/record/79ef5c8a-b0e1-4d71-ba6d-27cc3e00a042
8564 8u https://doi.org/10.1089/neu.2020.7317

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