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Sökning: WFRF:(Franke James) > (2015-2019) > High-density mappin...

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FältnamnIndikatorerMetadata
00007676naa a2200637 4500
001oai:DiVA.org:oru-50332
003SwePub
008160518s2015 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:130633341
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-503322 URI
0247 a https://doi.org/10.1038/ng.31762 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1306333412 URI
040 a (SwePub)orud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Goyette, Philippeu Research Center, Montreal Heart Institute, Montreal QC, Canada4 aut
2451 0a High-density mapping of the MHC identifies a shared role for HLA-DRB1*01 :b 03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis
264 c 2015-01-05
264 1a New York, USA :b Nature Publishing Group,c 2015
338 a print2 rdacarrier
520 a Genome-wide association studies of the related chronic inflammatory bowel diseases (IBD) known as Crohn's disease and ulcerative colitis have shown strong evidence of association to the major histocompatibility complex (MHC). This region encodes a large number of immunological candidates, including the antigen-presenting classical human leukocyte antigen (HLA) molecules. Studies in IBD have indicated that multiple independent associations exist at HLA and non-HLA genes, but they have lacked the statistical power to define the architecture of association and causal alleles. To address this, we performed high-density SNP typing of the MHC in >32,000 individuals with IBD, implicating multiple HLA alleles, with a primary role for HLA-DRB1*01:03 in both Crohn's disease and ulcerative colitis. Noteworthy differences were observed between these diseases, including a predominant role for class II HLA variants and heterozygous advantage observed in ulcerative colitis, suggesting an important role of the adaptive immune response in the colonic environment in the pathogenesis of IBD.
650 7a NATURVETENSKAPx Biologix Genetik0 (SwePub)106092 hsv//swe
650 7a NATURAL SCIENCESx Biological Sciencesx Genetics0 (SwePub)106092 hsv//eng
7001 a Boucher, Gabrielleu Research Center, Montreal Heart Institute, Montreal QC, Canada4 aut
7001 a Mallon, Dermotu Department of Surgery, University of Cambridge, Cambridge, UK; National Institute for Health Research (NIHR) Cambridge Biomedical Research Centre, Cambridge, UK4 aut
7001 a Ellinghaus, Evau Institute of Clinical Molecular Biology, Christian Albrechts University, Kiel, Germany4 aut
7001 a Jostins, Lukeu Wellcome Trust Centre for Human Genetics, University of Oxford, Headington, UK; Christ Church, University of Oxford, Oxford, UK4 aut
7001 a Huang, Hailiangu Analytic and Translational Genetics Unit, Massachusetts General Hospital, Harvard Medical School, Boston MA, USA; Broad Institute of MIT and Harvard, Cambridge MA, USA4 aut
7001 a Ripke, Stephanu Analytic and Translational Genetics Unit, Massachusetts General Hospital, Harvard Medical School, Boston MA, USA; Broad Institute of MIT and Harvard, Cambridge MA, USA4 aut
7001 a Gusareva, Elena S.u Systems and Modeling Unit, Montefiore Institute, University of Liege, Liege, Belgium; Bioinformatics and Modeling, GIGA-R (Groupe Interdisciplinaire de Génoprotéomique Appliquée) Research Center, University of Liege, Liege, Belgium4 aut
7001 a Annese, Vitou Unit of Gastroenterology, IRCCS-CSS (Istituto di Ricovero e Cura a Carattere Scientifico–Casa Sollievo della Sofferenza) Hospital, San Giovanni Rotondo, Italy; Unit of Gastroenterology SOD2 (Strutture Organizzative Dipartimentali), Azienda Ospedaliero Universitaria (AOU) Careggi, Florence, Italy4 aut
7001 a Hauser, Stephen L.u Department of Neurology, University of California, San Francisco, USA4 aut
7001 a Oksenberg, Jorge R.u Department of Neurology, University of California,San Francisco, USA4 aut
7001 a Thomsen, Ingou Institute of Clinical Molecular Biology, Christian Albrechts University, Kiel, Germany4 aut
7001 a Leslie, Stephenu Murdoch Children's Research Institute, Parkville Vic, Australia; Department of Mathematics and Statistics, University of Melbourne, Melbourne Vic, Australia4 aut
7001 a Daly, Mark J.u Analytic and Translational Genetics Unit, Massachusetts General Hospital, Harvard Medical School, Boston MA, USA; Broad Institute of MIT and Harvard, Cambridge MA, USA4 aut
7001 a Van Steen, Kristelu Systems and Modeling Unit, Montefiore Institute, University of Liege, Liege, Belgium; Bioinformatics and Modeling, GIGA-R (Groupe Interdisciplinaire de Génoprotéomique Appliquée) Research Center, University of Liege, Liege, Belgium4 aut
7001 a Duerr, Richard H.u Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh PA, USA; Department of Human Genetics, University of Pittsburgh Graduate School of Public Health, Pittsburgh PA, USA4 aut
7001 a Barrett, Jeffrey C.u Wellcome Trust Sanger Institute, Hinxton, UK4 aut
7001 a McGovern, Dermot P. B.4 aut
7001 a Schumm, L. Philipu Department of Public Health Sciences, University of Chicago, Chicago ILL, USA4 aut
7001 a Traherne, James A.u Cambridge Institute for Medical Research, Cambridge, UK; Department of Pathology, University of Cambridge, Cambridge, UK4 aut
7001 a Carrington, Mary N.u Cancer and Inflammation Program, Laboratory of Experimental Immunology, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick MD, USA; Ragon Institute of Massachusetts General Hospital, MIT and Harvard, Cambridge MA, USA4 aut
7001 a Kosmoliaptsis, Vasilisu Department of Surgery, University of Cambridge, Cambridge, UK; National Institute for Health Research (NIHR) Cambridge Biomedical Research Centre, Cambridge, UK4 aut
7001 a Karlsen, Tom H.u Research Institute of Internal Medicine, Department of Transplantation Medicine, Division of Cancer, Surgery and Transplantation, Oslo University Hospital (Rikshospitalet), Oslo, Norway; Norwegian Primary Sclerosing Cholangitis Research Center, Department of Transplantation Medicine, Division of Cancer, Surgery and Transplantation, Oslo University Hospital (Rikshospitalet), Oslo, Norway4 aut
7001 a Franke, Andreu Institute of Clinical Molecular Biology, Christian Albrechts University, Kiel, Germany4 aut
7001 a Rioux, John D.u Research Center, Montreal Heart Institute, Montreal QC, Canada; Faculté de Médecine, Université de Montréal, Montreal QC, Canada4 aut
7001 a Halfvarson, Jonas,d 1970-u Örebro universitet,Institutionen för medicinska vetenskaper,Department of Medicine, Örebro University Hospital, Örebro, Sweden4 ctb0 (Swepub:oru)jshn
7102 a Research Center, Montreal Heart Institute, Montreal QC, Canadab Department of Surgery, University of Cambridge, Cambridge, UK; National Institute for Health Research (NIHR) Cambridge Biomedical Research Centre, Cambridge, UK4 org
7730 t Nature Geneticsd New York, USA : Nature Publishing Groupg 47:2, s. 172-179q 47:2<172-179x 1061-4036x 1546-1718
8564 u https://scholarlypublications.universiteitleiden.nl/access/item%3A2995139/view
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-50332
8564 8u https://doi.org/10.1038/ng.3176
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:130633341

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