Differences in health related quality of life in the randomised ARTSCAN study; accelerated vs. conventional radiotherapy for head and neck cancer. A five year follow up

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Differences in health related quality of life in the randomised ARTSCAN study; accelerated vs. conventional radiotherapy for head and neck cancer. A five year follow up

Nyqvist, Johanna (author): Umeå universitet,Öron- näs- och halssjukdomar,Department of Otolaryngology and Head and Neck Surgery, Skåne University Hospital, Lund

Fransson, Per (author): Umeå University,Umeå universitet,Institutionen för omvårdnad

Laurell, Göran (author): Umeå University,Umeå universitet,Uppsala universitet,Öron-, näs- och halssjukdomar,Umea Univ, Dept Clin Sci Otolaryngol & Head & Neck Surg, S-90187 Umea, Sweden.,Öron- näs- och halssjukdomar,Department of Otolaryngology and Head and Neck Surgery, Uppsala University Hospital

Hammerlid, Eva (author): Sahlgrens Univ Hosp, Dept Otolaryngol & Head & Neck Surg, Gothenburg, Sweden.,Sahlgrenska University Hospital

Kjellén, Elisabeth (author): Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital

Franzén, Lars (author): Umeå University,Umeå universitet,Onkologi

Söderström, Karin (author): Umeå University,Umeå universitet,Onkologi

Wickart-Johansson, Gun (author): Karolinska Univ Hosp, Dept Oncol, Stockholm, Sweden.,Karolinska University Hospital

Friesland, Signe (author): Karolinska Institutet

Sjodin, Helena (author): Karolinska Univ Hosp, Dept Oncol, Stockholm, Sweden.,Karolinska University Hospital

Brun, Eva (author): Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital

Ask, Anders (author): Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital

Nilsson, Per (author): Lund University,Lunds universitet,Medicinsk strålningsfysik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medical Radiation Physics, Lund,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital

Ekberg, Lars (author): Lund Univ, Skane Univ Hosp, Dept Oncol & Radiat Phys, S-22100 Lund, Sweden.,Skåne University Hospital

Bjork-Eriksson, Thomas (author): Sahlgrens Univ Hosp, Dept Oncol, Gothenburg, Sweden.

Nyman, Jan (author): Sahlgrens Univ Hosp, Dept Oncol, Gothenburg, Sweden.

Loden, Britta (author): Karlstad Cent Hosp, Dept Clin Oncol, Karlskrona, Sweden.

Lewin, Freddi (author): Ryhov Cty Hosp, Dept Oncol, Jonkoping, Sweden.

Reizenstein, Johan (author): Orebro Univ Hosp, Dept Oncol, Orebro, Sweden.

Lundin, Erik (author): Ryhov Cty Hosp, Dept Oncol, Jonkoping, Sweden.

Zackrisson, Björn (author): Umeå universitet,Onkologi

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Elsevier BV, 2016
2016
English.
In: Radiotherapy and Oncology. - : Elsevier BV. - 0167-8140 .- 1879-0887. ; 118:2, s. 335-341

Related links:: http://www.ncbi.nlm....; show more...; http://dx.doi.org/10...; https://urn.kb.se/re...; https://doi.org/10.1...; https://urn.kb.se/re...; https://lup.lub.lu.s...; http://kipublication...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

Background and purpose: Health related quality of life (HRQoL) was assessed in the randomised, prospective ARTSCAN study comparing conventional radiotherapy (CF) with accelerated radiotherapy (AF) for head and neck cancer. Material and methods: 750 patients with squamous cell carcinoma (of any grade and stage) in the oral cavity, oro-, or hypopharynx or larynx (except T1-2, NO glottic carcinoma) without distant metastases were randomised to either conventional fractionation (2 Gy/day, 5 days/week in 49 days, total dose 68 Gy) or accelerated fractionation (1.1 + 2.0 Gy/day, 5 days/week in 35 days, total dose 68 Gy). HRQoL was assessed with EORTC QLQ-C30, QLQ-H&N35 and HADS at baseline, at end of radiotherapy (eRT) and at 3 and 6 months and 1, 2 and 5 years after start of treatment. Results: The AF group reported HRQoL was significantly lower at eRT and at 3 months for most symptoms, scales and functions. Few significant differences were noted between the groups at 6 months and 5 years. Scores related to functional oral intake never reached baseline. Conclusion: In comparison to CF, AF has a stronger adverse effect on HRQoL in the acute phase.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Omvårdnad (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nursing (hsv//eng)

Keyword

Health related quality of life
Accelerated radiotherapy
Head and neck cancer
Quality of life
Accelerated fractionation

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art (subject category)

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cancer and Oncol ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Radiology Nuclea ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Health Sciences; and Nursing

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By the university: Uppsala University; Umeå University; Lund University; Karolinska Institutet

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