A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium

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Fältnamn	Indikatorer	Metadata
000		05719naa a2201249 4500
001		oai:lup.lub.lu.se:35ce7307-30b7-473b-894a-c603d9c2d2b0
003		SwePub
008		160401s2009 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://lup.lub.lu.se/record/15048532 URI
024	7	a https://doi.org/10.1038/ng.4672 DOI
040		a (SwePub)lu
041		a engb eng
042		9 SwePub
072	7	a art2 swepub-publicationtype
072	7	a ref2 swepub-contenttype
100	1	a Soranzo, Nicole4 aut
245	1 0	a A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium
264		c 2009-10-11
264	1	b Springer Science and Business Media LLC,c 2009
520		a The number and volume of cells in the blood affect a wide range of disorders including cancer and cardiovascular, metabolic, infectious and immune conditions. We consider here the genetic variation in eight clinically relevant hematological parameters, including hemoglobin levels, red and white blood cell counts and platelet counts and volume. We describe common variants within 22 genetic loci reproducibly associated with these hematological parameters in 13,943 samples from six European population-based studies, including 6 associated with red blood cell parameters, 15 associated with platelet parameters and 1 associated with total white blood cell count. We further identified a long-range haplotype at 12q24 associated with coronary artery disease and myocardial infarction in 9,479 cases and 10,527 controls. We show that this haplotype demonstrates extensive disease pleiotropy, as it contains known risk loci for type 1 diabetes, hypertension and celiac disease and has been spread by a selective sweep specific to European and geographically nearby populations.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
700	1	a Spector, Tim D.4 aut
700	1	a Mangino, Massimo4 aut
700	1	a Kuehnel, Brigitte4 aut
700	1	a Rendon, Augusto4 aut
700	1	a Teumer, Alexander4 aut
700	1	a Willenborg, Christina4 aut
700	1	a Wright, Benjamin4 aut
700	1	a Chen, Li4 aut
700	1	a Li, Mingyao4 aut
700	1	a Salo, Perttu4 aut
700	1	a Voight, Benjamin F.4 aut
700	1	a Burns, Philippa4 aut
700	1	a Laskowski, Roman A.4 aut
700	1	a Xue, Yali4 aut
700	1	a Menzel, Stephan4 aut
700	1	a Altshuler, David4 aut
700	1	a Bradley, John R.4 aut
700	1	a Bumpstead, Suzannah4 aut
700	1	a Burnett, Mary-Susan4 aut
700	1	a Devaney, Joseph4 aut
700	1	a Doering, Angela4 aut
700	1	a Elosua, Roberto4 aut
700	1	a Epstein, Stephen E.4 aut
700	1	a Erber, Wendy4 aut
700	1	a Falchi, Mario4 aut
700	1	a Garner, Stephen F.4 aut
700	1	a Ghori, Mohammed J. R.4 aut
700	1	a Goodall, Alison H.4 aut
700	1	a Gwilliam, Rhian4 aut
700	1	a Hakonarson, Hakon H.4 aut
700	1	a Hall, Alistair S.4 aut
700	1	a Hammond, Naomi4 aut
700	1	a Hengstenberg, Christian4 aut
700	1	a Illig, Thomas4 aut
700	1	a Koenig, Inke R.4 aut
700	1	a Knouff, Christopher W.4 aut
700	1	a McPherson, Ruth4 aut
700	1	a Melander, Olleu Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups4 aut0 (Swepub:lu)endo-ome
700	1	a Mooser, Vincent4 aut
700	1	a Nauck, Matthias4 aut
700	1	a Nieminen, Markku S.4 aut
700	1	a O'Donnell, Christopher J.4 aut
700	1	a Peltonen, Leena4 aut
700	1	a Potter, Simon C.4 aut
700	1	a Prokisch, Holger4 aut
700	1	a Rader, Daniel J.4 aut
700	1	a Rice, Catherine M.4 aut
700	1	a Roberts, Robert4 aut
700	1	a Salomaa, Veikko4 aut
700	1	a Sambrook, Jennifer4 aut
700	1	a Schreiber, Stefan4 aut
700	1	a Schunkert, Heribert4 aut
700	1	a Schwartz, Stephen M.4 aut
700	1	a Serbanovic-Canic, Jovana4 aut
700	1	a Sinisalo, Juha4 aut
700	1	a Siscovick, David S.4 aut
700	1	a Stark, Klaus4 aut
700	1	a Surakka, Ida4 aut
700	1	a Stephens, Jonathan4 aut
700	1	a Thompson, John R.4 aut
700	1	a Voelker, Uwe4 aut
700	1	a Voelzke, Henry4 aut
700	1	a Watkins, Nicholas A.4 aut
700	1	a Wells, George A.4 aut
700	1	a Wichmann, H-Erich4 aut
700	1	a Van Heel, David A.4 aut
700	1	a Tyler-Smith, Chris4 aut
700	1	a Thein, Swee Lay4 aut
700	1	a Kathiresan, Sekar4 aut
700	1	a Perola, Markus4 aut
700	1	a Reilly, Muredach P.4 aut
700	1	a Stewart, Alexandre F. R.4 aut
700	1	a Erdmann, Jeanette4 aut
700	1	a Samani, Nilesh J.4 aut
700	1	a Meisinger, Christa4 aut
700	1	a Greinacher, Andreas4 aut
700	1	a Deloukas, Panos4 aut
700	1	a Ouwehand, Willem H.4 aut
700	1	a Gieger, Christian4 aut
710	2	a Kardiovaskulär forskning - hypertonib Forskargrupper vid Lunds universitet4 org
773	0	t Nature Geneticsd : Springer Science and Business Media LLCg 41:11, s. 38-1182q 41:11<38-1182x 1546-1718x 1061-4036
856	4	u http://dx.doi.org/10.1038/ng.467y FULLTEXT
856	4	u https://europepmc.org/articles/pmc3108459?pdf=render
856	4 8	u https://lup.lub.lu.se/record/1504853
856	4 8	u https://doi.org/10.1038/ng.467

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Av författaren/redakt...: Soranzo, Nicole; Spector, Tim D.; Mangino, Massimo; Kuehnel, Brigitt ...; Rendon, Augusto; Teumer, Alexande ...; visa fler...; Willenborg, Chri ...; Wright, Benjamin; Chen, Li; Li, Mingyao; Salo, Perttu; Voight, Benjamin ...; Burns, Philippa; Laskowski, Roman ...; Xue, Yali; Menzel, Stephan; Altshuler, David; Bradley, John R.; Bumpstead, Suzan ...; Burnett, Mary-Su ...; Devaney, Joseph; Doering, Angela; Elosua, Roberto; Epstein, Stephen ...; Erber, Wendy; Falchi, Mario; Garner, Stephen ...; Ghori, Mohammed ...; Goodall, Alison ...; Gwilliam, Rhian; Hakonarson, Hako ...; Hall, Alistair S ...; Hammond, Naomi; Hengstenberg, Ch ...; Illig, Thomas; Koenig, Inke R.; Knouff, Christop ...; McPherson, Ruth; Melander, Olle; Mooser, Vincent; Nauck, Matthias; Nieminen, Markku ...; O'Donnell, Chris ...; Peltonen, Leena; Potter, Simon C.; Prokisch, Holger; Rader, Daniel J.; Rice, Catherine ...; Roberts, Robert; Salomaa, Veikko; Sambrook, Jennif ...; Schreiber, Stefa ...; Schunkert, Herib ...; Schwartz, Stephe ...; Serbanovic-Canic ...; Sinisalo, Juha; Siscovick, David ...; Stark, Klaus; Surakka, Ida; Stephens, Jonath ...; Thompson, John R ...; Voelker, Uwe; Voelzke, Henry; Watkins, Nichola ...; Wells, George A.; Wichmann, H-Eric ...; Van Heel, David ...; Tyler-Smith, Chr ...; Thein, Swee Lay; Kathiresan, Seka ...; Perola, Markus; Reilly, Muredach ...; Stewart, Alexand ...; Erdmann, Jeanett ...; Samani, Nilesh J ...; Meisinger, Chris ...; Greinacher, Andr ...; Deloukas, Panos; Ouwehand, Willem ...; Gieger, Christia ...; visa färre...

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