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Increased aortic pu...
Increased aortic pulse wave velocity in middle-aged women with systemic lupus erythematosus
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- Bjarnegård, Niclas (författare)
- Linköpings universitet,Institutionen för medicin och hälsa,Hälsouniversitetet
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- Bengtsson, Christine (författare)
- Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Department of Rheumatology, Lund University Hospital, Lund, Sweden
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- Brodszki, Jana (författare)
- Lund University,Lunds universitet,Obstetrik och gynekologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Obstetrics and Gynaecology (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Department of Women’s Health, Lund University Hospital, Lund, Sweden
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- Sturfelt, Gunnar (författare)
- Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Department of Rheumatology, Lund University Hospital, Lund, Sweden
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- Nived, Ola (författare)
- Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Department of Rheumatology, Lund University Hospital, Lund, Sweden
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- Länne, Toste (författare)
- Linköpings universitet,Fysiologi,Hälsouniversitetet
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(creator_code:org_t)
- 2016-07-02
- 2006
- Engelska.
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Ingår i: Lupus. - : SAGE Publications. - 0961-2033 .- 1477-0962. ; 15:10, s. 644-650
- Relaterad länk:
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http://urn.kb.se/res...
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- Systemic lupus erythematosus (SLE) is a connective tissue disease where inflammatory activity affects several organ systems. An increased risk of cardiovascular disease has been identified in these patients, even after correction for traditional risk factors. The aim of the present study was to evaluate arterial stiffness and central hemodynamics in women with SLE in comparison to controls. Arterial tonometry was used to measure aortic (carotid-femoral) and arm (carotid-radial) pulse wave velocity (PWV), reflected pressure waves, and aortic augmentation index (AIx) in 27 women with SLE (52 to 68 years) and 27 controls. Aortic PWV was higher in women with SLE than controls, 9.8 m/s versus 8.2 m/s (P 0.01), after correction for mean arterial pressure and body mass index, 9.5 m/s versus 8.5 m/s (P 0.05). Other parameters were similar, arm PWV, 8.4 versus 8.5 m/s, AIx 34 versus 33% and calculated central aortic pulse pressure 48 versus 43 mmHg, in SLE and controls, respectively (NS). Aortic PWV was positively associated to C-reactive protein (CRP) and complement factor 3 (C3). Women with SLE have increased stiffness of their elastic central arteries. This may be one factor contributing to the increased cardiovascular risk seen in this cohort.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Nyckelord
- arteries
- blood pressure
- elasticity
- pulse
- SLE
- women
- MEDICINE
- MEDICIN
- arteries
- blood pressure
- elasticity
- pulse
- SLE
- women
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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