WFRF:(Roos Per M.)
Search: WFRF:(Roos Per M.) > Metal ratios as pos...
- 17 of 41
- Previous record
- Next record
- To hitlist
| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03647naa a2200457 4500 | |
| 001 | oai:DiVA.org:su-217137 | |
| 003 | SwePub | |
| 008 | 230517s2023 | |||||||||||000 ||eng| | |
| 009 | oai:prod.swepub.kib.ki.se:152429446 | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-2171372 URI |
| 024 | 7 | a https://doi.org/10.1016/j.jtemb.2023.1271632 DOI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1524294462 URI |
| 040 | a (SwePub)sud (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Koski, Lassi4 aut |
| 245 | 1 0 | a Metal ratios as possible biomarkers for amyotrophic lateral sclerosis |
| 264 | 1 | b Elsevier BV,c 2023 |
| 338 | a print2 rdacarrier | |
| 520 | a Background and Objectives: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with unknown aetiology. Metals have been suspected to contribute to ALS pathogenesis since mid-19th century, yet studies on measured metal concentrations in ALS patients have often yielded conflicting results, with large individual variation in measured values. Calculating metal concentration ratios can unveil possible synergistic effects of neurotoxic metals in ALS pathogenesis. The aim of this study was to investigate if ratios of different metal concentrations in cerebrospinal fluid (CSF) and blood plasma, respectively, differ between ALS patients and healthy controls.Methods: Cerebrospinal fluid and blood plasma were collected from 17 ALS patients and 10 controls. Samples were analysed for 22 metals by high-resolution inductively coupled plasma mass spectrometry (HR-ICP-MS), and all possible 231 metal ratios calculated in each body fluid.Results: Fifty-three metal ratios were significantly elevated in ALS cases as compared to controls (p < 0.05); five in blood plasma, and 48 in CSF. The finding of fewer elevated ratios in blood plasma may indicate specific transport of metals into the central nervous system. The elevated metal ratios in CSF include Cd/Se (p = 0.031), and 16 ratios with magnesium, such as Mn/Mg (p = 0.005) and Al/Mg (p = 0.014).Conclusion: Metal ratios may be used as biomarkers in ALS diagnosis and as guidelines for preventive measures. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng |
| 650 | 7 | a NATURVETENSKAPx Kemi0 (SwePub)1042 hsv//swe |
| 650 | 7 | a NATURAL SCIENCESx Chemical Sciences0 (SwePub)1042 hsv//eng |
| 653 | a Neurodegeneration | |
| 653 | a Neurotoxicity | |
| 653 | a Neuroprotection | |
| 653 | a Ratio | |
| 653 | a Metal exposure | |
| 700 | 1 | a Berntsson, Elinau Stockholms universitet,Institutionen för biokemi och biofysik,Tallinn University of Technology, Estonia4 aut0 (Swepub:su)elbe7262 |
| 700 | 1 | a Vikström, Max4 aut |
| 700 | 1 | a Wärmländer, Sebastian K. T. S.,d 1970-u Stockholms universitet,Institutionen för biokemi och biofysik4 aut0 (Swepub:su)seb |
| 700 | 1 | a Roos, Per M.u Karolinska Institutet4 aut |
| 710 | 2 | a Stockholms universitetb Institutionen för biokemi och biofysik4 org |
| 773 | 0 | t Journal of Trace Elements in Medicine and Biologyd : Elsevier BVg 78q 78x 0946-672Xx 1878-3252 |
| 856 | 4 | u https://doi.org/10.1016/j.jtemb.2023.127163y Fulltext |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-217137 |
| 856 | 4 8 | u https://doi.org/10.1016/j.jtemb.2023.127163 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:152429446 |
Find in a library
- Journal of Trace Elements in Medicine and Biology (Search for host publication in LIBRIS)
To the university's database
- 17 of 41
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Koski, Lassi
- Berntsson, Elina
- Vikström, Max
- Wärmländer, Seba ...
- Roos, Per M.
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Clinical Medicin ...
- and Neurology
-
- NATURAL SCIENCES
- NATURAL SCIENCES
- and Chemical Science ...
- Articles in the publication
- Journal of Trace ...
- By the university
- Stockholm University
- Karolinska Institutet
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
