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WFRF:(Rylander Gunnar)
 

Sökning: WFRF:(Rylander Gunnar) > Perfluoroalkyl subs...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004834naa a2200445 4500
001oai:lup.lub.lu.se:dbfc380a-7a2b-47d6-a377-ab72d48faee3
003SwePub
008190521s2014 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/dbfc380a-7a2b-47d6-a377-ab72d48faee32 URI
0247 a https://doi.org/10.1186/1476-069X-13-1162 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Jørgensen, Kristian T.u Bispebjerg Hospital4 aut
2451 0a Perfluoroalkyl substances and time to pregnancy in couples from Greenland, Poland and Ukraine
264 1c 2014
520 a Background: Perfluoroalkyl substances (PFAS) are suggested to affect human fecundity through longer time to pregnancy (TTP). We studied the relationship between four abundant PFAS and TTP in pregnant women from Greenland, Poland and Ukraine representing varying PFAS exposures and pregnancy planning behaviors. Methods: We measured serum levels of perfluorooctanoic acid (PFOA), perfluorooctane sulfonate (PFOS), perfluorohexane sulfonic acid (PFHxS) and perfluorononanoic acid (PFNA) in 938 women from Greenland (448 women), Poland (203 women) and Ukraine (287 women). PFAS exposure was assessed on a continuous logarithm transformed scale and in country-specific tertiles. We used Cox discrete-time models and logistic regression to estimate fecundability ratios (FRs) and infertility (TTP >13 months) odds ratios (ORs), respectively, and 95% confidence intervals (CI) according to PFAS levels. Adjusted analyses of the association between PFAS and TTP were done for each study population and in a pooled sample. Results: Higher PFNA levels were associated with longer TTP in the pooled sample (log-scale FR∈=∈0.80; 95% CI 0.69-0.94) and specifically in women from Greenland (log-scale FR∈=∈0.72; 95% CI 0.58-0.89). ORs for infertility were also increased in the pooled sample (log-scale OR∈=∈1.53; 95% CI 1.08-2.15) and in women from Greenland (log-scale OR∈=∈1.97; 95% CI 1.22-3.19). However, in a sensitivity analysis of primiparous women these associations could not be replicated. Associations with PFNA were weaker for women from Poland and Ukraine. PFOS, PFOA and PFHxS were not consistently associated with TTP. Conclusions: Findings do not provide consistent evidence that environmental exposure to PFAS is impairing female fecundity by delaying time taken to conceive.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reproduktionsmedicin och gynekologi0 (SwePub)302202 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Obstetrics, Gynaecology and Reproductive Medicine0 (SwePub)302202 hsv//eng
653 a Fecundity
653 a Infertility
653 a Perfluorinated compounds
653 a Persistent environmental pollutants
7001 a Specht, Ina O.u Bispebjerg Hospital4 aut
7001 a Lenters, Virissau Utrecht University4 aut
7001 a Bach, Cathrine C.u Aarhus University Hospital4 aut
7001 a Rylander, Larsu Lund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine4 aut0 (Swepub:lu)ymed-lry
7001 a Jönsson, Bo A.G.u Lund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine4 aut0 (Swepub:lu)ymed-bjo
7001 a Lindh, Christian H.u Lund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine4 aut0 (Swepub:lu)ymed-cli
7001 a Giwercman, Aleksanderu Lund University,Lunds universitet,Reproduktionsmedicin, Malmö,Forskargrupper vid Lunds universitet,Reproductive medicine, Malmö,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)kir-agi
7001 a Heederik, Dicku Utrecht University4 aut
7001 a Toft, Gunnaru Aarhus University Hospital4 aut
7001 a Bonde, Jens Peteru Bispebjerg Hospital4 aut
7102 a Bispebjerg Hospitalb Utrecht University4 org
7730 t Environmental Health: A Global Access Science Sourceg 13:1q 13:1x 1476-069X
8564 u http://dx.doi.org/10.1186/1476-069X-13-116x freey FULLTEXT
8564 8u https://lup.lub.lu.se/record/dbfc380a-7a2b-47d6-a377-ab72d48faee3
8564 8u https://doi.org/10.1186/1476-069X-13-116

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