European genome-wide association study identifies SLC14A1 as a new urinary bladder cancer susceptibility gene.

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Fältnamn	Indikatorer	Metadata
000		05973naa a2201177 4500
001		oai:gup.ub.gu.se/147916
003		SwePub
008		240528s2011 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:prod.swepub.kib.ki.se:123341199
024	7	a https://gup.ub.gu.se/publication/1479162 URI
024	7	a https://doi.org/10.1093/hmg/ddr3032 DOI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1233411992 URI
040		a (SwePub)gud (SwePub)ki
041		a eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Rafnar, Thorunn4 aut
245	1 0	a European genome-wide association study identifies SLC14A1 as a new urinary bladder cancer susceptibility gene.
264		c 2011-07-12
264	1	b Oxford University Press (OUP),c 2011
520		a Three genome-wide association studies in Europe and the USA have reported eight urinary bladder cancer (UBC) susceptibility loci. Using extended case and control series and 1000 Genomes imputations of 5 340 737 single-nucleotide polymorphisms (SNPs), we searched for additional loci in the European GWAS. The discovery sample set consisted of 1631 cases and 3822 controls from the Netherlands and 603 cases and 37 781 controls from Iceland. For follow-up, we used 3790 cases and 7507 controls from 13 sample sets of European and Iranian ancestry. Based on the discovery analysis, we followed up signals in the urea transporter (UT) gene SLC14A. The strongest signal at this locus was represented by a SNP in intron 3, rs17674580, that reached genome-wide significance in the overall analysis of the discovery and follow-up groups: odds ratio = 1.17, P = 7.6 × 10(-11). SLC14A1 codes for UTs that define the Kidd blood group and are crucial for the maintenance of a constant urea concentration gradient in the renal medulla and, through this, the kidney's ability to concentrate urine. It is speculated that rs17674580, or other sequence variants in LD with it, indirectly modifies UBC risk by affecting urine production. If confirmed, this would support the 'urogenous contact hypothesis' that urine production and voiding frequency modify the risk of UBC.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
700	1	a Vermeulen, Sita H4 aut
700	1	a Sulem, Patrick4 aut
700	1	a Thorleifsson, Gudmar4 aut
700	1	a Aben, Katja K4 aut
700	1	a Witjes, J Alfred4 aut
700	1	a Grotenhuis, Anne J4 aut
700	1	a Verhaegh, Gerald W4 aut
700	1	a Hulsbergen-van de Kaa, Christina A4 aut
700	1	a Besenbacher, Soren4 aut
700	1	a Gudbjartsson, Daniel4 aut
700	1	a Stacey, Simon N4 aut
700	1	a Gudmundsson, Julius4 aut
700	1	a Johannsdottir, Hrefna4 aut
700	1	a Bjarnason, Hjordis4 aut
700	1	a Zanon, Carlo4 aut
700	1	a Helgadottir, Hafdis4 aut
700	1	a Jonasson, Jon Gunnlaugur4 aut
700	1	a Tryggvadottir, Laufey4 aut
700	1	a Jonsson, Eirikur4 aut
700	1	a Geirsson, Gudmunduru Karolinska Institutet4 aut
700	1	a Nikulasson, Sigfus4 aut
700	1	a Petursdottir, Vigdis4 aut
700	1	a Bishop, D Timothy4 aut
700	1	a Chung-Sak, Sei4 aut
700	1	a Choudhury, Ananya4 aut
700	1	a Elliott, Faye4 aut
700	1	a Barrett, Jennifer H4 aut
700	1	a Knowles, Margaret A4 aut
700	1	a de Verdier, Petra Ju Karolinska Institutet4 aut
700	1	a Ryk, Charlottau Karolinska Institutet4 aut
700	1	a Lindblom, Annikau Karolinska Institutet4 aut
700	1	a Rudnai, Peter4 aut
700	1	a Gurzau, Eugene4 aut
700	1	a Koppova, Kvetoslava4 aut
700	1	a Vineis, Paolo4 aut
700	1	a Polidoro, Silvia4 aut
700	1	a Guarrera, Simonetta4 aut
700	1	a Sacerdote, Carlotta4 aut
700	1	a Panadero, Angeles4 aut
700	1	a Sanz-Velez, José I4 aut
700	1	a Sanchez, Manuel4 aut
700	1	a Valdivia, Gabriel4 aut
700	1	a Garcia-Prats, Maria D4 aut
700	1	a Hengstler, Jan G4 aut
700	1	a Selinski, Silvia4 aut
700	1	a Gerullis, Holger4 aut
700	1	a Ovsiannikov, Daniel4 aut
700	1	a Khezri, Abdolaziz4 aut
700	1	a Aminsharifi, Alireza4 aut
700	1	a Malekzadeh, Mahyar4 aut
700	1	a van den Berg, Leonard H4 aut
700	1	a Ophoff, Roel A4 aut
700	1	a Veldink, Jan H4 aut
700	1	a Zeegers, Maurice P4 aut
700	1	a Kellen, Eliane4 aut
700	1	a Fostinelli, Jacopo4 aut
700	1	a Andreoli, Daniele4 aut
700	1	a Arici, Cecilia4 aut
700	1	a Porru, Stefano4 aut
700	1	a Buntinx, Frank4 aut
700	1	a Ghaderi, Abbas4 aut
700	1	a Golka, Klaus4 aut
700	1	a Mayordomo, José I4 aut
700	1	a Matullo, Giuseppe4 aut
700	1	a Kumar, Rajiv4 aut
700	1	a Steineck, Gunnar,d 1952u Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för onkologi,Institute of Clinical Sciences, Department of Oncology4 aut0 (Swepub:gu)xstegu
700	1	a Kiltie, Anne E4 aut
700	1	a Kong, Augustine4 aut
700	1	a Thorsteinsdottir, Unnur4 aut
700	1	a Stefansson, Kari4 aut
700	1	a Kiemeney, Lambertus A4 aut
710	2	a Karolinska Institutetb Institutionen för kliniska vetenskaper, Avdelningen för onkologi4 org
773	0	t Human molecular geneticsd : Oxford University Press (OUP)g 20:21, s. 4268-81q 20:21<4268-81x 1460-2083x 0964-6906
856	4	u https://academic.oup.com/hmg/article-pdf/20/21/4268/17252644/ddr303.pdf
856	4 8	u https://gup.ub.gu.se/publication/147916
856	4 8	u https://doi.org/10.1093/hmg/ddr303
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:123341199

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Av författaren/redakt...: Rafnar, Thorunn; Vermeulen, Sita ...; Sulem, Patrick; Thorleifsson, Gu ...; Aben, Katja K; Witjes, J Alfred; visa fler...; Grotenhuis, Anne ...; Verhaegh, Gerald ...; Hulsbergen-van d ...; Besenbacher, Sor ...; Gudbjartsson, Da ...; Stacey, Simon N; Gudmundsson, Jul ...; Johannsdottir, H ...; Bjarnason, Hjord ...; Zanon, Carlo; Helgadottir, Haf ...; Jonasson, Jon Gu ...; Tryggvadottir, L ...; Jonsson, Eirikur; Geirsson, Gudmun ...; Nikulasson, Sigf ...; Petursdottir, Vi ...; Bishop, D Timoth ...; Chung-Sak, Sei; Choudhury, Anany ...; Elliott, Faye; Barrett, Jennife ...; Knowles, Margare ...; de Verdier, Petr ...; Ryk, Charlotta; Lindblom, Annika; Rudnai, Peter; Gurzau, Eugene; Koppova, Kvetosl ...; Vineis, Paolo; Polidoro, Silvia; Guarrera, Simone ...; Sacerdote, Carlo ...; Panadero, Angele ...; Sanz-Velez, José ...; Sanchez, Manuel; Valdivia, Gabrie ...; Garcia-Prats, Ma ...; Hengstler, Jan G; Selinski, Silvia; Gerullis, Holger; Ovsiannikov, Dan ...; Khezri, Abdolazi ...; Aminsharifi, Ali ...; Malekzadeh, Mahy ...; van den Berg, Le ...; Ophoff, Roel A; Veldink, Jan H; Zeegers, Maurice ...; Kellen, Eliane; Fostinelli, Jaco ...; Andreoli, Daniel ...; Arici, Cecilia; Porru, Stefano; Buntinx, Frank; Ghaderi, Abbas; Golka, Klaus; Mayordomo, José ...; Matullo, Giusepp ...; Kumar, Rajiv; Steineck, Gunnar ...; Kiltie, Anne E; Kong, Augustine; Thorsteinsdottir ...; Stefansson, Kari; Kiemeney, Lamber ...; visa färre...

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