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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00006755naa a2200637 4500
001oai:lup.lub.lu.se:e5582dc2-3c6a-44e5-b96e-bb342d6af3d9
003SwePub
008210426s2021 | |||||||||||000 ||eng|
009oai:DiVA.org:liu-175605
009oai:DiVA.org:umu-182472
0247 a https://lup.lub.lu.se/record/e5582dc2-3c6a-44e5-b96e-bb342d6af3d92 URI
0247 a https://doi.org/10.1186/s12876-021-01737-12 DOI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1756052 URI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1824722 URI
040 a (SwePub)lud (SwePub)liud (SwePub)umu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Norström, Fredriku Umeå universitet,Umeå University,Umea Univ, Sweden,Institutionen för epidemiologi och global hälsa4 aut0 (Swepub:umu)frno0004
2451 0a Is mass screening for coeliac disease a wise use of resources? A health economic evaluation
264 c 2021-04-09
264 1b Springer Science and Business Media LLC,c 2021
500 a Funding Agencies|Umea University; Swedish Research CouncilSwedish Research CouncilEuropean Commission; Swedish Research Council for Environment, Agricultural Sciences and Spatial PlanningSwedish Research Council Formas; Swedish Council for Working Life and Social ResearchSwedish Research CouncilSwedish Research Council for Health Working Life & Welfare (Forte); Vardal Foundation; Swedish Coeliac Associations research fund
520 a Background: Living with undiagnosed symptomatic coeliac disease is connected with deteriorated health, and persons with coeliac disease often wait a long time for their diagnosis. A mass screening would lower the delay, but its cost-effectiveness is still unclear. Our aim was to determine the cost-effectiveness of a coeliac disease mass screening at 12 years of age, taking a life course perspective on future benefits and drawbacks. Methods: The cost-effectiveness was derived as cost per quality-adjusted life-year (QALY) using a Markov model. As a basis for our assumptions, we mainly used information from the Exploring the Iceberg of Celiacs in Sweden (ETICS) study, a school-based screening conducted in 2005/2006 and 2009/2010, where 13,279 12-year-old children participated and 240 were diagnosed with coeliac disease, and a study involving members of the Swedish Coeliac Association with 1031 adult participants. Results: The cost for coeliac disease screening was 40,105 Euro per gained QALY. Sensitivity analyses support screening based on high compliance to a gluten-free diet, rapid progression from symptom-free coeliac disease to coeliac disease with symptoms, long delay from celiac disease with symptoms to diagnosis, and a low QALY score for undiagnosed coeliac disease cases. Conclusions: A coeliac disease mass screening is cost-effective based on the commonly used threshold of 50,000 Euro per gained QALY. However, this is based on many assumptions, especially regarding the natural history of coeliac disease and the effects on long-term health for individuals with coeliac disease still eating gluten.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Gastroenterologi0 (SwePub)302132 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Gastroenterology and Hepatology0 (SwePub)302132 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi0 (SwePub)303022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Public Health, Global Health, Social Medicine and Epidemiology0 (SwePub)303022 hsv//eng
653 a Adolescent
653 a Coeliac disease
653 a Compliance
653 a Cost-effectiveness
653 a Long delay
653 a QALY
653 a Screening
653 a Coeliac disease; Cost-effectiveness; Compliance; Long delay; Screening; Adolescent; QALY
7001 a Myléus, Anna,c MD PhDu Umeå universitet,Umeå University,Umea Univ, Sweden,Allmänmedicin4 aut0 (Swepub:umu)anamys98
7001 a Nordyke, Katrinau Umeå universitet,Umeå University,Umea Univ, Sweden,Institutionen för epidemiologi och global hälsa4 aut0 (Swepub:umu)kaanoe03
7001 a Carlsson, Annelieu Umeå universitet,Lund University,Lunds universitet,Pediatrisk autoimmunitet,Forskargrupper vid Lunds universitet,Pediatric Autoimmunity,Lund University Research Groups,Department of Pediatrics, Clinical Sciences, Skåne University Hospital, Lund University, Lund, Sweden,Lund Univ, Sweden,Umea Univ, Sweden,Institutionen för epidemiologi och global hälsa4 aut0 (Swepub:umu)aniv0001
7001 a Högberg, Lottau Linköpings universitet,Linköping University,Vrinnevi Hospital,Avdelningen för barns och kvinnors hälsa,Medicinska fakulteten,Region Östergötland, Barn- och ungdomskliniken i Norrköping,Department of Paediatrics, Norrköping Hospital, Linköping University, Norrköping, Sweden4 aut0 (Swepub:liu)lotho28
7001 a Sandström, Olofu Umeå universitet,Umeå University,Umea Univ, Sweden; Umea Univ, Sweden,Institutionen för epidemiologi och global hälsa,Pediatrik4 aut0 (Swepub:umu)olsa0022
7001 a Stenhammar, Larsu Linköpings universitet,Linköping University,Vrinnevi Hospital,Avdelningen för barns och kvinnors hälsa,Medicinska fakulteten,Region Östergötland, Barn- och ungdomskliniken i Norrköping,Department of Paediatrics, Norrköping Hospital, Linköping University, Norrköping, Sweden4 aut0 (Swepub:liu)larst66
7001 a Ivarsson, Anneliu Umeå University4 aut
7001 a Lindholm, Larsu Umeå universitet,Umeå University,Umea Univ, Sweden,Institutionen för epidemiologi och global hälsa4 aut0 (Swepub:umu)lali0001
7102 a Umeå Universityb Umea Univ, Sweden4 org
7730 t BMC Gastroenterologyd : Springer Science and Business Media LLCg 21:1q 21:1x 1471-230X
8564 u http://dx.doi.org/10.1186/s12876-021-01737-1x freey FULLTEXT
8564 u https://bmcgastroenterol.biomedcentral.com/track/pdf/10.1186/s12876-021-01737-1
8564 u https://liu.diva-portal.org/smash/get/diva2:1553823/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 u https://doi.org/10.1186/s12876-021-01737-1y Fulltext
8564 u https://umu.diva-portal.org/smash/get/diva2:1548168/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 8u https://lup.lub.lu.se/record/e5582dc2-3c6a-44e5-b96e-bb342d6af3d9
8564 8u https://doi.org/10.1186/s12876-021-01737-1
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-175605
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-182472

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