Genome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors

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Fältnamn	Indikatorer	Metadata
000		05158naa a2201045 4500
001		oai:DiVA.org:umu-135267
003		SwePub
008		170526s2017 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1352672 URI
024	7	a https://doi.org/10.1038/ng.38232 DOI
040		a (SwePub)umu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Melin, Beatrice S.u Umeå universitet,Institutionen för strålningsvetenskaper4 aut0 (Swepub:umu)bema0010
245	1 0	a Genome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors
264		c 2017-03-27
264	1	b Springer Science and Business Media LLC,c 2017
338		a print2 rdacarrier
520		a Genome-wide association studies (GWAS) have transformed our understanding of glioma susceptibility, but individual studies have had limited power to identify risk loci. We performed a meta-analysis of existing GWAS and two new GWAS, which totaled 12,496 cases and 18,190 controls. We identified five new loci for glioblastoma (GBM) at 1p31.3 (rs12752552; P = 2.04 x 10(-9), odds ratio (OR) = 1.22), 11q14.1 (rs11233250; P = 9.95 x 10(-10), OR = 1.24), 16p13.3 (rs2562152; P = 1.93 x 10-8, OR = 1.21), 16q12.1 (rs10852606; P = 1.29 x 10(-11), OR = 1.18) and 22q13.1 (rs2235573; P = 1.76 x 10(-10), OR = 1.15), as well as eight loci for non-GBM tumors at 1q32.1 (rs4252707; P = 3.34 x 10(-9), OR = 1.19), 1q44 (rs12076373; P = 2.63 x 10(-10), OR = 1.23), 2q33.3 (rs7572263; P = 2.18 x 10(-10), OR = 1.20), 3p14.1 (rs11706832; P = 7.66 x 10(-9), OR = 1.15), 10q24.33 (rs11598018; P = 3.39 x 10-8, OR = 1.14), 11q21 (rs7107785; P = 3.87 x 10(-10), OR = 1.16), 14q12 (rs10131032; P = 5.07 x 10(-11), OR = 1.33) and 16p13.3 (rs3751667; P = 2.61 x 10(-9), OR = 1.18). These data substantiate that genetic susceptibility to GBM and non-GBM tumors are highly distinct, which likely reflects different etiology.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng
700	1	a Barnholtz-Sloan, Jill S.4 aut
700	1	a Wrensch, Margaret R.4 aut
700	1	a Johansen, Christoffer4 aut
700	1	a Il'yasova, Dora4 aut
700	1	a Kinnersley, Ben4 aut
700	1	a Ostrom, Quinn T.4 aut
700	1	a Labreche, Karim4 aut
700	1	a Chen, Yanwen4 aut
700	1	a Armstrong, Georgina4 aut
700	1	a Liu, Yanhong4 aut
700	1	a Eckel-Passow, Jeanette E.4 aut
700	1	a Decker, Paul A.4 aut
700	1	a Labussiere, Marianne4 aut
700	1	a Idbaih, Ahmed4 aut
700	1	a Hoang-Xuan, Khe4 aut
700	1	a Di Stefano, Anna-Luisa4 aut
700	1	a Mokhtari, Karima4 aut
700	1	a Delattre, Jean-Yves4 aut
700	1	a Broderick, Peter4 aut
700	1	a Galan, Pilar4 aut
700	1	a Gousias, Konstantinos4 aut
700	1	a Schramm, Johannes4 aut
700	1	a Schoemaker, Minouk J.4 aut
700	1	a Fleming, Sarah J.4 aut
700	1	a Herms, Stefan4 aut
700	1	a Heilmann, Stefanie4 aut
700	1	a Noethen, Markus M.4 aut
700	1	a Wichmann, Heinz-Erich4 aut
700	1	a Schreiber, Stefan4 aut
700	1	a Swerdlow, Anthony4 aut
700	1	a Lathrop, Mark4 aut
700	1	a Simon, Matthias4 aut
700	1	a Sanson, Marc4 aut
700	1	a Andersson, Ulrikau Umeå universitet,Institutionen för strålningsvetenskaper4 aut0 (Swepub:umu)ulan0002
700	1	a Rajaraman, Preetha4 aut
700	1	a Chanock, Stephen4 aut
700	1	a Linet, Martha4 aut
700	1	a Wang, Zhaoming4 aut
700	1	a Yeager, Meredith4 aut
700	1	a Wiencke, John K.4 aut
700	1	a Hansen, Helen4 aut
700	1	a Mccoy, Lucie4 aut
700	1	a Rice, Terri4 aut
700	1	a Kosel, Matthew L.4 aut
700	1	a Sicotte, Hugues4 aut
700	1	a Amos, Christopher I.4 aut
700	1	a Bernstein, Jonine L.4 aut
700	1	a Davis, Faith4 aut
700	1	a Lachance, Dan4 aut
700	1	a Lau, Ching4 aut
700	1	a Merrell, Ryan T.4 aut
700	1	a Shildkraut, Joellen4 aut
700	1	a Ali-Osman, Francis4 aut
700	1	a Sadetzki, Siegal4 aut
700	1	a Scheurer, Michael4 aut
700	1	a Shete, Sanjay4 aut
700	1	a Lai, Rose K.4 aut
700	1	a Claus, Elizabeth B.4 aut
700	1	a Olson, Sara H.4 aut
700	1	a Jenkins, Robert B.4 aut
700	1	a Houlston, Richard S.4 aut
700	1	a Bondy, Melissa L.4 aut
710	2	a Umeå universitetb Institutionen för strålningsvetenskaper4 org
773	0	t Nature Geneticsd : Springer Science and Business Media LLCg 49:5, s. 789-794q 49:5<789-794x 1061-4036x 1546-1718
856	4	u https://europepmc.org/articles/pmc5558246?pdf=render
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-135267
856	4 8	u https://doi.org/10.1038/ng.3823

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Av författaren/redakt...: Melin, Beatrice ...; Barnholtz-Sloan, ...; Wrensch, Margare ...; Johansen, Christ ...; Il'yasova, Dora; Kinnersley, Ben; visa fler...; Ostrom, Quinn T.; Labreche, Karim; Chen, Yanwen; Armstrong, Georg ...; Liu, Yanhong; Eckel-Passow, Je ...; Decker, Paul A.; Labussiere, Mari ...; Idbaih, Ahmed; Hoang-Xuan, Khe; Di Stefano, Anna ...; Mokhtari, Karima; Delattre, Jean-Y ...; Broderick, Peter; Galan, Pilar; Gousias, Konstan ...; Schramm, Johanne ...; Schoemaker, Mino ...; Fleming, Sarah J ...; Herms, Stefan; Heilmann, Stefan ...; Noethen, Markus ...; Wichmann, Heinz- ...; Schreiber, Stefa ...; Swerdlow, Anthon ...; Lathrop, Mark; Simon, Matthias; Sanson, Marc; Andersson, Ulrik ...; Rajaraman, Preet ...; Chanock, Stephen; Linet, Martha; Wang, Zhaoming; Yeager, Meredith; Wiencke, John K.; Hansen, Helen; Mccoy, Lucie; Rice, Terri; Kosel, Matthew L ...; Sicotte, Hugues; Amos, Christophe ...; Bernstein, Jonin ...; Davis, Faith; Lachance, Dan; Lau, Ching; Merrell, Ryan T.; Shildkraut, Joel ...; Ali-Osman, Franc ...; Sadetzki, Siegal; Scheurer, Michae ...; Shete, Sanjay; Lai, Rose K.; Claus, Elizabeth ...; Olson, Sara H.; Jenkins, Robert ...; Houlston, Richar ...; Bondy, Melissa L ...; visa färre...

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