Renal dysfunction is associated with shorter telomere length in heart failure.

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Fältnamn	Indikatorer	Metadata
000		02987naa a2200397 4500
001		oai:DiVA.org:liu-62416
003		SwePub
008		101130s2009 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-624162 URI
024	7	a https://doi.org/10.1007/s00392-009-0048-72 DOI
040		a (SwePub)liu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Wong, Liza S M4 aut
245	1 0	a Renal dysfunction is associated with shorter telomere length in heart failure.
264		c 2009-07-15
264	1	b Springer Science and Business Media LLC,c 2009
338		a print2 rdacarrier
520		a BACKGROUND: Renal dysfunction is a frequent comorbidity associated with high mortality in patients with chronic heart failure (CHF). The intrinsic biological age might affect the ability of the kidney to cope with the challenging environment caused by CHF. We explored the association between leukocyte telomere length, a marker for biological age, and renal function in patients with CHF. METHODS AND RESULTS: Telomere length was determined by a real-time quantitative polymerase chain reaction in 866 CHF patients. Renal function was estimated with the simplified Modification of Diet in Renal Disease equation. The median age was 74 (interquartile range 64-79) years, 61% male, left ventricular ejection fraction of 30 (23-44)%, and the estimated glomerular filtration rate was 53 (40-68) ml/min/1.73 m(2). Telomere length was associated with renal function (correlation coefficient 0.123, P < 0.001). This relationship remained significant after adjustment for age, gender, age of CHF onset (standardized-beta 0.091, P = 0.007). Also additionally adjusting for the severity of CHF and baseline differences did not change our findings. CONCLUSION: The association between shorter leukocyte telomere length and reduced renal function in heart failure suggests that intrinsic biological aging affects the ability of the kidney to cope with the systemic changes evoked by heart failure.
700	1	a van der Harst, Pim4 aut
700	1	a de Boer, Rudolf A4 aut
700	1	a Codd, Veryan4 aut
700	1	a Huzen, Jardi4 aut
700	1	a Samani, Nilesh J4 aut
700	1	a Hillege, Hans L4 aut
700	1	a Voors, Adriaan A4 aut
700	1	a van Gilst, Wiek H4 aut
700	1	a Jaarsma, Tiny4 aut
700	1	a van Veldhuisen, Dirk J4 aut
773	0	t Clinical research in cardiology : official journal of the German Cardiac Societyd : Springer Science and Business Media LLCg 98:10, s. 629-34q 98:10<629-34x 1861-0692
773	0	t Clinical Research in Cardiologyd : Springer Science and Business Media LLCg 98:10, s. 629-34q 98:10<629-34x 1861-0684
856	4	u https://europepmc.org/articles/pmc2752505?pdf=render
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-62416
856	4 8	u https://doi.org/10.1007/s00392-009-0048-7

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Av författaren/redakt...: Wong, Liza S M; van der Harst, P ...; de Boer, Rudolf ...; Codd, Veryan; Huzen, Jardi; Samani, Nilesh J; visa fler...; Hillege, Hans L; Voors, Adriaan A; van Gilst, Wiek ...; Jaarsma, Tiny; van Veldhuisen, ...; visa färre...

Artiklar i publikationen: Clinical researc ...; Clinical Researc ...

Av lärosätet: Linköpings universitet

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