Sökning: WFRF:(Vilá Luis M) > A large-scale repli...
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000 | 08549naa a2200961 4500 | |
001 | oai:DiVA.org:uu-117767 | |
003 | SwePub | |
008 | 100222s2009 | |||||||||||000 ||eng| | |
009 | oai:DiVA.org:umu-31020 | |
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024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1177672 URI |
024 | 7 | a https://doi.org/10.1038/ng.4682 DOI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-310202 URI |
024 | 7 | a https://lup.lub.lu.se/record/15049522 URI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1195536082 URI |
040 | a (SwePub)uud (SwePub)umud (SwePub)lud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Gateva, Veselau Immunology Biomarkers Group, Genentech, South San Francisco, California, USA4 aut |
245 | 1 0 | a A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus |
264 | c 2009-10-18 | |
264 | 1 | b Springer Science and Business Media LLC,c 2009 |
338 | a print2 rdacarrier | |
500 | a De två första författarna delar förstaförfattarskapet | |
520 | a Genome-wide association studies have recently identified at least 15 susceptibility loci for systemic lupus erythematosus (SLE). To confirm additional risk loci, we selected SNPs from 2,466 regions that showed nominal evidence of association to SLE (P < 0.05) in a genome-wide study and genotyped them in an independent sample of 1,963 cases and 4,329 controls. This replication effort identified five new SLE susceptibility loci (P < 5 x 10(-8)): TNIP1 (odds ratio (OR) = 1.27), PRDM1 (OR = 1.20), JAZF1 (OR = 1.20), UHRF1BP1 (OR = 1.17) and IL10 (OR = 1.19). We identified 21 additional candidate loci with P< or = 1 x 10(-5). A candidate screen of alleles previously associated with other autoimmune diseases suggested five loci (P < 1 x 10(-3)) that may contribute to SLE: IFIH1, CFB, CLEC16A, IL12B and SH2B3. These results expand the number of confirmed and candidate SLE susceptibility loci and implicate several key immunologic pathways in SLE pathogenesis. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reumatologi och inflammation0 (SwePub)302102 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Rheumatology and Autoimmunity0 (SwePub)302102 hsv//eng |
653 | a type I IFN system | |
653 | a autoimmunity | |
653 | a lupus | |
653 | a SLE | |
653 | a risk genes | |
653 | a MEDICINE | |
653 | a MEDICIN | |
653 | a Medicin | |
653 | a Medicine | |
700 | 1 | a Sandling, Johanna K.u Uppsala universitet,Molekylär medicin,Molecular Medicine, Department of Medical Sciences, Uppsala University, Uppsala, Sweden4 aut0 (Swepub:uu)josan062 |
700 | 1 | a Hom, Geoffu Immunology Biomarkers Group, Genentech, South San Francisco, California, USA4 aut |
700 | 1 | a Taylor, Kimberly E.u Rosalind Russell Medical Research Center for Arthritis, Department of Medicine, University of California, San Francisco, California, USA4 aut |
700 | 1 | a Chung, Sharon A.u Rosalind Russell Medical Research Center for Arthritis, Department of Medicine, University of California, San Francisco, California, USA4 aut |
700 | 1 | a Sun, Xinu Immunology Biomarkers Group, Genentech, South San Francisco, California, USA4 aut |
700 | 1 | a Ortmann, Wardu Immunology Biomarkers Group, Genentech, South San Francisco, California, USA4 aut |
700 | 1 | a Kosoy, Romanu Rowe Program in Genetics, University of California at Davis, Davis, California, USA4 aut |
700 | 1 | a Ferreira, Ricardo C.u Immunology Biomarkers Group, Genentech, South San Francisco, California, USA4 aut |
700 | 1 | a Nordmark, Gunnelu Uppsala universitet,Institutionen för medicinska vetenskaper,Rheumatology, Systemic Autoimmmune Diseases,Section of Rheumatology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden4 aut0 (Swepub:uu)gunnnord |
700 | 1 | a Gunnarsson, Ivau Karolinska Institutet4 aut |
700 | 1 | a Svenungsson, Elisabetu Karolinska Institutet4 aut |
700 | 1 | a Padyukov, Leonidu Karolinska Institutet4 aut |
700 | 1 | a Sturfelt, Gunnaru Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)reum-gst |
700 | 1 | a Jönsen, Andreasu Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)reum-ajo |
700 | 1 | a Bengtsson, Andersu Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)reum-abe |
700 | 1 | a Rantapää-Dahlqvist, Solbrittu Umeå universitet,Reumatologi4 aut0 (Swepub:umu)sora0001 |
700 | 1 | a Baechler, Emily C.u Center for Immunology, University of Minnesota Medical School, Minneapolis, Minnesota, USA4 aut |
700 | 1 | a Brown, Elizabeth E.u University of Alabama at Birmingham, Birmingham, Alabama, USA4 aut |
700 | 1 | a Alarcón, Graciela S.u University of Alabama at Birmingham, Birmingham, Alabama, USA4 aut |
700 | 1 | a Edberg, Jeffrey C.u University of Alabama at Birmingham, Birmingham, Alabama, USA4 aut |
700 | 1 | a Ramsey-Goldman, Rosalindu Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA4 aut |
700 | 1 | a McGwin, Geraldu University of Alabama at Birmingham, Birmingham, Alabama, USA4 aut |
700 | 1 | a Reveille, John D.u University of Texas–Houston Health Science Center, Houston, Texas, USA4 aut |
700 | 1 | a Vilá, Luis M.u University of Puerto Rico Medical Science Campus, San Juan, Puerto Rico4 aut |
700 | 1 | a Kimberly, Robert P.u University of Alabama at Birmingham, Birmingham, Alabama, USA4 aut |
700 | 1 | a Manzi, Susanu University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA4 aut |
700 | 1 | a Petri, Michelle A.u Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA4 aut |
700 | 1 | a Lee, Annetteu The Feinstein Institute for Medical Research, North Shore–Long Island Jewish Health System, Manhasset, New York, USA4 aut |
700 | 1 | a Gregersen, Peter K.u The Feinstein Institute for Medical Research, North Shore–Long Island Jewish Health System, Manhasset, New York, USA4 aut |
700 | 1 | a Seldin, Michael F.u Rowe Program in Genetics, University of California at Davis, Davis, California, USA4 aut |
700 | 1 | a Rönnblom, Larsu Uppsala universitet,Institutionen för medicinska vetenskaper,Rheumatology, Systemic Autoimmmune Diseases,Section of Rheumatology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden4 aut0 (Swepub:uu)larsronn |
700 | 1 | a Criswell, Lindsey A.u Rosalind Russell Medical Research Center for Arthritis, Department of Medicine, University of California, San Francisco, California, USA4 aut |
700 | 1 | a Syvänen, Ann-Christineu Uppsala universitet,Molekylär medicin,Molecular Medicine, Department of Medical Sciences, Uppsala University, Uppsala, Sweden4 aut0 (Swepub:uu)anncsyva |
700 | 1 | a Behrens, Timothy W.u Immunology Biomarkers Group, Genentech, South San Francisco, California, USA4 aut |
700 | 1 | a Graham, Robert R.u Immunology Biomarkers Group, Genentech, South San Francisco, California, USA4 aut |
710 | 2 | a Immunology Biomarkers Group, Genentech, South San Francisco, California, USAb Molekylär medicin4 org |
773 | 0 | t Nature Geneticsd : Springer Science and Business Media LLCg 41:11, s. 1228-1233q 41:11<1228-1233x 1061-4036x 1546-1718 |
856 | 4 | u https://europepmc.org/articles/pmc2925843?pdf=render |
856 | 4 | u http://dx.doi.org/10.1038/ng.468y FULLTEXT |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-117767 |
856 | 4 8 | u https://doi.org/10.1038/ng.468 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-31020 |
856 | 4 8 | u https://lup.lub.lu.se/record/1504952 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:119553608 |
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