L773:0890 9369
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 01964naa a2200313 4500 | |
| 001 | oai:prod.swepub.kib.ki.se:1943669 | |
| 003 | SwePub | |
| 008 | 240913s1998 | |||||||||||000 ||eng| | |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:19436692 URI |
| 024 | 7 | a https://doi.org/10.1101/gad.12.20.32172 DOI |
| 040 | a (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Davies, RC4 aut |
| 245 | 1 0 | a WT1 interacts with the splicing factor U2AF65 in an isoform-dependent manner and can be incorporated into spliceosomes |
| 264 | c 1998-10-15 | |
| 264 | 1 | b Cold Spring Harbor Laboratory,c 1998 |
| 520 | a WT1 is essential for normal kidney development, and genetic alterations are associated with Wilms’ tumor, Denys Drash (DDS), and Frasier syndromes. Although generally considered a transcription factor this study has revealed that WT1 interacts with an essential splicing factor, U2AF65, and associates with the splicing machinery. WT1 is alternatively spliced and isoforms that include three amino acids, KTS, show stronger interaction with U2AF65 in vitro and better colocalization with splicing factors in vivo. Interestingly a mutation associated with DDS enhanced both −KTS WT1 binding to U2AF65 and splicing-factor colocalization. These data illustrate the functional importance of WT1 isoforms and suggest that WT1 plays a role in pre-mRNA splicing. | |
| 700 | 1 | a Calvio, C4 aut |
| 700 | 1 | a Bratt, E4 aut |
| 700 | 1 | a Larsson, SH4 aut |
| 700 | 1 | a Lamond, AI4 aut |
| 700 | 1 | a Hastie, ND4 aut |
| 773 | 0 | t Genes & developmentd : Cold Spring Harbor Laboratoryg 12:20, s. 3217-3225q 12:20<3217-3225x 0890-9369x 1549-5477 |
| 856 | 4 | u http://genesdev.cshlp.org/content/12/20/3217.full.pdf |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:1943669 |
| 856 | 4 8 | u https://doi.org/10.1101/gad.12.20.3217 |
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