L773:0952 3278 OR L773:1532 2823
Search: L773:0952 3278 OR L773:1532 2823 > Allergen-induced fo...
- 18 of 65
- Previous record
- Next record
- To hitlist
Allergen-induced formation of F2-isoprostanes in a murine asthma model identifies oxidative stress in acute airway inflammation in vivo
-
- Jonasson, Sofia (author)
- Uppsala universitet,Klinisk fysiologi
-
- Hjoberg, Josephine (author)
- Uppsala universitet,Klinisk fysiologi
-
- Hedenstierna, Göran (author)
- Uppsala universitet,Klinisk fysiologi
- show more...
- show less...
- (creator_code:org_t)
- Elsevier BV, 2009
- 2009
- English.
- In: Prostaglandins, Leukotrienes and Essential Fatty Acids. - : Elsevier BV. - 0952-3278 .- 1532-2823. ; 80:1, s. 1-7
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- F2-isoprostanes have been associated with various forms of oxidant stress. The levels of F2-isoprostanes in a murine asthma model were studied both in situ and in vivo and further investigated whether the formation of F2-isoprostanes was associated with increased ovalbumin (OVA)-induced airway inflammation after a 17-day (OVA-17) or a 24-day (OVA-24) protocol. Bronchial reactivity was assessed by using a ventilator (FlexiVent). OVA-treated animals had higher lung resistance and lung compliance compared to control groups (P<0.001). 8-Iso-PGF2α levels in bronchoalveolar lavage (BAL) and 8-iso-PGF2α immunoreactivity in lung tissue were analyzed. OVA-17 mice showed a 2.5-fold increased level of 8-iso-PGF2α in BAL compared to PBS-17 mice (P=0.023). Lung tissue from OVA-24 mice had more intense 8-iso-PGF2α staining compared to OVA-17 mice. This study showed an accumulation of F2-isoprostanes in acute airway inflammation and a markedly increased tissue damage caused by oxidative stress in an ongoing inflammation.
Keyword
- Isoprostanes
- Animal model
- Asthma
- Oxidative stress
- Lung mechanics
- Airway inflammation
- In situ
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
- Prostaglandins, Leukotrienes and Essential Fatty Acids (Search for host publication in LIBRIS)
To the university's database
- 18 of 65
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Jonasson, Sofia
- Hjoberg, Josephi ...
- Hedenstierna, Gö ...
- Basu, Samar
- Articles in the publication
- Prostaglandins, ...
- By the university
- Uppsala University
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
