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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 02798naa a2200409 4500 | |
| 001 | oai:DiVA.org:uu-99318 | |
| 003 | SwePub | |
| 008 | 090311s2009 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-993182 URI |
| 024 | 7 | a https://doi.org/10.1016/j.plefa.2008.10.0012 DOI |
| 040 | a (SwePub)uu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Jonasson, Sofiau Uppsala universitet,Klinisk fysiologi4 aut0 (Swepub:uu)sojon516 |
| 245 | 1 0 | a Allergen-induced formation of F2-isoprostanes in a murine asthma model identifies oxidative stress in acute airway inflammation in vivo |
| 264 | 1 | b Elsevier BV,c 2009 |
| 338 | a print2 rdacarrier | |
| 520 | a F2-isoprostanes have been associated with various forms of oxidant stress. The levels of F2-isoprostanes in a murine asthma model were studied both in situ and in vivo and further investigated whether the formation of F2-isoprostanes was associated with increased ovalbumin (OVA)-induced airway inflammation after a 17-day (OVA-17) or a 24-day (OVA-24) protocol. Bronchial reactivity was assessed by using a ventilator (FlexiVent). OVA-treated animals had higher lung resistance and lung compliance compared to control groups (P<0.001). 8-Iso-PGF2α levels in bronchoalveolar lavage (BAL) and 8-iso-PGF2α immunoreactivity in lung tissue were analyzed. OVA-17 mice showed a 2.5-fold increased level of 8-iso-PGF2α in BAL compared to PBS-17 mice (P=0.023). Lung tissue from OVA-24 mice had more intense 8-iso-PGF2α staining compared to OVA-17 mice. This study showed an accumulation of F2-isoprostanes in acute airway inflammation and a markedly increased tissue damage caused by oxidative stress in an ongoing inflammation. | |
| 653 | a Isoprostanes | |
| 653 | a Animal model | |
| 653 | a Asthma | |
| 653 | a Oxidative stress | |
| 653 | a Lung mechanics | |
| 653 | a Airway inflammation | |
| 653 | a In situ | |
| 653 | a MEDICINE | |
| 653 | a MEDICIN | |
| 700 | 1 | a Hjoberg, Josephineu Uppsala universitet,Klinisk fysiologi4 aut0 (Swepub:uu)josehjob |
| 700 | 1 | a Hedenstierna, Göranu Uppsala universitet,Klinisk fysiologi4 aut0 (Swepub:uu)goranhed |
| 700 | 1 | a Basu, Samaru Uppsala universitet,Oxidativ stress och inflammation4 aut0 (Swepub:uu)samabasu |
| 710 | 2 | a Uppsala universitetb Klinisk fysiologi4 org |
| 773 | 0 | t Prostaglandins, Leukotrienes and Essential Fatty Acidsd : Elsevier BVg 80:1, s. 1-7q 80:1<1-7x 0952-3278x 1532-2823 |
| 856 | 4 | u http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19081714 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-99318 |
| 856 | 4 8 | u https://doi.org/10.1016/j.plefa.2008.10.001 |
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