Hypoxia gradually augments metabolic and thermoperceptual responsiveness to repeated whole-body cold stress in humans

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Fältnamn	Indikatorer	Metadata
000		02869naa a2200313 4500
001		oai:DiVA.org:kth-284590
003		SwePub
008		201030s2020 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-2845902 URI
024	7	a https://doi.org/10.1113/EP0890702 DOI
040		a (SwePub)kth
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Keramidas, Michail E.,c Assistant Professoru KTH,Omgivningsfysiologi4 aut0 (Swepub:kth)u1uu7lyn
245	1 0	a Hypoxia gradually augments metabolic and thermoperceptual responsiveness to repeated whole-body cold stress in humans
264	1	c 2020
338		a electronic2 rdacarrier
500		a QC 20201130
520		a We examined whether hypoxia would modulate thermoeffector responses during repeated cold stress encountered in a single day. Eleven men completed two ∼10 h sessions, while breathing, in normobaria, either normoxia or hypoxia (PO2 : 12 kPa). During each session, subjects underwent sequentially three 120 min immersions to the chest in 20◦C water (CWI), interspersed by 120 min rewarming. In normoxia, the final drop in rectal temperature (Trec) was greater in the third (∼1.2◦C) than in the first and second (∼0.9◦C) CWIs (P < 0.05). The first hypoxic CWI augmented the Trec fall (∼1.2◦C; P = 0.002), but the drop in Trec did not vary between the three hypoxic CWIs (P = 0.99). In normoxia, the metabolic heat production (Ṁ ) was greater during the first half of the third CWI than during the corresponding part of the first CWI (P = 0.02); yet the difference was blunted during the second half of the CWIs (P = 0.89). In hypoxia, by contrast, the increase in Ṁ was augmented by ∼25% throughout the third CWI (P < 0.01). Regardless of the breathing condition, the cold-induced elevation in mean arterial pressure was blunted in the second and third CWI (P < 0.05). Hypoxia aggravated the sensation of coldness (P = 0.05) and thermal discomfort (P = 0.04) during the second half of the third CWI. The present findings therefore demonstrate that prolonged hypoxia mediates, in a gradual manner, metabolic and thermoperceptual sensitization to repeated cold stress.
700	1	a Kölegård, Rogeru KTH,Omgivningsfysiologi4 aut0 (Swepub:kth)u1nydatc
700	1	a Eiken, Olau KTH,Omgivningsfysiologi4 aut0 (Swepub:kth)u1fcwvxl
710	2	a KTHb Omgivningsfysiologi4 org
773	0	t Experimental Physiologyg 105, s. 2123-2140q 105<2123-2140x 0958-0670x 1469-445X
856	4	u https://doi.org/10.1113/EP089070y Fulltext
856	4	u https://kth.diva-portal.org/smash/get/diva2:1484825/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-284590
856	4 8	u https://doi.org/10.1113/EP089070

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