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Novel strategies to...
Novel strategies to identify biomarkers in tuberculosis
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- Jacobsen, Marc (författare)
- Max Planck Institute for Infection Biology, Department of Immunology, Berlin, Germany
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- Mattow, Jens (författare)
- Max Planck Institute for Infection Biology, Department of Immunology, Berlin, Germany; Department of Immunology, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany
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- Repsilber, Dirk, 1971- (författare)
- Research Institute for the Biology of Farm Animals, Genetics and Biometry, Dummerstorf, Germany
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- Kaufmann, Stefan H E (författare)
- Max Planck Institute for Infection Biology, Department of Immunology, Berlin, Germany
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(creator_code:org_t)
- Berlin, Germany : Walter de Gruyter, 2008
- 2008
- Engelska.
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Ingår i: Biological chemistry (Print). - Berlin, Germany : Walter de Gruyter. - 1431-6730 .- 1437-4315. ; 389:5, s. 487-95
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The more we learn about the immune response against tuberculosis (TB) and particularly about the features which distinguish protective immunity, disease susceptibility and pathology, the better we can define biomarkers which correlate with these different stages of infection. The most widely used biomarker in TB, which without a doubt is an important component of protective immunity, is IFNgamma secreted by antigen-specific CD4 T-cells. However, the complexity of the immune response against TB makes it more than likely that additional biomarkers are required for a reliable correlate of protection. As a corollary, we assume that a set of biomarkers will be required, termed a biosignature.
Ämnesord
- NATURVETENSKAP -- Biologi -- Bioinformatik och systembiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Bioinformatics and Systems Biology (hsv//eng)
Nyckelord
- Antigen
- biosignature
- metabolomics
- proteomics
- T-cells
- transcriptomics
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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