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Biological dermal t...
Biological dermal templates with native collagen scaffolds provide guiding ridges for invading cells and may promote structured dermal wound healing
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- Dill, Veronika (författare)
- Lund University
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- Mörgelin, Matthias (författare)
- Lund University,Lunds universitet,Infektionsmedicin,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Infection Medicine (BMC),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Colzyx AB
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(creator_code:org_t)
- 2020-02-11
- 2020
- Engelska 13 s.
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Ingår i: International Wound Journal. - : Wiley. - 1742-4801 .- 1742-481X. ; 17:3, s. 618-630
- Relaterad länk:
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http://dx.doi.org/10...
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https://onlinelibrar...
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Abstract
Ämnesord
Stäng
- Dermal substitutes are of major importance in treating full thickness skin defects. They come in a variety of materials manufactured into various forms, such as films, hydrocolloids, hydrogels, sponges, membranes, and electrospun micro- and nanofibers. Bioactive dermal substitutes act in wound healing either by delivery of bioactive compounds or by being constructed from materials having endogenous activity. The healing success rate is highly determined by cellular and physiological processes at the host-biomaterial interface during crucial wound healing steps. Hence, it is important to design appropriate wound treatment strategies with the ability to work actively with tissues and cells to enhance healing. Therefore, in this study, we investigated biological dermal templates and their potential to stimulate natural cell adherence, guidance, and morphology. The most pronounced effect was observed in biomaterials with the highest content of native collagen networks. Cell attachment and proliferation were significantly enhanced on native collagen scaffolds. Cell morphology was more asymmetrical on such scaffolds, resembling native in vivo structures. Importantly, considerably lower expression of myofibroblast phenotype was observed on native collagen scaffolds. Our data suggest that this treatment strategy might be beneficial for the wound environment, with the potential to promote improved tissue regeneration and reduce abnormal scar formation.
Ämnesord
- TEKNIK OCH TEKNOLOGIER -- Medicinteknik -- Medicinsk material- och protesteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Medical Engineering -- Medical Materials (hsv//eng)
Nyckelord
- bioactive dermal template
- cell adherence
- cell proliferation
- native collagen scaffold
- structured healing
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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