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Prenatal mercury exposure, maternal seafood consumption and associations with child language at five years

Vejrup, Kristine (författare)
Norwegian Institute of Public Health
Brandlistuen, Ragnhild Eek (författare)
Norwegian Institute of Public Health
Brantsæter, Anne Lise (författare)
Norwegian Institute of Public Health
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Knutsen, Helle Katrine (författare)
Norwegian Institute of Public Health
Caspersen, Ida Henriette (författare)
Norwegian Institute of Public Health
Alexander, Jan (författare)
Norwegian Institute of Public Health
Lundh, Thomas (författare)
Lund University,Lunds universitet,Genetisk arbets- och miljömedicin,Forskargrupper vid Lunds universitet,Genetic Occupational and Environmental Medicine,Lund University Research Groups
Meltzer, Helle Margrete (författare)
Norwegian Institute of Public Health
Magnus, Per (författare)
Norwegian Institute of Public Health
Haugen, Margaretha (författare)
Norwegian Institute of Public Health
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 (creator_code:org_t)
Elsevier BV, 2018
2018
Engelska.
Ingår i: Environment International. - : Elsevier BV. - 0160-4120. ; 110, s. 71-79
Relaterad länk:
http://dx.doi.org/10...
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https://lup.lub.lu.s...
https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Background: Methyl mercury (MeHg) is a well-known neurotoxin and evidence suggests that also low level exposure may affect prenatal neurodevelopment. Uncertainty exists as to whether the maternal MeHg burden in Norway might affect child neurodevelopment. Objective: To evaluate the association between prenatal mercury exposure, maternal seafood consumption and child language and communication skills at age five. Methods: The study sample comprised 38,581 mother-child pairs in the Norwegian Mother and Child Cohort Study. Maternal mercury blood concentration in gestational week 17 was analysed in a sub-sample of 2239 women. Prenatal mercury exposure from maternal diet was calculated from a validated FFQ answered in mid-pregnancy. Mothers reported children's language and communications skills at age five by a questionnaire including questions from the Ages and Stages Questionnaire (ASQ), the Speech and Language Assessment Scale (SLAS) and the Twenty Statements about Language-Related Difficulties (language 20). We performed linear regression analyses adjusting for maternal characteristics, nutritional status and socioeconomic factors. Results: Median maternal blood mercury concentration was 1.03. μg/L, dietary mercury exposure was 0.15. μg/kg. bw/wk, and seafood intake was 217. g/wk. Blood mercury concentrations were not associated with any language and communication scales. Increased dietary mercury exposure was significantly associated with improved SLAS scores when mothers had a seafood intake below 400. g/wk in the adjusted analysis. Sibling matched analysis showed a small significant adverse association between those above the 90th percentile dietary mercury exposure and the SLAS scores. Maternal seafood intake during pregnancy was positively associated with the language and communication scales. Conclusion: Low levels of prenatal mercury exposure were positively associated with language and communication skills at five years. However, the matched sibling analyses suggested an adverse association between mercury and child language skills in the highest exposure group. This indicates that prenatal low level mercury exposure still needs our attention.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)

Nyckelord

Diet
Fish and seafood intake
Language development
Maternal blood levels
Methylmercury
The Norwegian mother and child cohort study

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art (ämneskategori)
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