Sökning: WFRF:(Krauss H.) > Meta-analysis of ge...
Fältnamn | Indikatorer | Metadata |
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000 | 06310naa a2201489 4500 | |
001 | oai:gup.ub.gu.se/250698 | |
003 | SwePub | |
008 | 240910s2016 | |||||||||||000 ||eng| | |
024 | 7 | a https://gup.ub.gu.se/publication/2506982 URI |
024 | 7 | a https://doi.org/10.1136/jmedgenet-2016-1039662 DOI |
040 | a (SwePub)gu | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Postmus, I.4 aut |
245 | 1 0 | a Meta-analysis of genome-wide association studies of HDL cholesterol response to statins |
264 | c 2016-09-01 | |
264 | 1 | b BMJ,c 2016 |
520 | a Background In addition to lowering low density lipoprotein cholesterol (LDL-C), statin therapy also raises high density lipoprotein cholesterol (HDL-C) levels. Interindividual variation in HDL-C response to statins may be partially explained by genetic variation. Methods and results We performed a meta-analysis of genome-wide association studies (GWAS) to identify variants with an effect on statin-induced high density lipoprotein cholesterol (HDL-C) changes. The 123 most promising signals with p<1x10(-4) from the 16 769 statin-treated participants in the first analysis stage were followed up in an independent group of 10 951 statin-treated individuals, providing a total sample size of 27 720 individuals. The only associations of genome-wide significance (p<5x10(-8)) were between minor alleles at the CETP locus and greater HDL-C response to statin treatment. Conclusions Based on results from this study that included a relatively large sample size, we suggest that CETP may be the only detectable locus with common genetic variants that influence HDL-C response to statins substantially in individuals of European descent. Although CETP is known to be associated with HDL-C, we provide evidence that this pharmacogenetic effect is independent of its association with baseline HDL-C levels. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng |
653 | a density-lipoprotein cholesterol | |
653 | a transfer protein gene | |
653 | a coronary | |
653 | a atherosclerosis | |
653 | a cardiovascular events | |
653 | a lowering response | |
653 | a ldl | |
653 | a cholesterol | |
653 | a atorvastatin | |
653 | a disease | |
653 | a risk | |
653 | a lipids | |
653 | a Genetics & Heredity | |
700 | 1 | a Warren, H. R.4 aut |
700 | 1 | a Trompet, S.4 aut |
700 | 1 | a Arsenault, B. J.4 aut |
700 | 1 | a Avery, C. L.4 aut |
700 | 1 | a Bis, J. C.4 aut |
700 | 1 | a Chasman, D. I.4 aut |
700 | 1 | a de Keyser, C. E.4 aut |
700 | 1 | a Deshmukh, H. A.4 aut |
700 | 1 | a Evans, D. S.4 aut |
700 | 1 | a Feng, Q. P.4 aut |
700 | 1 | a Li, X. H.4 aut |
700 | 1 | a Smit, R. A. J.4 aut |
700 | 1 | a Smith, A. V.4 aut |
700 | 1 | a Sun, F. G.4 aut |
700 | 1 | a Taylor, K. D.4 aut |
700 | 1 | a Arnold, A. M.4 aut |
700 | 1 | a Barnes, M. R.4 aut |
700 | 1 | a Barratt, B. J.4 aut |
700 | 1 | a Betteridge, J.4 aut |
700 | 1 | a Boekholdt, S. M.4 aut |
700 | 1 | a Boerwinkle, E.4 aut |
700 | 1 | a Buckley, B. M.4 aut |
700 | 1 | a Chen, Y. D. I.4 aut |
700 | 1 | a de Craen, A. J. M.4 aut |
700 | 1 | a Cummings, S. R.4 aut |
700 | 1 | a Denny, J. C.4 aut |
700 | 1 | a Dube, M. P.4 aut |
700 | 1 | a Durrington, P. N.4 aut |
700 | 1 | a Eiriksdottir, G.4 aut |
700 | 1 | a Ford, I.4 aut |
700 | 1 | a Guo, X. Q.4 aut |
700 | 1 | a Harris, T. B.4 aut |
700 | 1 | a Heckbert, S. R.4 aut |
700 | 1 | a Hofman, A.4 aut |
700 | 1 | a Hovingh, G. K.4 aut |
700 | 1 | a Kastelein, J. J. P.4 aut |
700 | 1 | a Launer, L. J.4 aut |
700 | 1 | a Liu, C. T.4 aut |
700 | 1 | a Liu, Y. M.4 aut |
700 | 1 | a Lumley, T.4 aut |
700 | 1 | a McKeigue, P. M.4 aut |
700 | 1 | a Munroe, P. B.4 aut |
700 | 1 | a Neil, A.4 aut |
700 | 1 | a Nickerson, D. A.4 aut |
700 | 1 | a Nyberg, Fredrik,d 1961u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa, enheten för arbets-och miljömedicin,Institute of Medicine, Department of Public Health and Community Medicine, Section of Occupational and environmental medicine4 aut0 (Swepub:gu)xnybef |
700 | 1 | a O'Brien, E.4 aut |
700 | 1 | a O'Donnell, C. J.4 aut |
700 | 1 | a Post, W.4 aut |
700 | 1 | a Poulter, N.4 aut |
700 | 1 | a Vasan, R. S.4 aut |
700 | 1 | a Rice, K.4 aut |
700 | 1 | a Rich, S. S.4 aut |
700 | 1 | a Rivadeneira, F.4 aut |
700 | 1 | a Sattar, N.4 aut |
700 | 1 | a Sever, P.4 aut |
700 | 1 | a Shaw-Hawkins, S.4 aut |
700 | 1 | a Shields, D. C.4 aut |
700 | 1 | a Slagboom, P. E.4 aut |
700 | 1 | a Smith, N. L.4 aut |
700 | 1 | a Smith, J. D.4 aut |
700 | 1 | a Sotoodehnia, N.4 aut |
700 | 1 | a Stanton, A.4 aut |
700 | 1 | a Stott, D. J.4 aut |
700 | 1 | a Stricker, B. H.4 aut |
700 | 1 | a Sturmer, T.4 aut |
700 | 1 | a Uitterlinden, A. G.4 aut |
700 | 1 | a Wei, W. Q.4 aut |
700 | 1 | a Westendorp, R. G. J.4 aut |
700 | 1 | a Whitsel, E. A.4 aut |
700 | 1 | a Wiggins, K. L.4 aut |
700 | 1 | a Wilke, R. A.4 aut |
700 | 1 | a Ballantyne, C. M.4 aut |
700 | 1 | a Colhoun, H. M.4 aut |
700 | 1 | a Cupples, L. A.4 aut |
700 | 1 | a Franco, O. H.4 aut |
700 | 1 | a Gudnason, V.4 aut |
700 | 1 | a Hitman, G.4 aut |
700 | 1 | a Palmer, C. N. A.4 aut |
700 | 1 | a Psaty, B. M.4 aut |
700 | 1 | a Ridker, P. M.4 aut |
700 | 1 | a Stafford, J. M.4 aut |
700 | 1 | a Stein, C. M.4 aut |
700 | 1 | a Tardif, J. C.4 aut |
700 | 1 | a Caulfield, M. J.4 aut |
700 | 1 | a Jukema, J. W.4 aut |
700 | 1 | a Rotter, J. I.4 aut |
700 | 1 | a Krauss, R. M.4 aut |
710 | 2 | a Göteborgs universitetb Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa, enheten för arbets-och miljömedicin4 org |
773 | 0 | t Journal of Medical Geneticsd : BMJg 53:12, s. 835-45q 53:12<835-45x 0022-2593x 1468-6244 |
856 | 4 | u https://europepmc.org/articles/pmc5309131?pdf=render |
856 | 4 8 | u https://gup.ub.gu.se/publication/250698 |
856 | 4 8 | u https://doi.org/10.1136/jmedgenet-2016-103966 |
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