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FältnamnIndikatorerMetadata
00018904naa a2202761 4500
001oai:gup.ub.gu.se/307998
003SwePub
008240528s2021 | |||||||||||000 ||eng|
009oai:DiVA.org:uu-463090
009oai:DiVA.org:du-38289
009oai:lup.lub.lu.se:469618eb-613c-479c-b61a-126e0fbf7994
009oai:prod.swepub.kib.ki.se:147534502
024a https://gup.ub.gu.se/publication/3079982 URI
024a https://doi.org/10.1002/ehf2.135172 DOI
024a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4630902 URI
024a https://urn.kb.se/resolve?urn=urn:nbn:se:du-382892 URI
024a https://lup.lub.lu.se/record/469618eb-613c-479c-b61a-126e0fbf79942 URI
024a http://kipublications.ki.se/Default.aspx?queryparsed=id:1475345022 URI
040 a (SwePub)gud (SwePub)uud (SwePub)dud (SwePub)lud (SwePub)ki
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
100a Lumbers, R. T.u Institute of Health Informatics University College London Gower St London WC1E 7HB UK;Health Data Research UK London University College London London UK;BHF Research Accelerator University College London London UK4 aut
2451 0a The genomics of heart failure: design and rationale of the HERMES consortium
264 c 2021-09-03
264 1b Wiley,c 2021
520 a Aims The HERMES (HEart failure Molecular Epidemiology for Therapeutic targets) consortium aims to identify the genomic and molecular basis of heart failure. Methods and results The consortium currently includes 51 studies from 11 countries, including 68 157 heart failure cases and 949 888 controls, with data on heart failure events and prognosis. All studies collected biological samples and performed genome-wide genotyping of common genetic variants. The enrolment of subjects into participating studies ranged from 1948 to the present day, and the median follow-up following heart failure diagnosis ranged from 2 to 116 months. Forty-nine of 51 individual studies enrolled participants of both sexes; in these studies, participants with heart failure were predominantly male (34-90%). The mean age at diagnosis or ascertainment across all studies ranged from 54 to 84 years. Based on the aggregate sample, we estimated 80% power to genetic variant associations with risk of heart failure with an odds ratio of >1.10 for common variants (allele frequency > 0.05) and >1.20 for low-frequency variants (allele frequency 0.01-0.05) at P < 5 x 10(-8) under an additive genetic model. Conclusions HERMES is a global collaboration aiming to (i) identify the genetic determinants of heart failure; (ii) generate insights into the causal pathways leading to heart failure and enable genetic approaches to target prioritization; and (iii) develop genomic tools for disease stratification and risk prediction.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
653 a Heart failure
653 a Cardiomyopathy
653 a Genetics
653 a Biomarkers
653 a Association studies
653 a wide association
653 a african ancestry
653 a aging research
653 a epidemiology
653 a metaanalysis
653 a classification
653 a replication
653 a cohorts
653 a adults
653 a risk
653 a Cardiovascular System & Cardiology
653 a Heart failure
700a Shah, S.u Institute for Molecular Bioscience The University of Queensland Brisbane Queensland Australia;Institute of Cardiovascular Science University College London London UK,Division of Molecular and Clinical Medicine University of Dundee, Ninewells Hospital and Medical School Dundee UK4 aut
700a Lin, H. H.u Section of Computational Biomedicine, Department of Medicine Boston University School of Medicine Boston MA USA;National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study Framingham MA USA,Institute of Health Informatics University College London Gower St London WC1E 7HB UK;Health Data Research UK London University College London London UK;The National Institute for Health Research University College London Hospitals Biomedical Research Centre, University College London London UK,Division of Cardiology, Department of Medicine Emory University Medical Center Atlanta GA USA4 aut
700a Czuba, Tomaszu Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital4 aut0 (Swepub:lu)to6882cz
700a Henry, A.u Institute of Health Informatics University College London Gower St London WC1E 7HB UK;Institute of Cardiovascular Science University College London London UK4 aut
700a Swerdlow, D. I.u Institute of Cardiovascular Science University College London London UK;Department of Medicine Imperial College London London UK4 aut
700a Malarstig, A.u Karolinska Institute,Pfizer Inc. US4 aut
700a Andersson, C.u National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study Framingham MA USA;Department of Cardiology Herlev Gentofte Hospital Herlev Denmark4 aut
700a Verweij, N.u Department of Cardiology University of Groningen, University Medical Center Groningen Groningen The Netherlands4 aut
700a Holmes, M. V.u Medical Research Council Population Health Research Unit at the University of Oxford Oxford UK;Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, Big Data Institute University of Oxford Oxford UK;National Institute for Health Research Oxford Biomedical Research Centre Oxford University Hospital Oxford UK,Oxford University Hospitals NHS Foundation Trust4 aut
700a Ärnlöv, Johan,d 1970-u Karolinska Institute,Dalarna University College,Högskolan Dalarna,Medicinsk vetenskap,Karolinska Institutet, Stockholm4 aut0 (Swepub:du)jan
700a Svensson, P.u Karolinska Institutet,Karolinska Institute,Stockholm South General Hospital4 aut
700a Hemingway, H.u Regeneron Genetics Center Tarrytown NY USA,Regeneron Pharmaceuticals, Inc.4 aut
700a Sallah, N.u Institute of Health Informatics University College London Gower St London WC1E 7HB UK;Health Data Research UK London University College London London UK;UCL Genetics Institute University College London London UK4 aut
700a Almgren, Peteru Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups4 aut0 (Swepub:lu)endo-pal
700a Aragam, K. G.u Program in Medical and Population Genetics The Broad Institute of MIT and Harvard Cambridge MA USA;Center for Genomic Medicine Massachusetts General Hospital Boston MA USA;Cardiovascular Research Center Massachusetts General Hospital Boston MA USA4 aut
700a Asselin, G.u Montreal Heart Institute Montreal Quebec Canada4 aut
700a Backman, J. D.u Regeneron Genetics Center Tarrytown NY USA,Regeneron Pharmaceuticals, Inc.4 aut
700a Lind, Larsu Uppsala universitet,Klinisk epidemiologi,Washington University School of Medicine4 aut0 (Swepub:uu)larslind
700a Bloom, H. L.4 aut
700a Boersma, E.u Erasmus MC University Medical Center Rotterdam Rotterdam The Netherlands4 aut
700a Brandimarto, J.u Penn Cardiovascular Institute, Perelman School of Medicine University of Pennsylvania Philadelphia PA USA4 aut
700a Brown, M. R.u Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health The University of Texas Health Science Center at Houston Houston TX USA4 aut
700a Brunner-La Rocca, H. P.u Maastricht University Medical Center Maastricht The Netherlands,Yukioka Hospital4 aut
700a Carey, D. J.u Department of Molecular and Functional Genomics Geisinger Danville PA USA,Geisinger Health System4 aut
700a Chaffin, M. D.u Cardiovascular Disease Initiative The Broad Institute of MIT and Harvard Cambridge MA USA,Department of Internal Medicine B University Medicine Greifswald Greifswald Germany;DZHK (German Center for Cardiovascular Research), partner site Greifswald Greifswald Germany,University Hospital Greifswald4 aut
700a Chasman, D. I.u Division of Preventive Medicine Brigham and Women's Hospital Boston MA USA;Harvard Medical School Boston MA USA4 aut
700a Chazara, O.u Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&amp;D AstraZeneca Cambridge UK4 aut
700a Chen, X.u Karolinska Institute4 aut
700a Chen, X.4 aut
700a Chung, J. H.4 aut
700a Chutkow, W.u Novartis Institutes for Biomedical Research Cambridge MA USA,Novartis Institutes for BioMedical Research, Inc.4 aut
700a Cleland, J. G. F.u Robertson Centre for Biostatistics &amp; Glasgow Clinical Trials Unit, Institute of Health and Wellbeing University of Glasgow, Glasgow Royal Infirmary Glasgow UK;National Heart and Lung Institute Imperial College London UK,Institute of Health Informatics University College London Gower St London WC1E 7HB UK;Health Data Research UK London University College London London UK,Translational and Clinical Research Servier Cardiovascular Center for Therapeutic Innovation Suresnes France4 aut
700a Cook, J. P.u Department of Biostatistics University of Liverpool Liverpool UK4 aut
700a de Denus, S.u Montreal Heart Institute Montreal Quebec Canada;Faculty of Pharmacy Université de Montréal Montreal Quebec Canada4 aut
700a Dehghan, A.u Department of Epidemiology and Biostatistics Imperial College London, St Mary's Campus London UK;MRC‐PHE Centre for Environment and Health, Department of Epidemiology and Biostatistics Imperial College London, St Mary's Campus London UK4 aut
700a Engström, Gunnaru Lund University,Lunds universitet,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Cardiovascular Research - Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)smi-gen
700a Denaxas, S.u Institute of Health Informatics University College London Gower St London WC1E 7HB UK;Health Data Research UK London University College London London UK;The National Institute for Health Research University College London Hospitals Biomedical Research Centre, University College London London UK;The Alan Turing Institute, British Library London UK4 aut
700a Doney, A. S.4 aut
700a Dorr, M.4 aut
700a Dudley, S. C.u Cardiovascular Division, Department of Medicine University of Minnesota Minneapolis MN USA4 aut
700a Engstrom, G.4 aut
700a Esko, T.u Program in Medical and Population Genetics The Broad Institute of MIT and Harvard Cambridge MA USA;Estonian Genome Center, Institute of Genomics University of Tartu Tartu Estonia4 aut
700a Fatemifar, G.4 aut
700a Felix, S. B.u Department of Internal Medicine B University Medicine Greifswald Greifswald Germany;DZHK (German Center for Cardiovascular Research), partner site Greifswald Greifswald Germany,University Hospital Greifswald4 aut
700a Finan, C.u Institute of Cardiovascular Science University College London London UK4 aut
700a Ford, I.u Robertson Centre for Biostatistics &amp; Glasgow Clinical Trials Unit, Institute of Health and Wellbeing University of Glasgow, Glasgow Royal Infirmary Glasgow UK4 aut
700a Fougerousse, F.4 aut
700a Fouodjio, R.u Montreal Heart Institute Montreal Quebec Canada4 aut
700a Ghanbari, M.u Department of Epidemiology Erasmus University Medical Center Rotterdam The Netherlands4 aut
700a Ghasemi, S.4 aut
700a Giedraitis, Vilmantasu Uppsala universitet,Geriatrik4 aut0 (Swepub:uu)vigie517
700a Giulianini, F.4 aut
700a Gottdiener, J. S.4 aut
700a Gross, S.4 aut
700a Gudbjartsson, D. F.4 aut
700a Gui, H. S.4 aut
700a Gutmann, R.4 aut
700a Haggerty, C. M.4 aut
700a van der Harst, P.4 aut
700a Helgadottir, A.4 aut
700a Hillege, H.4 aut
700a Hyde, C. L.4 aut
700a Smith, J. Gustav,d 1982u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberglaboratoriet,Institute of Medicine, Department of Molecular and Clinical Medicine,Wallenberg Laboratory4 aut0 (Swepub:gu)xsmigu
700a Jukema, J. W.4 aut
700a Kamanu, F.4 aut
700a Kardys, I.4 aut
700a Kavousi, M.4 aut
700a Khaw, K. T.4 aut
700a Kleber, M. E.4 aut
700a Kober, L.4 aut
700a Koekemoer, A.u Karolinska Institutet4 aut
700a Kraus, B.4 aut
700a Kuchenbaecker, K.4 aut
700a Langenberg, C.4 aut
700a Lind, L.4 aut
700a Lindgren, C. M.u Broad Institute,University of Oxford,Wellcome Trust Centre for Human Genetics4 aut
700a London, B.4 aut
700a Lotta, L. A.4 aut
700a Lovering, R. C.4 aut
700a Luan, J. A.4 aut
700a Magnusson, P.4 aut
700a Mahajan, A.4 aut
700a Mann, D.4 aut
700a Margulies, K. B.4 aut
700a Marston, N. A.4 aut
700a Marz, W.4 aut
700a McMurray, J. J. V.4 aut
700a Melander, Olleu Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)endo-ome
700a Melloni, G.4 aut
700a Mordi, I. R.4 aut
700a Perola, Markusu Finnish National Institute for Health and Welfare4 aut0 (Swepub:lu)med-mkp
700a Morris, A. D.4 aut
700a Morris, A. P.4 aut
700a Morrison, A. C.4 aut
700a Nagle, M. W.4 aut
700a Nelson, C. P.4 aut
700a Newton-Cheh, C.4 aut
700a Niessner, A.4 aut
700a Niiranen, T.4 aut
700a Nowak, C.u Karolinska Institutet4 aut
700a O'Donoghue, M. L.4 aut
700a Owens, A. T.4 aut
700a Palmer, C. N. A.4 aut
700a Pare, G.4 aut
700a Perola, M.4 aut
700a Perreault, L. P. L.4 aut
700a Portilla-Fernandez, E.4 aut
700a Psaty, B. M.4 aut
700a Rice, K. M.4 aut
700a Ridker, P. M.4 aut
700a Romaine, S. P. R.4 aut
700a Roselli, C.4 aut
700a Rotter, J. I.4 aut
700a Ruff, C. T.4 aut
700a Sabatine, M. S.4 aut
700a Salo, P.4 aut
700a Salomaa, V.4 aut
700a van Setten, J.4 aut
700a Shalaby, A. A.4 aut
700a Smelser, D. T.4 aut
700a Smith, N. L.4 aut
700a Stefansson, K.4 aut
700a Stender, S.4 aut
700a Stott, D. J.4 aut
700a Sveinbjornsson, G.4 aut
700a Tammesoo, M. L.4 aut
700a Tardif, J. C.4 aut
700a Taylor, K. D.4 aut
700a Teder-Laving, M.4 aut
700a Teumer, A.4 aut
700a Thorgeirsson, G.4 aut
700a Thorsteinsdottir, U.4 aut
700a Torp-Pedersen, C.4 aut
700a Trompet, S.4 aut
700a Tuckwell, D.4 aut
700a Tyl, B.4 aut
700a Uitterlinden, A. G.4 aut
700a Vaura, F.4 aut
700a Veluchamy, A.4 aut
700a Visscher, P. M.4 aut
700a Volker, U.4 aut
700a Voors, A. A.4 aut
700a Wang, X. S.4 aut
700a Wareham, N. J.4 aut
700a Weeke, P. E.4 aut
700a Weiss, R.4 aut
700a White, H. D.4 aut
700a Wiggins, K. L.4 aut
700a Xing, H. M.4 aut
700a Yang, J.4 aut
700a Yang, Y. F.4 aut
700a Yerges-Armstrong, L. M.4 aut
700a Yu, B.4 aut
700a Zannad, F.4 aut
700a Zhao, F. Y.4 aut
700a Wilk, J. B.4 aut
700a Holm, H.4 aut
700a Sattar, N.4 aut
700a Lubitz, S. A.4 aut
700a Lanfear, D. E.4 aut
700a Shah, S.4 aut
700a Dunn, M. E.4 aut
700a Wells, Q. S.4 aut
700a Asselbergs, F. W.4 aut
700a Hingorani, A. D.4 aut
700a Dube, M. P.4 aut
700a Samani, N. J.4 aut
700a Lang, C. C.4 aut
700a Cappola, T. P.4 aut
700a Ellinor, P. T.4 aut
700a Vasan, R. S.4 aut
700a Smith, J. Gustav,d 1982u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberglaboratoriet,Institute of Medicine, Department of Molecular and Clinical Medicine,Wallenberg Laboratory4 aut0 (Swepub:gu)xsmigu
710a Institute of Health Informatics University College London Gower St London WC1E 7HB UK;Health Data Research UK London University College London London UK;BHF Research Accelerator University College London London UKb Institute for Molecular Bioscience The University of Queensland Brisbane Queensland Australia;Institute of Cardiovascular Science University College London London UK4 org
710a Regeneron Genetics Center
773t Esc Heart Failured : Wileyg 8:6, s. 5531-5541q 8:6<5531-5541x 2055-5822
856u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ehf2.13517
856u https://doi.org/10.1002/ehf2.13517y Fulltext
856u https://uu.diva-portal.org/smash/get/diva2:1625037/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
856u https://du.diva-portal.org/smash/get/diva2:1597601/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
856u http://dx.doi.org/10.1002/ehf2.13517x freey FULLTEXT
8564 8u https://gup.ub.gu.se/publication/307998
8564 8u https://doi.org/10.1002/ehf2.13517
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-463090
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:du-38289
8564 8u https://lup.lub.lu.se/record/469618eb-613c-479c-b61a-126e0fbf7994
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:147534502

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Av författaren/redakt...
Lumbers, R. T.
Shah, S.
Lin, H. H.
Czuba, Tomasz
Henry, A.
Swerdlow, D. I.
visa fler...
Malarstig, A.
Andersson, C.
Verweij, N.
Holmes, M. V.
Ärnlöv, Johan, 1 ...
Svensson, P.
Hemingway, H.
Sallah, N.
Almgren, Peter
Aragam, K. G.
Asselin, G.
Backman, J. D.
Lind, Lars
Bloom, H. L.
Boersma, E.
Brandimarto, J.
Brown, M. R.
Brunner-La Rocca ...
Carey, D. J.
Chaffin, M. D.
Chasman, D. I.
Chazara, O.
Chen, X.
Chung, J. H.
Chutkow, W.
Cleland, J. G. F ...
Cook, J. P.
de Denus, S.
Dehghan, A.
Engström, Gunnar
Denaxas, S.
Doney, A. S.
Dorr, M.
Dudley, S. C.
Engstrom, G.
Esko, T.
Fatemifar, G.
Felix, S. B.
Finan, C.
Ford, I.
Fougerousse, F.
Fouodjio, R.
Ghanbari, M.
Ghasemi, S.
Giedraitis, Vilm ...
Giulianini, F.
Gottdiener, J. S ...
Gross, S.
Gudbjartsson, D. ...
Gui, H. S.
Gutmann, R.
Haggerty, C. M.
van der Harst, P ...
Helgadottir, A.
Hillege, H.
Hyde, C. L.
Smith, J. Gustav ...
Jukema, J. W.
Kamanu, F.
Kardys, I.
Kavousi, M.
Khaw, K. T.
Kleber, M. E.
Kober, L.
Koekemoer, A.
Kraus, B.
Kuchenbaecker, K ...
Langenberg, C.
Lind, L.
Lindgren, C. M.
London, B.
Lotta, L. A.
Lovering, R. C.
Luan, J. A.
Magnusson, P.
Mahajan, A.
Mann, D.
Margulies, K. B.
Marston, N. A.
Marz, W.
McMurray, J. J. ...
Melander, Olle
Melloni, G.
Mordi, I. R.
Perola, Markus
Morris, A. D.
Morris, A. P.
Morrison, A. C.
Nagle, M. W.
Nelson, C. P.
Newton-Cheh, C.
Niessner, A.
Niiranen, T.
Nowak, C.
O'Donoghue, M. L ...
Owens, A. T.
Palmer, C. N. A.
Pare, G.
Perola, M.
Perreault, L. P. ...
Portilla-Fernand ...
Psaty, B. M.
Rice, K. M.
Ridker, P. M.
Romaine, S. P. R ...
Roselli, C.
Rotter, J. I.
Ruff, C. T.
Sabatine, M. S.
Salo, P.
Salomaa, V.
van Setten, J.
Shalaby, A. A.
Smelser, D. T.
Smith, N. L.
Stefansson, K.
Stender, S.
Stott, D. J.
Sveinbjornsson, ...
Tammesoo, M. L.
Tardif, J. C.
Taylor, K. D.
Teder-Laving, M.
Teumer, A.
Thorgeirsson, G.
Thorsteinsdottir ...
Torp-Pedersen, C ...
Trompet, S.
Tuckwell, D.
Tyl, B.
Uitterlinden, A. ...
Vaura, F.
Veluchamy, A.
Visscher, P. M.
Volker, U.
Voors, A. A.
Wang, X. S.
Wareham, N. J.
Weeke, P. E.
Weiss, R.
White, H. D.
Wiggins, K. L.
Xing, H. M.
Yang, J.
Yang, Y. F.
Yerges-Armstrong ...
Yu, B.
Zannad, F.
Zhao, F. Y.
Wilk, J. B.
Holm, H.
Sattar, N.
Lubitz, S. A.
Lanfear, D. E.
Dunn, M. E.
Wells, Q. S.
Asselbergs, F. W ...
Hingorani, A. D.
Dube, M. P.
Samani, N. J.
Lang, C. C.
Cappola, T. P.
Ellinor, P. T.
Vasan, R. S.
visa färre...
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MEDICIN OCH HÄLS ...
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och Kardiologi
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Högskolan Dalarna
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