Prolonged moderate pressure recruitment manoeuvre results in lower optimal positive end-expiratory pressure and plateau pressure.

• In acute lung injury (ALI)/acute respiratory distress syndrome (ARDS), recruitment manoeuvres (RMs) are used frequently. In pigs with induced ALI, superior effects have been found using a slow moderate-pressure recruitment manoeuvre (SLRM) compared with a vital capacity recruitment manoeuvre (VICM). We hypothesized that the positive recruitment effects of SLRM could also be achieved in ALI/ARDS patients. Our primary research question was whether the same compliance could be obtained using lower RM pressure and subsequent positive end-expiratory pressure (PEEP). Secondly, optimal PEEP levels following the RMs were compared, and the use of volume-dependent compliance (VDC) to identify successful lung recruitment and optimal PEEP was evaluated.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Anestesi och intensivvård (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Anesthesiology and Intensive Care (hsv//eng)

Nyckelord

Acute Lung Injury

physiopathology

therapy

Aged

Anesthetics

Intravenous

pharmacology

Cardiac Output

physiology

Cross-Over Studies

Electric Impedance

Female

Fentanyl

pharmacology

Humans

Hypnotics and Sedatives

pharmacology

Lung Compliance

physiology

Lung Volume Measurements

Male

Middle Aged

Positive-Pressure Respiration

methods

Propofol

pharmacology

Prospective Studies

Pulmonary Gas Exchange

physiology

Respiration

Artificial

Respiratory Distress Syndrome

Adult

physiopathology

therapy

Respiratory Mechanics

physiology

Vital Capacity

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)