Sökning: WFRF:(Lysholm J) >
Genome-wide SNP ana...
Genome-wide SNP analysis reveals no gain in power for association studies of common variants in the Finnish Saami
-
- Huyghe, Jeroen R. (författare)
- Department of Medical Genetics, University of Antwerp, Antwerp, Belgium
-
- Fransen, Erik (författare)
- Department of Medical Genetics, University of Antwerp, Antwerp, Belgium
-
- Hannula, Samuli (författare)
- Department of Otorhinolaryngology, University of Oulu, Oulu, Finland
-
visa fler...
-
- Van Laer, Lut (författare)
- Department of Medical Genetics, University of Antwerp, Antwerp, Belgium
-
- Van Eyken, Els (författare)
- Department of Medical Genetics, University of Antwerp, Antwerp, Belgium
-
- Mäki-Torkko, Elina, 1961- (författare)
- Östergötlands Läns Landsting,Linköpings universitet,Örebro universitet,Institutionen för medicinska vetenskaper,Department of Otorhinolaryngology, University of Oulu, Oulu, Finland,Hälsouniversitetet,Öronkliniken US
-
- Lysholm-Bernacchi, Alana, 1974-2007 (författare)
- Neurogenomics Division, Translational Genomics Research Institute, Phoenix AZ, USA
-
- Aikio, Pekka (författare)
- Thule Institute, University of Oulu, Oulu, Finland
-
- Stephan, Dietrich A. (författare)
- Neurogenomics Division, Translational Genomics Research Institute, Phoenix AZ, USA
-
- Sorri, Martti (författare)
- Department of Otorhinolaryngology, University of Oulu, Oulu, Finland
-
- Huentelman, Matthew J. (författare)
- Neurogenomics Division, Translational Genomics Research Institute, Phoenix AZ, USA
-
- Van Camp, Guy (författare)
- Department of Medical Genetics, University of Antwerp, Antwerp, Belgium
-
visa färre...
-
(creator_code:org_t)
- 2009-11-25
- 2010
- Engelska.
-
Ingår i: European Journal of Human Genetics. - : Nature Publishing Group. - 1018-4813 .- 1476-5438. ; 18:5, s. 569-574
- Relaterad länk:
-
https://www.nature.c...
-
visa fler...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
visa färre...
Abstract
Ämnesord
Stäng
- The Saami from Fennoscandia are believed to represent an ancient, genetically isolated population with no evidence of population expansion. Theoretical work has indicated that under this demographic scenario, extensive linkage disequilibrium (LD) is generated by genetic drift. Therefore, it has been suggested that the Saami would be particularly suited for genetic association studies, offering a substantial power advantage and allowing more economic study designs. However, no study has yet assessed this claim. As part of a GWAS for a complex trait, we evaluated the relative power for association studies of common variants in the Finnish Saami. LD patterns in the Saami were very similar to those in the non-African HapMap reference panels. Haplotype diversity was reduced and, on average, levels of LD were higher in the Saami as compared with those in the HapMap panels. However, using a 'hidden' SNP approach we show that this does not translate into a power gain in association studies. Contrary to earlier claims, we show that for a given set of common SNPs, genomic coverage attained in the Saami is similar to that in the non-African HapMap panels. Nevertheless, the reduced haplotype diversity could potentially facilitate gene identification, especially if multiple rare variants play a role in disease etiology. Our results further indicate that the HapMap is a useful resource for genetic studies in the Saami.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Oto-rhino-laryngologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Otorhinolaryngology (hsv//eng)
Nyckelord
- Saami; genome-wide association studies; linkage disequilibrium; population isolates
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Huyghe, Jeroen R ...
-
Fransen, Erik
-
Hannula, Samuli
-
Van Laer, Lut
-
Van Eyken, Els
-
Mäki-Torkko, Eli ...
-
visa fler...
-
Lysholm-Bernacch ...
-
Aikio, Pekka
-
Stephan, Dietric ...
-
Sorri, Martti
-
Huentelman, Matt ...
-
Van Camp, Guy
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Medicinska och f ...
-
och Medicinsk geneti ...
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Oto rhino laryng ...
- Artiklar i publikationen
-
European Journal ...
- Av lärosätet
-
Örebro universitet
-
Linköpings universitet