Improvements in absorbed dose measurements for external radiation therapy using ferrous dosimeter gel and MR imaging (FeMRI)

Bäck, SvenLund University,Lunds universitet,Medicinsk strålningsfysik, Malmö,Forskargrupper vid Lunds universitet,Medical Radiation Physics, Malmö,Lund University Research Groups (författare)

A ferrous gel, based on ferrous (Fe) sulphate and agarose, was used with a clinical magnetic resonance imaging (MRI) scanner to obtain relative dose distribution data from therapeutic photon and electron beams. The FeMRI gel was scanned using a new MRI acquisition protocol optimized for T1 measurements. Thorough comparisons with silicon semiconductor detector and ionization chamber measurements, as well as with Monte Carlo calculations, were performed in order to quantify the improvements obtained using FeMRI for dose estimations. Most of the relative doses measured with FeMRI were within 2% of the doses measured with other methods. The larger discrepancies (2-4%) found at shallow depths are discussed. The uncertainty in relative dose measurements using FeMRI was significantly improved compared with previously reported results (5-10%, one standard deviation, 1 SD), and is today between 1.6% and 3.3% (depending on dose level, 2 SD). This corresponds to an improvement in the minimum detectable dose (3 SD above background) from approximately 2 Gy to better than 0.6 Gy. The results obtained in this study emphasize the importance of obtaining basic FeMRI dose data before the method is extended to complicated treatment regimes.

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Radiologi och bildbehandling hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Radiology, Nuclear Medicine and Medical Imaging hsv//eng
Electrons
Ferrous Compounds
Gels
Magnetic Resonance Imaging
Phantoms, Imaging
Photons
Radiotherapy Dosage
Radiotherapy Planning, Computer-Assisted
Radiotherapy, High-Energy
Reproducibility of Results
Sepharose

Magnusson, PeterLund University,Lunds universitet,Medicinsk strålningsfysik, Malmö,Forskargrupper vid Lunds universitet,Medical Radiation Physics, Malmö,Lund University Research Groups(Swepub:lu)extLU-696 (författare)
Fransson, A (författare)
Olsson, L ELund University,Lunds universitet,Medicinsk strålningsfysik, Malmö,Forskargrupper vid Lunds universitet,Medical Radiation Physics, Malmö,Lund University Research Groups(Swepub:lu)rfa-lol (författare)
Montelius, AUppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi,Sjukhusfysik (författare)
Holmberg, OSt Luke's Hospital(Swepub:lu)rfa-oho (författare)
Andreo, PKarolinska Institutet (författare)
Mattsson, SLund University,Lunds universitet,Medicinsk strålningsfysik, Malmö,Forskargrupper vid Lunds universitet,Medical Radiation Physics, Malmö,Lund University Research Groups(Swepub:lu)rfa-sma (författare)
Medicinsk strålningsfysik, MalmöForskargrupper vid Lunds universitet (creator_code:org_t)

Ingår i:Physics in Medicine and Biology: IOP Publishing43, s. 261-0031-91551361-6560
Ingår i:Phys Med Biol: IOP Publishing43, s. 261-

Av författaren/redakt...: Bäck, Sven; Magnusson, Peter; Fransson, A; Olsson, L E; Montelius, A; Holmberg, O; visa fler...; Andreo, P; Mattsson, S; visa färre...

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