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Single-file electro...
Single-file electrophoretic transport and counting of individual DNA molecules in surfactant nanotubes
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- Tokarz, Michal, 1976 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Åkerman, Björn, 1957 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Olofsson, Jessica, 1975 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Joanny, J. F. (författare)
- Physico-Chimie Curie
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- Dommersnes, P. (författare)
- Physico-Chimie Curie
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- Orwar, Owe, 1964 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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(creator_code:org_t)
- 2005-06-16
- 2005
- Engelska.
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Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 0027-8424 .- 1091-6490. ; 102:26, s. 9127-9132
- Relaterad länk:
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http://dx.doi.org/10...
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http://www.pnas.org/...
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https://research.cha...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- We demonstrate a complete nanotube electrophoresis system (nanotube radii in the range of 50 to 150 nm) based on lipid membranes, comprising DNA injection, single-molecule transport, and single-molecule detection. Using gel-capped electrodes, electrophoretic single-file transport of fluorescently labeled dsDNA molecules is observed inside nanotubes. The strong confinement to a channel of molecular dimensions ensures a detection efficiency close to unity and identification of DNA size from its linear relation to the integrated peak intensity. In addition to constituting a nanotechnological device for identification and quantification of single macromolecules or biopolymers, this system provides a method to study their conformational dynamics, reaction kinetics, and transport in cell-like environments.
Ämnesord
- TEKNIK OCH TEKNOLOGIER -- Kemiteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Chemical Engineering (hsv//eng)
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