Left ventricular twist is load-dependent as shown in a large animal model with controlled cardiac load

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A'Roch, RomanUmeå universitet,Anestesiologi och intensivvård (författare)

Left ventricular twist is load-dependent as shown in a large animal model with controlled cardiac load

Artikel/kapitelEngelska2012

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2012-06-25
BioMed Central,2012
electronicrdacarrier

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LIBRIS-ID:oai:DiVA.org:umu-59414
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-59414URI
https://doi.org/10.1186/1476-7120-10-26DOI

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Språk:engelska
Sammanfattning på:engelska

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BACKGROUND: Left ventricular rotation and twist can be assessed noninvasively by speckle tracking echocardiography. We sought to characterize the effects of acute load change and change in inotropic state on rotation parameters as a measure of left ventricular (LV) contractility.METHODS: Seven anesthetised juvenile pigs were studied, using direct measurement of left ventricular pressure and volume and simultaneous transthoracic echocardiography. Transient inflation of an inferior vena cava balloon (IVCB) catheter produced controlled load reduction. First and last beats in the sequence of eight were analysed with speckle tracking (STE) during the load alteration and analysed for change in rotation/twist during controlled load alteration at same contractile status. Two pharmacological inotropic interventions were also included to examine the same hypothesis in additionally conditions of increased and decreased myocardial contractility in each animal. Paired comparisons were made for different load states using the Wilcoxon's Signed Rank test.RESULTS: The inferior vena cava balloon occlusion (IVCBO) load change compared for first to last beat resulted in LV twist increase (11.67degrees +/-2.65degrees vs. 16.17degrees +/-3.56degrees respectively, p < 0.004) during the load alteration and under adrenaline stimulation LV twist increase 12.56degrees +/-5.1degrees vs. 16.57degrees +/-4.6degrees (p < 0.013), and though increased, didn't reach significance in negative inotropic condition. Untwisting rate increased significantly at baseline from 41.7degrees/s +/-41.6degrees/s vs.122.6degrees/s +/-55.8degrees/s (P < 0.039) and under adrenaline stimulation untwisting rate increased (55.3degrees/s +/-3.8degrees/s vs.111.4degrees/s +/-24.0degrees/s (p < 0.05), but did not systematically changed in negative inotropic condition.CONCLUSIONS: Peak systolic LV twist and peak early diastolic untwisting rate are load dependent. Differences in LV load should be included in the interpretation when serial measures of twist are compared.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Fysiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Physiology hsv//eng
Echocardiography
Ventricular function
Rotation
Torsion
Load

Biuppslag (personer, institutioner, konferenser, titlar ...)

Gustafsson, UlfUmeå universitet,Kardiologi(Swepub:umu)ulfgun98 (författare)
Poelaert, JanAnesthesiology, University of Brussels, Belgium (författare)
Johansson, GöranUmeå universitet,Anestesiologi och intensivvård(Swepub:umu)gojo0001 (författare)
Haney, MichaelUmeå universitet,Anestesiologi och intensivvård(Swepub:umu)milhay96 (författare)
Umeå universitetAnestesiologi och intensivvård (creator_code:org_t)

Sammanhörande titlar

Ingår i:Cardiovascular Ultrasound: BioMed Central101476-7120

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Av författaren/redakt...: A'Roch, Roman; Gustafsson, Ulf; Poelaert, Jan; Johansson, Göran; Haney, Michael

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Medicinska och f ...; och Fysiologi

Artiklar i publikationen: Cardiovascular U ...

Av lärosätet: Umeå universitet

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