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Sökning: L773:0966 3274 OR L773:1878 5492 > T-cell inhibition d...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03217naa a2200385 4500 | |
| 001 | oai:DiVA.org:uu-93479 | |
| 003 | SwePub | |
| 008 | 050915s2006 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-934792 URI |
| 024 | 7 | a https://doi.org/10.1016/j.trim.2006.09.0242 DOI |
| 040 | a (SwePub)uu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Stenbäck, Andersu Uppsala universitet,Transplantationskirurgi,Barnkirurgi4 aut0 (Swepub:uu)andesten |
| 245 | 1 0 | a T-cell inhibition does not aggravate bacterial translocation from rat small bowel |
| 264 | 1 | b Elsevier BV,c 2006 |
| 338 | a print2 rdacarrier | |
| 520 | a Background: T-cell mediated immunity has been proposed to have an important function in the defence against translocating microbes from the gastrointestinal tract. After small bowel transplantation massive T-cell immunosuppression is necessary to avoid rejection. As a consequence, infections with intestinal bacteria are the main contributors to mortality in this setting. This could further imply that T cells are important in limiting bacterial translocation. In a model for bacterial translocation from small bowel in the rat we examined the outcome of T-cell inactivation. Methods: The studies were performed in a model of bacterial translocation from a Thiry-Vella loop of small bowel in the rat. The animals were treated with an anti-α/β T-cell receptor monoclonal antibody (R73). Inhibition of T-cell activation was also made using the immunosuppressive drug cyclosporin A. All animals were sacrificed on day 3 postoperatively and translocation to the mesenteric lymph nodes, liver, spleen, lung and blood was evaluated. Results: Treatment with R73 resulted in an almost complete labelling of T cells but did not result in any increased bacterial translocation compared to animals treated with saline. Neither did immunosuppression with cyclosporin A. Conclusions: In the model of bacterial translocation from a defunctionalised loop of small bowel the inhibition of T cells does not increase bacterial translocation to mesenteric lymph nodes or promote the systemic spread of the translocating bacteria. This indicates that T cells do not have any important protective function against translocating microbes from defunctionalised small bowel. | |
| 653 | a Cyclosporin | |
| 653 | a Defunctionalised bowel | |
| 653 | a Mucosal barrier | |
| 653 | a R73 | |
| 653 | a Small bowel transplantation | |
| 653 | a Thiry-Vella loop | |
| 653 | a MEDICINE | |
| 653 | a MEDICIN | |
| 700 | 1 | a Lorant, Tomasu Uppsala universitet,Transplantationskirurgi4 aut0 (Swepub:uu)tomalora |
| 700 | 1 | a Meurling, Staffanu Uppsala universitet,Barnkirurgi4 aut |
| 700 | 1 | a Johnsson, Ceciliau Uppsala universitet,Transplantationskirurgi4 aut0 (Swepub:uu)cecijohn |
| 710 | 2 | a Uppsala universitetb Transplantationskirurgi4 org |
| 773 | 0 | t Transplant Immunologyd : Elsevier BVg 16:3-4, s. 208-214q 16:3-4<208-214x 0966-3274x 1878-5492 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-93479 |
| 856 | 4 8 | u https://doi.org/10.1016/j.trim.2006.09.024 |
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