Gestational weight gain and adiposity, fat distribution, metabolic profile, and blood pressure in offspring: the IDEFICS project.

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Fältnamn	Indikatorer	Metadata
000		03973naa a2200493 4500
001		oai:gup.ub.gu.se/177225
003		SwePub
008		240528s2013 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://gup.ub.gu.se/publication/1772252 URI
024	7	a https://doi.org/10.1038/ijo.2013.352 DOI
040		a (SwePub)gu
041		a eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Dello Russo, M4 aut
245	1 0	a Gestational weight gain and adiposity, fat distribution, metabolic profile, and blood pressure in offspring: the IDEFICS project.
264		c 2013-04-09
264	1	b Springer Science and Business Media LLC,c 2013
520		a Objective:To investigate the association between gestational weight gain (GWG) and total adiposity, body fat distribution, blood pressure (BP), and metabolic profile in offspring.Design:Cross-sectional study.Methods:Body mass index (BMI), waist, subscapular and tricipital skinfolds, and BP were measured and blood samples drawn in 12775 children (aged 2-9 years) from the IDEFICS cohort. Overweight/obesity was defined by IOTF criteria. Parents filled in a questionnaire investigating child and familiar medical history and lifestyle. A section was dedicated to pregnancy history (including GWG).Results:Anthropometric indices linearly and significantly increased across GWG tertiles (BMI z-score: tertile I =0.08, 0.03-0.13; tertile II =0.16, 0.12-0.21; tertile III =0.34, 0.28-0.40, P<0.01, mean, 95% CI) by analysis of covariance (ANCOVA) adjusted by child sex, age and practice of sport, birth weight, current maternal BMI, parental education, gestational age, age at delivery, alcohol and smoking during pregnancy, maternal diabetes mellitus, gestational hypertension, and breastfeeding duration. After inclusion of BMI z-score among covariates, HbA1c significantly increased across tertiles (P=0.009) while no differences were observed for BP, serum insulin, HOMA index, blood glucose and lipids. The adjusted risk of overweight/obesity significantly increased by 14 and 22% in tertiles II and III respectively, in comparison with tertile I by logistic regression analysis controlling for covariates.Conclusion:Maternal GWG is an independent predictor of total adiposity and body fat distribution in offspring during infancy. Exposure to perinatal factors should be taken into account for early prevention of overweight and obesity.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Pediatrik0 (SwePub)302212 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Pediatrics0 (SwePub)302212 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
653		a gestational weight gain
653		a perinatal factors
653		a childhood obesity
653		a offspring BMI
653		a offspring metabolic profile
653		a offspring blood pressure
700	1	a Ahrens, W4 aut
700	1	a De Vriendt, T4 aut
700	1	a Mårild, Staffan,d 1945u Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics4 aut0 (Swepub:gu)xmarst
700	1	a Molnar, D4 aut
700	1	a Moreno, L A4 aut
700	1	a Reeske, A4 aut
700	1	a Veidebaum, T4 aut
700	1	a Kourides, Y A4 aut
700	1	a Barba, G4 aut
700	1	a Siani, A4 aut
710	2	a Göteborgs universitetb Institutionen för kliniska vetenskaper, Avdelningen för pediatrik4 org
773	0	t International Journal of Obesityd : Springer Science and Business Media LLCg 37, s. 914-919q 37<914-919x 0307-0565x 1476-5497
856	4 8	u https://gup.ub.gu.se/publication/177225
856	4 8	u https://doi.org/10.1038/ijo.2013.35

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Av författaren/redakt...: Dello Russo, M; Ahrens, W; De Vriendt, T; Mårild, Staffan, ...; Molnar, D; Moreno, L A; visa fler...; Reeske, A; Veidebaum, T; Kourides, Y A; Barba, G; Siani, A; visa färre...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Pediatrik

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Av lärosätet: Göteborgs universitet

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