Sökning: WFRF:(Cullen Nicholas C) > (2020-2024) > Tau-PET is superior...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 06203naa a2200553 4500 | |
001 | oai:lup.lub.lu.se:34a082f2-ec1c-44df-80b0-6d1e1f9e4a0b | |
003 | SwePub | |
008 | 230124s2023 | |||||||||||000 ||eng| | |
009 | oai:gup.ub.gu.se/322037 | |
024 | 7 | a https://lup.lub.lu.se/record/34a082f2-ec1c-44df-80b0-6d1e1f9e4a0b2 URI |
024 | 7 | a https://doi.org/10.1002/alz.128752 DOI |
024 | 7 | a https://gup.ub.gu.se/publication/3220372 URI |
040 | a (SwePub)lud (SwePub)gu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Smith, Rubenu Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Regeneration in Movement Disorders,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)mphy-rsm |
245 | 1 0 | a Tau-PET is superior to phospho-tau when predicting cognitive decline in symptomatic AD patients |
264 | c 2022-12-14 | |
264 | 1 | b Wiley,c 2023 |
520 | a Introduction: Biomarkers for the prediction of cognitive decline in patients with amnestic mild cognitive impairment (MCI) and amnestic mild dementia are needed for both clinical practice and clinical trials. Methods: We evaluated the ability of tau-PET (positron emission tomography), cortical atrophy on magnetic resonance imaging (MRI), baseline cognition, apolipoprotein E gene (APOE) status, plasma and cerebrospinal fluid (CSF) levels of phosphorylated tau-217, neurofilament light (NfL), and amyloid beta (Aβ)42/40 ratio (individually and in combination) to predict cognitive decline over 2 years in BioFINDER-2 and Alzheimer's Disease Neuroimaging Initiative (ADNI). Results: Baseline tau-PET and a composite baseline cognitive score were the strongest independent predictors of cognitive decline. Cortical thickness and NfL provided some additional information. Using a predictive algorithm to enrich patient selection in a theoretical clinical trial led to a significantly lower required sample size. Discussion: Models including baseline tau-PET and cognition consistently provided the best prediction of change in cognitive function over 2 years in patients with amnestic MCI or mild dementia. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng |
653 | a AD | |
653 | a blood biomarkers | |
653 | a cognition | |
653 | a PET | |
653 | a tau | |
700 | 1 | a Cullen, Nicholas C.u Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups4 aut0 (Swepub:lu)ni5875cu |
700 | 1 | a Pichet Binette, Alexau Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups4 aut0 (Swepub:lu)al1314pi |
700 | 1 | a Leuzy, Antoineu Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups4 aut0 (Swepub:lu)an3415le |
700 | 1 | a Blennow, Kaju Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xbleka |
700 | 1 | a Zetterberg, Henriku Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xzethe |
700 | 1 | a Klein, Gregoryu F. Hoffmann-La Roche AG4 aut |
700 | 1 | a Borroni, Ediliou F. Hoffmann-La Roche AG4 aut |
700 | 1 | a Ossenkoppele, Riku Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Amsterdam UMC - Vrije Universiteit Amsterdam,Vrije Universiteit Amsterdam4 aut0 (Swepub:lu)ri1513os |
700 | 1 | a Janelidze, Shorenau Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups4 aut0 (Swepub:lu)nkir-sje |
700 | 1 | a Palmqvist, Sebastianu Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)med-spa |
700 | 1 | a Mattsson-Carlgren, Niklasu Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Brain Injury After Cardiac Arrest,WCMM- Wallenberg center för molekylär medicinsk forskning,Medicinska fakulteten,Clinical Memory Research,Lund University Research Groups,WCMM-Wallenberg Centre for Molecular Medicine,Faculty of Medicine,Skåne University Hospital4 aut0 (Swepub:lu)med-nmn |
700 | 1 | a Stomrud, Eriku Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)med-esr |
700 | 1 | a Hansson, Oskaru Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)mphy-ohn |
710 | 2 | a Neurologi, Lundb Sektion IV4 org |
710 | 2 | a Alzheimer's Disease Neuroimaging Initiative |
773 | 0 | t Alzheimer's and Dementiad : Wileyg 19:6, s. 2497-2507q 19:6<2497-2507x 1552-5260x 1552-5279 |
856 | 4 | u http://dx.doi.org/10.1002/alz.12875x freey FULLTEXT |
856 | 4 8 | u https://lup.lub.lu.se/record/34a082f2-ec1c-44df-80b0-6d1e1f9e4a0b |
856 | 4 8 | u https://doi.org/10.1002/alz.12875 |
856 | 4 8 | u https://gup.ub.gu.se/publication/322037 |
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