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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003703naa a2200421 4500
001oai:DiVA.org:uu-199933
003SwePub
008130517s2013 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1999332 URI
0247 a https://doi.org/10.1016/j.jcin.2012.11.0102 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Mack, Michael J4 aut
2451 0a Analysis of Stroke Occurring in the SYNTAX Trial Comparing Coronary Artery Bypass Surgery and Percutaneous Coronary Intervention in the Treatment of Complex Coronary Artery Disease
264 1b Elsevier BV,c 2013
338 a print2 rdacarrier
520 a OBJECTIVES: This study sought to analyze stroke rates in the SYNTAX (Synergy Between Percutaneous Coronary Intervention With Taxus and Cardiac Surgery) trial's randomized and registry cohorts of patients being treated with coronary artery bypass grafting (CABG) or percutaneous coronary intervention (PCI) for treatment of complex coronary artery disease.BACKGROUND: The SYNTAX trial compared PCI to CABG in patients with de novo 3-vessel and/or left main coronary disease.METHODS: The SYNTAX randomized trial was conducted at 85 U.S. and European sites (n = 1,800). All strokes (up to 4 years) were independently adjudicated by a clinical events committee that included a neurologist. An additional 1,077 (of which 644 were followed for 5 years) and 198 patients were included in the CABG and PCI registries, respectively.RESULTS: In the randomized cohort, 31 CABG and 19 PCI patients experienced 33 and 20 strokes post-randomization at 4-year follow-up, respectively (p = 0.062). Three strokes occurred pre-procedurally but following randomization in CABG-treated patients. After CABG, a large proportion of strokes occurred acutely (0 to 30 days: 9 of 33), whereas in the PCI arm, most strokes occurred >30 days after the procedure (18 of 20). Stroke resulted in death in 3 patients in both the PCI and CABG groups. Of the patients who developed stroke, 68% (21 of 31) in the CABG group had residual deficits at discharge; in the PCI group, 47% (9 of 19) had residual deficits. In a multivariate analysis, treatment with CABG was not significantly associated with increased stroke rates (odds ratio: 1.67, 95% confidence interval: 0.93 to 3.01, p = 0.089). The incidence and outcomes of stroke were similar in the randomized trial and registries.CONCLUSIONS: There is a higher risk of periprocedural stroke in patients undergoing CABG versus PCI; however, the risk converges over the first 4 years of follow-up. (SYNTAX Study: TAXUS Drug-Eluting Stent Versus Coronary Artery Bypass Surgery for the Treatment of Narrowed Arteries; NCT00114972).
7001 a Head, Stuart J4 aut
7001 a Holmes, David R4 aut
7001 a Ståhle, Elisabethu Uppsala universitet,Thoraxkirurgi4 aut0 (Swepub:uu)elsta102
7001 a Feldman, Ted E4 aut
7001 a Colombo, Antonio4 aut
7001 a Morice, Marie-Claude4 aut
7001 a Unger, Felix4 aut
7001 a Erglis, Andrejs4 aut
7001 a Stoler, Robert4 aut
7001 a Dawkins, Keith D4 aut
7001 a Serruys, Patrick W4 aut
7001 a Mohr, Friedrich W4 aut
7001 a Kappetein, A Pieter4 aut
7102 a Uppsala universitetb Thoraxkirurgi4 org
7730 t JACC. Cardiovascular interventionsd : Elsevier BVg 6:4, s. 344-354q 6:4<344-354x 1936-8798
8564 u https://doi.org/10.1016/j.jcin.2012.11.010
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-199933
8564 8u https://doi.org/10.1016/j.jcin.2012.11.010

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