Search: WFRF:(Jansson Thomas) > Maternal hormones l...
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001 | oai:DiVA.org:hv-2757 | |
003 | SwePub | |
008 | 101020s2008 | |||||||||||000 ||eng| | |
009 | oai:DiVA.org:his-20345 | |
009 | oai:gup.ub.gu.se/71915 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:hv:diva-27572 URI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-203452 URI |
024 | 7 | a https://doi.org/10.1093/ajcn/87.6.17432 DOI |
024 | 7 | a https://gup.ub.gu.se/publication/719152 URI |
040 | a (SwePub)hvd (SwePub)hisd (SwePub)gu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Jansson, Nina,d 1976u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology4 aut0 (Swepub:gu)xjanni |
245 | 1 0 | a Maternal hormones linking maternal body mass index and dietary intake to birth weight. |
264 | 1 | a Bethesda, USA :b American Society for Nutrition,c 2008 |
338 | a print2 rdacarrier | |
520 | a BACKGROUND: Obese women often give birth to large-for-gestational age infants (typically defined as a birth weight greater than the 90th percentile), who are at risk of birth injuries and of developing metabolic syndrome later in life. The mechanisms underlying increased fetal growth remain to be established. OBJECTIVE: We aimed to identify maternal hormones that can explain the link between dietary intake, body mass index (BMI), and birth weight. DESIGN: Pregnant women with BMIs (in kg/m(2)) ranging from 17 to 44 (n = 49) were recruited in gestational weeks 8-12. Serum hormone concentrations were measured and dietary history interviews were performed in the first and third trimesters. Multiple regression models were produced to identify hormones that correlate with birth weight and are influenced by BMI or dietary factors. RESULTS: We found a strong positive correlation between BMI and first- and third-trimester insulin and leptin concentrations and a negative correlation between BMI and first-trimester adiponectin and first- and third-trimester insulin-like growth factor binding protein-1 (IGFBP-1). Maternal total fat intake in the first trimester was positively correlated with maternal leptin and inversely correlated with adiponectin. In addition, third-trimester total fat intake was positively correlated with circulating resistin concentrations. First-trimester maternal serum resistin was positively correlated with birth weight, whereas third-trimester maternal IGFBP-1 was negatively correlated with birth weight. CONCLUSIONS: High first-trimester maternal serum resistin and low third-trimester IGFBP-1 were correlated with increased birth weight. We propose that low serum concentrations of IGFBP-1 represent a link between high BMI and increased fetal growth by increasing the bioavailability of insulin-like growth factor-I, which up-regulates placental nutrient transport. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi0 (SwePub)303022 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Public Health, Global Health, Social Medicine and Epidemiology0 (SwePub)303022 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Fysiologi0 (SwePub)301062 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Physiology0 (SwePub)301062 hsv//eng |
653 | a Folkhälsovetenskap | |
653 | a Public health science | |
700 | 1 | a Nilsfelt, Annau Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology4 aut |
700 | 1 | a Gellerstedt, Martin,d 1966-u Högskolan Väst,Institutionen för ekonomi och it,Department of Informatics, University West, Trollhättan, Sweden4 aut0 (Swepub:his)gelm |
700 | 1 | a Wennergren, Margareta,d 1948u Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences4 aut0 (Swepub:gu)xwennm |
700 | 1 | a Rossander-Hulthén, Lena,d 1947u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för klinisk näringslära,Institute of Medicine, Department of Clinical Nutrition4 aut0 (Swepub:gu)xhulen |
700 | 1 | a Powell, Theresa L,d 1959u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology4 aut0 (Swepub:gu)xpowth |
700 | 1 | a Jansson, Thomas,d 1955u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology4 aut0 (Swepub:gu)xjanst |
710 | 2 | a Göteborgs universitetb Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi4 org |
773 | 0 | t American Journal of Clinical Nutritiond Bethesda, USA : American Society for Nutritiong 87:6, s. 1743-9q 87:6<1743-9x 0002-9165x 1938-3207 |
856 | 4 | u https://academic.oup.com/ajcn/article-pdf/87/6/1743/23918966/znu00608001743.pdf |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:hv:diva-2757 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-20345 |
856 | 4 8 | u https://doi.org/10.1093/ajcn/87.6.1743 |
856 | 4 8 | u https://gup.ub.gu.se/publication/71915 |
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