Comprehensive longitudinal study of epigenetic mutations in aging

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Fältnamn	Indikatorer	Metadata
000		04534naa a2200733 4500
001		oai:DiVA.org:hj-47209
003		SwePub
008		200102s2019 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:prod.swepub.kib.ki.se:142888325
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-472092 URI
024	7	a https://doi.org/10.1186/s13148-019-0788-92 DOI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1428883252 URI
040		a (SwePub)hjd (SwePub)ki
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Wang, Yunzhangu Karolinska Institutet4 aut
245	1 0	a Comprehensive longitudinal study of epigenetic mutations in aging
264		c 2019-12-09
264	1	b BioMed Central,c 2019
338		a print2 rdacarrier
520		a Background: The role of DNA methylation in aging has been widely studied. However, epigenetic mutations, here defined as aberrant methylation levels compared to the distribution in a population, are less understood. Hence, we investigated longitudinal accumulation of epigenetic mutations, using 994 blood samples collected at up to five time points from 375 individuals in old ages.Results: We verified earlier cross-sectional evidence on the increase of epigenetic mutations with age, and identified important contributing factors including sex, CD19+ B cells, genetic background, cancer diagnosis, and technical artifacts. We further classified epigenetic mutations into High/Low Methylation Outliers (HMO/LMO) according to their changes in methylation, and specifically studied methylation sites (CpGs) that were prone to mutate (frequently mutated CpGs). We validated four epigenetically mutated CpGs using pyrosequencing in 93 samples. Furthermore, by using twins, we concluded that the age-related accumulation of epigenetic mutations was not related to genetic factors, hence driven by stochastic or environmental effects.Conclusions: Here we conducted a comprehensive study of epigenetic mutation and highlighted its important role in aging process and cancer development.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng
653		a Aging
653		a Cancer
653		a Epigenetic mutation
653		a Twin study
653		a adult
653		a article
653		a artifact
653		a B lymphocyte
653		a cancer diagnosis
653		a epigenetics
653		a female
653		a genetic background
653		a human
653		a human cell
653		a human experiment
653		a human tissue
653		a longitudinal study
653		a major clinical study
653		a male
653		a methylation
653		a pyrosequencing
653		a stochastic model
700	1	a Karlsson, Robertu Karolinska Institutet4 aut
700	1	a Jylhävä, Juuliau Karolinska Institutet4 aut
700	1	a Hedman, Åsa K.u Karolinska Institutet4 aut
700	1	a Almqvist, Catarinau Karolinska Institutet4 aut
700	1	a Karlsson, Ida K.u Karolinska Institutet,Jönköping University,HHJ, Institutet för gerontologi,HHJ. ARN-J (Aging Research Network - Jönköping),Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden4 aut0 (Swepub:hj)karida
700	1	a Pedersen, Nancy L.u Karolinska Institutet4 aut
700	1	a Almgren, Malinu Department of Clinical Neuroscience, Centrum for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden4 aut
700	1	a Hägg, Sarau Karolinska Institutet4 aut
710	2	a Karolinska Institutetb HHJ, Institutet för gerontologi4 org
773	0	t Clinical Epigeneticsd : BioMed Centralg 11q 11x 1868-7083x 1868-7075
856	4	u https://doi.org/10.1186/s13148-019-0788-9y Fulltext
856	4	u https://clinicalepigeneticsjournal.biomedcentral.com/track/pdf/10.1186/s13148-019-0788-9
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-47209
856	4 8	u https://doi.org/10.1186/s13148-019-0788-9
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:142888325

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Av författaren/redakt...: Wang, Yunzhang; Karlsson, Robert; Jylhävä, Juulia; Hedman, Åsa K.; Almqvist, Catari ...; Karlsson, Ida K.; visa fler...; Pedersen, Nancy ...; Almgren, Malin; Hägg, Sara; visa färre...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Cancer och onkol ...

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