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Sökning: WFRF:(Koerkamp M. G.) > Impact of Neoadjuva...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00006334naa a2200553 4500
001oai:lup.lub.lu.se:b9de9bcd-e639-45a9-a5b1-19798046c884
003SwePub
008240327s2024 | |||||||||||000 ||eng|
009oai:DiVA.org:liu-205190
0247 a https://lup.lub.lu.se/record/b9de9bcd-e639-45a9-a5b1-19798046c8842 URI
0247 a https://doi.org/10.1097/XCS.00000000000009712 DOI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-2051902 URI
040 a (SwePub)lud (SwePub)liu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Davis, Catherine H.u Baylor Scott and White Hospital,Baylor Scott & White Hlth, TX USA4 aut
2451 0a Impact of Neoadjuvant Therapy for Pancreatic Cancer : Transatlantic Trend and Postoperative Outcomes Analysis
264 1b LIPPINCOTT WILLIAMS & WILKINS,c 2024
300 a 9 s.
520 a BACKGROUND: The introduction of modern chemotherapy a decade ago has led to increased use of neoadjuvant therapy (NAT) in patients with pancreatic ductal adenocarcinoma (PDAC). A recent North American study demonstrated increased use of NAT and improved operative outcomes in patients with PDAC. The aims of this study were to compare the use of NAT and short-term outcomes in patients with PDAC undergoing pancreatoduodenectomy (PD) among registries from the US and Canada, Germany, the Netherlands, and Sweden. STUDY DESIGN: Databases from 2 multicenter (voluntary) and 2 nationwide (mandatory) registries were queried from 2018 to 2020. Patients undergoing PD for PDAC were compared based on the use of upfront surgery vs NAT. Adoption of NAT was measured in each country over time. Thirty-day outcomes, including the composite measure (ideal outcomes), were compared by multivariable analyses. Sensitivity analyses of patients undergoing vascular resection were performed. RESULTS: Overall, 11,402 patients underwent PD for PDAC with 33.7% of patients receiving NAT. The use of NAT increased steadily from 28.3% in 2018 to 38.5% in 2020 (p < 0.0001). However, use of NAT varied widely by country: the US (46.8%), the Netherlands (44.9%), Sweden (11.0%), and Germany (7.8%). On multivariable analysis, NAT was significantly (p < 0.01) associated with reduced rates of serious morbidity, clinically relevant pancreatic fistulae, reoperations, and increased ideal outcomes. These associations remained on sensitivity analysis of patients undergoing vascular resection. CONCLUSIONS: NAT before PD for pancreatic cancer varied widely among 4 Western audits yet increased by 26% during 3 years. NAT was associated with improved short-term outcomes.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kirurgi0 (SwePub)302122 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Surgery0 (SwePub)302122 hsv//eng
7001 a Augustinus, Simoneu University of Amsterdam,Univ Amsterdam, Netherlands4 aut
7001 a de Graaf, Nineu University of Amsterdam,Univ Amsterdam, Netherlands4 aut
7001 a Wellner, Ulrich F.u University Medical Center Schleswig-Holstein,Pancreas & Clin Surg, Germany4 aut
7001 a Johansen, Karinu Linköpings universitet,Linköping University,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten4 aut0 (Swepub:liu)karjo22
7001 a Andersson, Bodilu Lund University,Lunds universitet,Kirurgi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Lever-, pankreas- och gallvägskirurgi,Forskargrupper vid Lunds universitet,Artificiell intelligens och thoraxkirurgisk vetenskap (AICTS),LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Surgery (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Hepato-Pancreato-Biliary Surgery,Lund University Research Groups,Artificial Intelligence in CardioThoracic Sciences (AICTS),LUCC: Lund University Cancer Centre,Other Strong Research Environments,Skåne University Hospital,Lund Univ, Sweden; Lund Univ, Sweden; Skane Univ Hosp, Sweden4 aut0 (Swepub:lu)kir-ban
7001 a Beane, Joal D.u Ohio State University,Ohio State Univ, OH USA4 aut
7001 a Björnsson, Bergthoru Linköpings universitet,Linköping University,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Kirurgiska kliniken US4 aut0 (Swepub:liu)berbj34
7001 a Busch, Olivier R.u Baylor Scott and White Hospital,Univ Amsterdam, Netherlands4 aut
7001 a Gleeson, Elizabeth M.u University of North Carolina,Univ N Carolina, NC USA4 aut
7001 a van Santvoort, Hjalmar C.u University Medical Center Utrecht,Univ Med Ctr Utrecht, Netherlands4 aut
7001 a Tingstedt, Bobbyu Linköpings universitet,Linköping University,Institutionen för biomedicinska och kliniska vetenskaper,Medicinska fakulteten4 aut0 (Swepub:liu)n/a
7001 a Williamsson, Carolineu Linköpings universitet,Linköping University,Institutionen för biomedicinska och kliniska vetenskaper,Medicinska fakulteten4 aut0 (Swepub:liu)n/a
7001 a Keck, Tobiasu University Medical Center Schleswig-Holstein,Pancreas & Clin Surg, Germany4 aut
7001 a Besselink, Marc G.u Baylor Scott and White Hospital,Univ Amsterdam, Netherlands4 aut
7001 a Koerkamp, Bas Grootu Erasmus University Medical Center,Erasmus MC, Netherlands4 aut
7001 a Pitt, Henry A.u Rutgers Robert Wood Johnson Med Sch, NJ USA; 125 Little Albany St, NJ 08901 USA4 aut
7102 a Baylor Scott and White Hospitalb Baylor Scott & White Hlth, TX USA4 org
7102 a Global Audits on Pancreatic Surgery Group (GAPASURG)
7730 t Journal of the American College of Surgeonsd : LIPPINCOTT WILLIAMS & WILKINSg 238:4, s. 613-621q 238:4<613-621x 1879-1190x 1072-7515
8564 u http://dx.doi.org/10.1097/XCS.0000000000000971y FULLTEXT
8564 8u https://lup.lub.lu.se/record/b9de9bcd-e639-45a9-a5b1-19798046c884
8564 8u https://doi.org/10.1097/XCS.0000000000000971
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-205190

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