Sökning: WFRF:(Leslie T. A.) > Genome-wide associa...
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003 | SwePub | |
008 | 240913s2019 | |||||||||||000 ||eng| | |
009 | oai:lup.lub.lu.se:e3cc4683-efe4-47de-a091-291384242383 | |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1407183072 URI |
024 | 7 | a https://doi.org/10.1038/s41467-018-08053-52 DOI |
024 | 7 | a https://lup.lub.lu.se/record/e3cc4683-efe4-47de-a091-2913842423832 URI |
040 | a (SwePub)kid (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
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100 | 1 | a Ferreira, MAu QIMR Berghofer Medical Research Institute4 aut |
245 | 1 0 | a Genome-wide association and transcriptome studies identify target genes and risk loci for breast cancer |
264 | c 2019-04-15 | |
264 | 1 | b Springer Science and Business Media LLC,c 2019 |
520 | a Genome-wide association studies (GWAS) have identified more than 170 breast cancer susceptibility loci. Here we hypothesize that some risk-associated variants might act in non-breast tissues, specifically adipose tissue and immune cells from blood and spleen. Using expression quantitative trait loci (eQTL) reported in these tissues, we identify 26 previously unreported, likely target genes of overall breast cancer risk variants, and 17 for estrogen receptor (ER)-negative breast cancer, several with a known immune function. We determine the directional effect of gene expression on disease risk measured based on single and multiple eQTL. In addition, using a gene-based test of association that considers eQTL from multiple tissues, we identify seven (and four) regions with variants associated with overall (and ER-negative) breast cancer risk, which were not reported in previous GWAS. Further investigation of the function of the implicated genes in breast and immune cells may provide insights into the etiology of breast cancer. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
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700 | 1 | a Bogdanova, N4 aut |
700 | 1 | a Bojesen, SE4 aut |
700 | 1 | a Bolla, MK4 aut |
700 | 1 | a Borg, Åkeu Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Familjär bröstcancer,Forskargrupper vid Lunds universitet,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Familial Breast Cancer,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)onk-abo |
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700 | 1 | a Ellberg, Carolinau Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)med-elc |
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700 | 1 | a Olsson, Håkanu Lund University,Lunds universitet,Medicinsk onkologi,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumörmikromiljö,Institutionen för kliniska vetenskaper, Lund,Lunds Melanomstudiegrupp,Forskargrupper vid Lunds universitet,Medical oncology,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Tumor microenvironment,Department of Clinical Sciences, Lund,Lund Melanoma Study Group,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)onk-hol |
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710 | 2 | a QIMR Berghofer Medical Research Instituteb Bröstcancer-genetik4 org |
773 | 0 | t Nature communicationsd : Springer Science and Business Media LLCg 10:1, s. 1741-q 10:1<1741-x 2041-1723 |
856 | 4 | u https://www.nature.com/articles/s41467-018-08053-5.pdf |
856 | 4 | u http://dx.doi.org/10.1038/s41467-018-08053-5x freey FULLTEXT |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:140718307 |
856 | 4 8 | u https://doi.org/10.1038/s41467-018-08053-5 |
856 | 4 8 | u https://lup.lub.lu.se/record/e3cc4683-efe4-47de-a091-291384242383 |
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